Rapidly adapting receptor activity during oxidative stress induced airway hyperresponsiveness

Vashisht, Anmol; Chhabra, Sanjeev; Banerjee, B. D.; Ravindran, Krishnan

doi:10.1016/j.resp.2013.03.005

Cited by 1 publication

(1 citation statement)

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“… 41 Regulation and modulation of histamine levels by vitamin C appear to be biological phenomena because a similar relationship was reported in guinea pigs, who, like humans, cannot synthesize ascorbate. 43 In animals that synthesize vitamin C on demand, histaminosis is accompanied by a rise in circulating ascorbate. 44 Several investigations have shown a correlation between ascorbate depletion and histaminaemia.…”

Section: Discussionmentioning

confidence: 99%

Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study

et al. 2018

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ObjectiveOxidative stress appears to be a key factor in the pathogenesis of allergic diseases and a potential therapeutic target in allergy treatment. Allergic diseases are reportedly associated with reduced plasma levels of ascorbate, which is a key physiological antioxidant. Ascorbate prevents excessive inflammation without reducing the defensive capacity of the immune system.MethodsAn interim analysis of a multicenter, prospective, observational study was conducted to investigate the change in disease-specific and nonspecific symptoms (fatigue, sleep disorders, depression, and lack of mental concentration) during adjuvant treatment with intravenous vitamin C (Pascorbin®; Pascoe, Giessen, Germany) in 71 patients with allergy-related respiratory or cutaneous indications.ResultsBetween the start and end of treatment, the mean sum score of three disease-specific symptoms decreased significantly by 4.71 points and that of four nonspecific symptoms decreased significantly by 4.84 points. More than 50% of patients took no other allergy-related medication besides vitamin C.ConclusionsOur observations suggest that treatment with intravenous high-dose vitamin C reduces allergy-related symptoms. Our observations form a basis for planning a randomized controlled clinical trial to obtain more definitive evidence of the clinical relevance of our findings. We also obtained evidence of ascorbate deficiency in allergy-related diseases.Trial registration: Clinical Trials NCT02422901.

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Section: Discussionmentioning

confidence: 99%