Rapid synthesis of ‘yolk-shell’-like nanosystem for MR molecular and chemo-radio sensitization

Hou, Meirong; Zhu, Kai; Hu, Hai; Zheng, Shuting; Wu, Zede; Ren, Yunyan; Wu, Bin; Li, Qi; Wu, Dong; Xu, Yikai; Yan, Changqing; Zhao, Bingxia

doi:10.1016/j.jconrel.2022.04.033

Cited by 8 publications

(4 citation statements)

References 33 publications

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“…With the similar mechanism of AuFCSP MOFs, Hou et al . [ 71 ] fabricated a ‘yolk-shell’-like nanosystem (Bi 2 S 3 @mBi x Mn y O z ), integrating the radiant energy deposition ability of Bi 2 S 3 nanorods, the ferroptosis triggering ability of the Mn ions and the chemotherapeutic effect of doxorubicin (DOX). Results of in vitro and in vivo manifested that this combination strategy holds great promise to acquire the synergistic enhanced therapeutic effect.…”

Section: Tailoring Nanomaterials To Regulate Ferroptosis In Cancer Th...mentioning

confidence: 99%

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Liu

Zhao

Zhou

et al. 2023

Regenerative Biomaterials

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Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection and has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance, and low targeting ability, hindering their clinical applications. Nanotechnology provides new opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others and have been widely researched because of their unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application of those stimuli-responsive nanomaterials in ferroptosis. Here, we describe the physiological feature of ferroptosis and illustrate current challenges to induce ferroptosis for cancer therapy. Then, nanomaterials that induce ferroptosis are classified and elaborated according to external and internal stimuli. Finally, the future perspectives in the field are proposed. We hope this review facilitate paving the way for the design of intelligent nano ferroptosis inducers.

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Section: Tailoring Nanomaterials To Regulate Ferroptosis In Cancer Th...mentioning

confidence: 99%

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Liu

Zhao

Zhou

et al. 2023

Regenerative Biomaterials

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“…Along this way, Hou et al have reported the synthesis and the antitumor properties of PBmB-DOX NPs ( Hou et al, 2022 ). PBmB-DOX include a core of Bi 2 S 3 covered by PEGylated doxorubicin (DOX).…”

Section: Cross-talk Between Radiotherapy and Ferroptosis In Cancermentioning

confidence: 99%

Radiotherapy-induced ferroptosis for cancer treatment

Beretta

Zaffaroni

2023

Front. Mol. Biosci.

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Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical studies have demonstrated that the combination of ionizing radiation with small molecules or nano-systems is effective in combating cancer growth and overcoming drug or ionizing radiation resistance. Here, we briefly overview the mechanisms of ferroptosis and the cross-talk existing between the cellular pathways activated by ferroptosis and those induced by radiotherapy. Lastly, we discuss the recently reported combinational studies involving radiotherapy, small molecules as well as nano-systems and report the recent findings achieved in this field for the treatment of tumors.

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“…GNR@YS not only reduced the weight of the materials, but also provided a premise for the loading of functional small molecules. [29,30] Because of GNR@YS with a size range of 50 and 200 nm, they could be retained in the tumor without easy diffusion. Many cyanine dyes have the function of fluorescence tracing and good photothermal therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

Stable Hybrid Nanocapsules with Gold Nanorods and Cyanine Dyes for Near‐Infrared Photothermal Ablation of Subcutaneous Tumor

Shao

Hao

Guo

et al. 2023

Advanced Therapeutics

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Gold nanorods and cyanine dyes are promising to be widely used in photothermal therapy due to their adjustable absorption wavelength and excellent photothermal conversion efficiency. However, it is unclear how gold nanorods differ from cyanine dyes in therapeutic effects. Nanocapsules are synthesized from hybrid silica encapsulated gold nanorods (AuNRs@YSiO2, hereafter GNR@YS). Composite nanocapsules (hereafter GNR@YS‐CyN) are prepared from GNR@YS loaded with CyN to treat subcutaneous tumor. Cyanine dye (CyCl) with similar absorption to gold nanorods is also synthesized to match the existing commercial 808 nm laser. The results show that both materials have good therapeutic effect, but differ in healing scabs on skin tissue surface after tumor ablation. GNR@YS‐CyN are superior to CyCl in the treatment of subcutaneous tumor. This may be the size effect of GNR@YS‐CyN has permeability and retention enhancement effect at the tumor site. GNR@YS‐CyN have no obvious dye diffusion phenomenon, which reduces the damage to normal tissue.

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Rapid synthesis of ‘yolk-shell’-like nanosystem for MR molecular and chemo-radio sensitization

Cited by 8 publications

References 33 publications

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Radiotherapy-induced ferroptosis for cancer treatment

Stable Hybrid Nanocapsules with Gold Nanorods and Cyanine Dyes for Near‐Infrared Photothermal Ablation of Subcutaneous Tumor

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