2010
DOI: 10.1016/j.bbagen.2010.06.001
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Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

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Cited by 104 publications
(93 citation statements)
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“…Mitochondrial accumulation of this category of targeted antioxidants has previously been shown in cells and in animal models using electron spin resonance spectroscopy (25) and an antibody against lipophilic TPP ϩ cation, the mitochondrialtargeting moiety (57). These methods are not established in our laboratory.…”
Section: Discussionmentioning
confidence: 95%
“…Mitochondrial accumulation of this category of targeted antioxidants has previously been shown in cells and in animal models using electron spin resonance spectroscopy (25) and an antibody against lipophilic TPP ϩ cation, the mitochondrialtargeting moiety (57). These methods are not established in our laboratory.…”
Section: Discussionmentioning
confidence: 95%
“…Pharmacologic inhibition of mitochondrial and NOX4 NADPH oxidase-derived ROS in aged Apoe -/ -mice attenuated the progression of atherosclerosis and preserved aortic compliance MitoTEMPO was shown to rapidly accumulate in the mitochondria of various tissues in mice after an IV injection (42). MitoTEMPO has been reported to decrease mitochondrial and vascular ROS levels, improve endothelial function, and protect against angiotensin II-induced hypertension in mice (15).…”
Section: Vendrov Et Almentioning
confidence: 99%
“…In the case of MitoQ, the role it plays in in vitro settings of mitochondrial oxidative stress has been shown to be beneficial in many conditions; moreover, its protective actions have also been observed in animal models of cardiometabolic diseases, including ischemia/reperfusion, diabetes, and sepsis, and also in patients (297). Notably, it has been demonstrated that MitoQ is uptaken rapidly from the blood into cells (246). To be of acceptable therapeutic relevance (among other necessary properties), mitochondria-targeted antioxidants must reach and accumulate inside the mitochondria within the cells of patients, ideally after oral administration (Fig.…”
Section: Skq1 Skqr1mentioning
confidence: 99%
“…Lipophilic cations take advantage of mitochondrial DJ m to facilitate their selective targeting and accumulation within the mitochondrial matrix (273). This process can be expressed by the Nernst equation, by which the uptake of these molecules increases *10-fold for every *60 mV of membrane potential, leading to significant uptake within mitochondria in vivo (246,271) (Figs. 8 and 9).…”
Section: B Targeted Mitochondrial Deliverymentioning
confidence: 99%