Rapid testing for respiratory syncytial virus in a paediatric emergency department: benefits for infection control and bed management

Diagnostic Accuracy of Rapid Antigen Detection Tests for Respiratory Syncytial Virus Infection: Systematic Review and Meta-analysis

“…Therefore, physicians can diagnose RSV ARI with confidence on the basis of a positive RSV RADT result. Timely and accurate diagnosis of RSV has the potential to improve patient care and decrease health care costs by permitting prompt hospital infection control measures (13)(14)(15)57) and by decreasing unnecessary antibiotic use (7-9) and unneeded ancillary investigations (e.g., chest radiography, blood cultures, and urine cultures) (10, 11).…”

“…Therefore, physicians can diagnose RSV ARI with confidence on the basis of a positive RSV RADT result. Timely and accurate diagnosis of RSV has the potential to improve patient care and decrease health care costs by permitting prompt hospital infection control measures (13)(14)(15)57) and by decreasing unnecessary antibiotic use (7-9) and unneeded ancillary investigations (e.g., chest radiography, blood cultures, and urine cultures) (10, 11).A key finding of our study is that RSV RADTs demonstrated a sensitivity of only 29% in adults. It should be noted that this pooled estimate of sensitivity is based on relatively limited data: 4 studies that evaluated RSV RADTs in 738 adults, including elderly and immunocompromised subjects (33,34,38,60).…”

“…Because concurrent serious bacterial infection with RSV is uncommon, especially in children (6), a timely diagnosis of RSV ARI should diminish unnecessary antibiotic use (7)(8)(9). It may also minimize ancillary testing (10), decrease hospital stay durations (11), and permit prompt implementation of cohort assignment for the purpose of limiting nosocomial transmission within hospitals and long-term-care facilities (13)(14)(15)(16)57). Laboratory testing of respiratory secretions is required for confirmation of RSV infection because its seasonality and nonspecific clinical manifestations may overlap those of other viral and bacterial causes of ARI (17,18).…”

Comparison of the GenMark Diagnostics eSensor Respiratory Viral Panel to Real-Time PCR for Detection of Respiratory Viruses in Children

“…Rapid and accurate laboratory detection of respiratory viruses plays an important role in clinical management, guiding the appropriate prescription of antivirals, reducing the need for additional diagnostic studies and hospital procedures, and limiting the use of unnecessary antibiotics (2,4,5,6,10,19,31,35). In addition, a virologic diagnosis is instrumental to efforts focused on prevention of health care-associated infections (3,9,23,24).PCR has demonstrated superior sensitivity for the detection of respiratory viruses over the more conventional laboratory methods of virus culture and rapid direct antigen detection tests (7,12,20,22,34). Both laboratory-developed and commercial molecular assays are now available, but the overall complexity of most of these tests has made implementation challenging for many clinical laboratories (18).…”

“…Rapid and accurate laboratory detection of respiratory viruses plays an important role in clinical management, guiding the appropriate prescription of antivirals, reducing the need for additional diagnostic studies and hospital procedures, and limiting the use of unnecessary antibiotics (2,4,5,6,10,19,31,35). In addition, a virologic diagnosis is instrumental to efforts focused on prevention of health care-associated infections (3,9,23,24).…”