Rapid Transformation of Protein-Caged Nanomaterials into Microbubbles As Bimodal Imaging Agents

Lin, Ching-Yen; Chuang, Wen Kai; Huang, Zih Yun; Kang, Shih Tsung; Chang, Ching Yi; Chen, Ching Ta; Li, Jhih Liang; Li, Jimmy K.; Wang, Hsueh Hsiao; Kung, Fu Chen; Shen, Ji Lin; Chan, Wen Hsiung; Yeh, Chih Kuang; Yeh, Hung I.; Lai, Wen; Chang, Walter

doi:10.1021/nn300768d

Cited by 24 publications

(14 citation statements)

References 77 publications

(138 reference statements)

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“…The nanoantenna-assisted increase in the sensitivity of light to sound will also work in this scenario. Indeed, microscopic gas bubbles in liquids can be integrated with metal nanoparticles that are located in the shell of the bubble, thereby leading to the effect of a 'metal bubble' [130,131]. Such gas bubbles have already been employed as a bimodal biomedical imaging agent that provides contrast for both ultrasonic and optical imaging.…”

Section: Plasmonic Nanoantennas and Nanoparticlesmentioning

confidence: 99%

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Coupling light and sound: giant nonlinearities from oscillating bubbles and droplets

Maksymov

Greentree

2019

Nanophotonics

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Nonlinear optical processes are vital for fields including telecommunications, signal processing, data storage, spectroscopy, sensing, and imaging. As an independent research area, nonlinear optics began with the invention of the laser, because practical sources of intense light needed to generate optical nonlinearities were not previously available. However the high power requirements of many nonlinear optical systems limit their use, especially in portable or medical applications, and so there is a push to develop new materials and resonant structures capable of producing nonlinear optical phenomena with low-power light emitted by inexpensive and compact sources. Acoustic nonlinearities, especially giant acoustic nonlinear phenomena in gas bubbles and liquid droplets, are much stronger than their optical counterparts. Here, we suggest employing acoustic nonlinearities to generate new optical frequencies, thereby effectively reproducing nonlinear optical processes without the need for laser light. We critically survey the current literature dedicated to the interaction of light with nonlinear acoustic waves and highly-nonlinear oscillations of gas bubbles and liquid droplets. We show that the conversion of acoustic nonlinearities into optical signals is possible with low-cost incoherent light sources such as lightemitting diodes, which would usher new classes of low-power photonic devices that are more affordable for remote communities and developing nations, or where there are demanding requirements on size, weight and power. . 1: (a) Generation of new optical frequencies via a nonlinear optical interaction. High-power monochromatic laser light interacts with the nonlinear optical medium, e.g. a dielectric microresonator, to generate new optical frequencies [9]. (b, c) The nonlinear properties of sound can be used to generate optical nonlinearities without the need for high-power laser light. Low-power light couples to a sound wave via a deformable fluid, e.g. gas bubble or liquidmetal nanoparticle, exploiting strong nonlinear acoustic effects. This converts acoustic frequencies to the optical domain, effectively reproducing the result of the nonlinear optical interaction in (a). Images from www.freeimages.com and www.dreamstime.com. FIG

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Section: Plasmonic Nanoantennas and Nanoparticlesmentioning

confidence: 99%

“…Such gas bubbles have already been employed as a bimodal biomedical imaging agent that provides contrast for both ultrasonic and optical imaging. In particular, to be useful for optical imaging, the optical resonance of 'metal bubbles' falls within the visible-to-near-infrared spectral range [131].…”

Section: Plasmonic Nanoantennas and Nanoparticlesmentioning

confidence: 99%

Coupling light and sound: giant nonlinearities from oscillating bubbles and droplets

Maksymov

Greentree

2019

Nanophotonics

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“…Nanomaterials-including metals, metal oxide, semiconductors and polymers-have been extensively studied for applications in nanoscience and nanotechnology, due to their superior chemical and physical properties [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Among nanomaterials, the heterostructured nanomaterials have shown unique optical properties, including the increase of light absorption and the extension of absorption region [36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Light-Activated Heterostructured Nanomaterials for Antibacterial Applications

et al. 2020

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An outbreak of a bacterial contagion is a critical threat for human health worldwide. Recently, light-activated heterostructured nanomaterials (LAHNs) have shown potential as antibacterial agents, owing to their unique structural and optical properties. Many investigations have revealed that heterostructured nanomaterials are potential antibacterial agents under light irradiation. In this review, we summarize recent developments of light-activated antibacterial agents using heterostructured nanomaterials and specifically categorized those agents based on their various light harvesters. The detailed antibacterial mechanisms are also addressed. With the achievements of LAHNs as antibacterial agents, we further discuss the challenges and opportunities for their future clinical applications.

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“…11 Other PVA multimodal agents including poly(butyl cyanoacrylate) air-filled microbubbles have been used to encapsulate iron oxide particles for the combination of ultrasound and MRI. 14–19 Tartis et al combined positron emission tomography (PET) and US with the use of 18 F-labeled lipid particles encapsulating a perfluorobutane core. 20 We have previously described MB composed of poly(lactic acid) and have demonstrated that drugs such as doxorubicin can be incorporated into the polymer shell, with minimal compromise of the acoustic properties, indicating the potential of adding nanoparticle as a payload.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Loaded Polymeric Microbubbles as Contrast Agents for Multimodal Imaging

et al. 2015

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Ultrasound contrast agents are typically microbubbles (MB) with a gas core that is stabilized by a shell made of lipids, proteins, or polymers. The high impedance mismatch between the gas core and an aqueous environment produces strong contrast in ultrasound (US). Poly(lactic acid) (PLA) MB, previously developed in our laboratory, have been shown to be highly echogenic both in vitro and in vivo. Combining US with other imaging modalities such as fluorescence, magnetic resonance imaging (MRI), or computerized tomography (CT) could improve the accuracy of many US applications and provide more comprehensive diagnostic information. Furthermore, our MB have the capacity to house a drug in the PLA shell and create drug-loaded nanoparticles in situ when passing through an ultrasound beam. To create multimodal contrast agents, we hypothesized that the polymer shell of our PLA MB platform could accommodate additional payloads. In this study, we therefore modified our current MB by encapsulating nanoparticles including aqueous or organic quantum dots (QD), magnetic iron oxide nanoparticles (MNP), or gold nanoparticles (AuNP) to create bimodality platforms in a manner that minimally compromised the performance of each individual imaging technique.

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Rapid Transformation of Protein-Caged Nanomaterials into Microbubbles As Bimodal Imaging Agents

Cited by 24 publications

References 77 publications

Coupling light and sound: giant nonlinearities from oscillating bubbles and droplets

Coupling light and sound: giant nonlinearities from oscillating bubbles and droplets

Light-Activated Heterostructured Nanomaterials for Antibacterial Applications

Nanoparticle Loaded Polymeric Microbubbles as Contrast Agents for Multimodal Imaging

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