Rapid testing for group B streptococcus during labour: a test accuracy study with evaluation of acceptability and cost-effectiveness

Abstract

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Cost‐effectiveness of rapid tests and other existing strategies for screening and management of early‐onset group B streptococcus during labour

“…11 Briefly, we approached 4873 pregnant women booked for delivery at one of two large UK participating obstetric departments (Birmingham Women's Hospital and King George Hospital, Essex), for consent to be recruited into the study. Women who agreed in principle to participate at 20-24 weeks of gestation were asked again for consent when they presented at labour or when they were admitted to an antenatal ward for induction of labour, after 24 weeks of gestation.…”

“…11 We obtained data on maternal colonisation rates from the results of the enriched culture tests performed on all women in the study.…”

“…Other strategies are analogous but are not presented here because of space constraints and are detailed elsewhere. 11 For any given screening strategy, the assumption is that all women presenting in labour are tested for GBS and those who tested positive are treated with antibiotics. In the model, we distinguished between spontaneous and caesarean delivery because the risk of GBS transmission from mother to baby is known to differ by type of delivery.…”

“…10 If affected, the case-fatality rate can be anywhere between 8 and 15%. 4,10,11 For those infants that survive the disease, the health and social care costs for the first 2 years of life have been estimated to be twice as high as those for unaffected infants. 9 The risk of transmitting GBS to newborns is reduced when intrapartum antibiotic prophylaxis (IAP) is administered to women sufficiently early before the baby is born.…”

Improving Rate of GBS Screening in Antenatal Patient to Improve Neonatal Outcome.

“…Signs and symptoms within a week or a few months of delivery, 2. Meningitis is the most common symptoms (7) .…”