Rapid visualizing and pathological grading of bladder tumor tissues by simple nanodiagnostics

Liu, Hongxing; Mei, Chaoming; Deng, Xuanru; Lin, Weiqiang; He, Lizhen; Chen, Tianfeng

doi:10.1016/j.biomaterials.2020.120434

Cited by 25 publications

(17 citation statements)

References 50 publications

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“…From our previous work, HSA, poly(lactic- co -glycolic acid) (PLGA), polyethylene glycol (PEG), and chitosan (CS) have excellent biocompatibility. − By comparing the stability of Mn 3 O 4 in aqueous solution between PLGA, CS, PEG, and HSA, HSA has the best effect on the stability of Mn 3 O 4 . Additionally, the dispersion of HSA-Mn 3 O 4 is greatly improved compared with unmodified Mn 3 O 4 .…”

Section: Results and Discussionmentioning

confidence: 99%

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke

et al. 2021

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Designing translational antioxidative agents that could scavenge free radicals produced during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main objective for ischemic stroke treatment. Herein, we explored and simply synthesized a biomimic and translational Mn3O4 nanoenzyme (HSA-Mn3O4) to constrain ischemic stroke reperfusion-induced nervous system injury. This nanosystem exhibits reduced levels of inflammation and prolonged circulation time and potent ROS scavenging activities. As expected, HSA-Mn3O4 effectively inhibits oxygen and glucose deprivation-mediated cell apoptosis and endoplasmic reticulum stress and demonstrates neuroprotective capacity against ischemic stroke and reperfusion injury of brain tissue. Furthermore, HSA-Mn3O4 effectively releases Mn ions and promotes the increase of superoxide dismutase 2 activity. Therefore, HSA-Mn3O4 inhibits brain tissue damage by restraining cell apoptosis and endoplasmic reticulum stress in vivo. Taken together, this study not only sheds light on design of biomimic and translational nanomedicine but also reveals the neuroprotective action mechanisms against ischemic stroke and reperfusion injury.

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Section: Results and Discussionmentioning

confidence: 99%

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke

et al. 2021

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“…Couramin-6-labelled TSIIA@SeNPs-APS for evaluation of cellular uptake and intracellular trafficking was synthesized according to the protocol of our previous study [ 54 ]. Briefly, coumarin-6 was added into the mixture of Na 2 SeO 3 , APS and TSIIA in the dark before the addition of Vc.…”

Section: Methodsmentioning

confidence: 99%

Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment

Rao

Lin

et al. 2022

J Nanobiotechnol

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Background As Traditional Chinese Medicine (TCM) drugs, Huangqi and Danshen are always applied in combination for spinal cord injury (SCI) treatment based on the compatibility theory of TCM. Astragalus Polysaccharidesis (APS) and Tanshinone IIA (TSIIA) are the main active ingredients of Huangqi and Danshen, and they both possess neuroprotective effects through antioxidant activities. However, low solubility and poor bioavailability have greatly limited their application. In recent years, selenium nanoparticles (SeNPs) have drawn enormous attention as potential delivery carrier for antioxidant drugs. Results In this study, TCM active ingredients-based SeNPs surface decorated with APS and loaded with TSIIA (TSIIA@SeNPs-APS) were successfully synthesized under the guidance of the compatibility theory of TCM. Such design improved the bioavailability of APS and TSIIA with the benefits of high stability, efficient delivery and highly therapeutic efficacy for SCI treatment illustrated by an improvement of the antioxidant protective effects of APS and TSIIA. The in vivo experiments indicated that TSIIA@SeNPs-APS displayed high efficiency of cellular uptake and long retention time in PC12 cells. Furthermore, TSIIA@SeNPs-APS had a satisfactory protective effect against oxidative stress-induced cytotoxicity in PC12 cells by inhibiting excessive reactive oxygen species (ROS) production, so as to alleviate mitochondrial dysfunction to reduce cell apoptosis and S phase cell cycle arrest, and finally promote cell survival. The in vivo experiments indicated that TSIIA@SeNPs-APS can protect spinal cord neurons of SCI rats by enhancing GSH-Px activity and decreasing MDA content, which was possibly via the metabolism of TSIIA@SeNPs-APS to SeCys2 and regulating antioxidant selenoproteins to resist oxidative stress-induced damage. Conclusions TSIIA@SeNPs-APS exhibited promising therapeutic effects in the anti-oxidation therapy of SCI, which paved the way for developing the synergistic effect of TCM active ingredients by nanotechnology to improve the efficacy as well as establishing novel treatments for oxidative stress-related diseases associated with Se metabolism and selenoproteins regulation.

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“…Advances in nanotechnology have facilitated the development of delivery systems to treat prostate-related disorders. Advantages of nanocarrier preparations include the combination of a variety of drugs, including biomacromolecule drugs; reduced degradation of unstable drugs for slow and controlled release; and increased residence time of relevant drugs to avoid frequent injections and meet the needs of prostatitis treatment ( Thakur and Agrawal, 2015 ; Liu et al, 2020 ; Liu et al, 2020 ; Wang et al, 2020 ; Lin et al, 2021 ; Liu et al, 2021 ). More importantly, the modular design and preparation characteristics of nanotechnology endow nanomaterials with intelligent characteristics ( van der Meel et al, 2019 ).…”

Section: Application Of Functionalized Nanomaterials In Prostatitismentioning

confidence: 99%

Therapeutic Applications of Functional Nanomaterials for Prostatitis

Liu

Chen

et al. 2021

Front. Pharmacol.

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Prostatitis is a common disease in adult males, with characteristics of a poor treatment response and easy recurrence, which seriously affects the patient’s quality of life. The prostate is located deep in the pelvic cavity, and thus a traditional infusion or other treatment methods are unable to easily act directly on the prostate, leading to poor therapeutic effects. Therefore, the development of new diagnostic and treatment strategies has become a research hotspot in the field of prostatitis treatment. In recent years, nanomaterials have been widely used in the diagnosis and treatment of various infectious diseases. Nanotechnology is a promising tool for 1) the accurate diagnosis of diseases; 2) improving the targeting of drug delivery systems; 3) intelligent, controlled drug release; and 4) multimode collaborative treatment, which is expected to be applied in the diagnosis and treatment of prostatitis. Nanotechnology is attracting attention in the diagnosis, prevention and treatment of prostatitis. However, as a new research area, systematic reviews on the application of nanomaterials in the diagnosis and treatment of prostatitis are still lacking. In this mini-review, we will highlight the treatment approaches for and challenges associated with prostatitis and describe the advantages of functional nanoparticles in improving treatment effectiveness and overcoming side effects.

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Rapid visualizing and pathological grading of bladder tumor tissues by simple nanodiagnostics

Cited by 25 publications

References 50 publications

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke

Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment

Therapeutic Applications of Functional Nanomaterials for Prostatitis

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