Rapid stimulation, by vasopressin and adrenaline, of inorganic phosphate incorporation into phosphatidyl inositol in isolated hepatocytes

Kirk, Christopher J.; Verrinder, Terence R.; Hems, Douglas A.

doi:10.1016/0014-5793(77)81020-x

Cited by 75 publications

(30 citation statements)

References 20 publications

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“…AVP action on glycogenolysis is mediated via calcium-mobilizing V1a receptors in the liver, and phosphorylase kinase is activated by the Ca 2ϩ sensor calmodulin (273). Glucose homeostasis and V1a function have been analyzed in PHYSIOLOGY OF VASOPRESSIN V1a AND V1b RECEPTORS disease states, such as diabetes mellitus (DM) and impaired glucose tolerance.…”

Section: V1a Receptor and Glucose Homeostasismentioning

confidence: 99%

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Koshimizu

Nakamura

Egashira

et al. 2012

Physiological Reviews

324

297

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The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of physiological functions, including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior. These and other actions of AVP are mediated by at least three distinct receptor subtypes: V1a, V1b, and V2. Although the antidiuretic action of AVP and V2 receptor in renal distal tubules and collecting ducts is relatively well understood, recent years have seen an increasing understanding of the physiological roles of V1a and V1b receptors. The V1a receptor is originally found in the vascular smooth muscle and the V1b receptor in the anterior pituitary. Deletion of V1a or V1b receptor genes in mice revealed that the contributions of these receptors extend far beyond cardiovascular or hormone-secreting functions. Together with extensively developed pharmacological tools, genetically altered rodent models have advanced the understanding of a variety of AVP systems. Our report reviews the findings in this important field by covering a wide range of research, from the molecular physiology of V1a and V1b receptors to studies on whole animals, including gene knockout/knockdown studies.

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Section: V1a Receptor and Glucose Homeostasismentioning

confidence: 99%

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Koshimizu

Nakamura

Egashira

et al. 2012

Physiological Reviews

324

297

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“…Previous studies have demonstrated that 601 AVT and IT treatment, as well as osmotic challenges, enhance hepatic glycogenolytic 602 routes and free-glucose production processes in teleosts, including S. aurata (Janssens 603 and suggesting that the metabolic actions of AVT are controlled by this receptor in both 618 extreme salinities due to the higher energy requirement. Furthermore, hyper-and 619 hypoosmotic transfers also increased hepatic AVTR V1a2-type mRNA levels, the 620 effect of which could be associated with the incorporation of inorganic phosphate in 621 phosphatidyl inositol routes, acting as a substrate for phospholipase C, which is the 622 intracellular pathway for this type of AVT receptor (Kirk et al, 1977;1979). These 623 results suggest that gene activation of V1a2-type and/or V2-type receptors in the liver 624 and brain is related to the control of the energy supply due to the higher requirements 625 produced by the environmental salinity challenge.…”

Section: Statistics 339mentioning

confidence: 99%

Variations in the expression of vasotocin and isotocin receptor genes in the gilthead sea bream Sparus aurata during different osmotic challenges

Martos-Sitcha¹,

Fuentes²,

Mancera³

et al. 2014

General and Comparative Endocrinology

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The dynamic changes in mRNA expression levels for vasotocin (AVT) and isotocin (IT) receptor gene levels were assessed in a time-course response study in immature male specimens of the gilthead sea bream (Sparus aurata) submitted to hyper- (55‰ salinity) and hypo-osmotic (5‰ salinity) challenges. Two different cDNAs for the AVT receptor and one for the IT receptor (V1a2-type and V2-type AVTR, and ITR, respectively) were cloned by screening an S. aurata brain cDNA library. Genes for these receptors were expressed differentially and is nearly ubiquitously in 26 of the examined tissues. In the gills, both environmental salinity challenges up-regulated AVTR V1a2-type gene expression concomitantly with mRNA expression protein activity of Na(+), K(+)-ATPase gene expression and protein, whereas the AVTR V2-type and cystic fibrosis transmembrane conductance regulator (CFTR) mRNA levels were associated with mRNAs environmental salinity, indicating a possible connection between AVTRs and these transporters. In kidney, AVTR V1a2-type gene expression peaked rapidly and lasted only a short time (12-24h) in response to both osmotic challenges. In contrast, AVTR V2-type mRNA levels were enhanced in specimens exposed to hyperosmotic conditions, whereas they decreased under hypoosmotic environments, suggesting an antidiuretic role related to the vasoconstriction function. In the hypothalamus, only the expression of the AVTR V2-type gene was enhanced at 7 and 14 days under both experimental conditions. In the liver, both AVTRs had increased mRNA levels, with the upregulation of their AVTR V2-type gene increasing faster than the V1a2-type. The ITR gene was not sensitive to variations of external salinity in any of the analyzed tissues. Our results demonstrate the involvement of the vasotocinergic, but not the isotocinergic, pathway as well as the hypothalamic function, in the adjustments of both osmoregulatory and metabolic processes after osmotic challenges.

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“…24 -31 The V 1a receptor is associated with AVP's vasoconstrictor effect; however, it has also been found to mediate a multitude of other diverse physiologic effects (Table 2). 3,6,25,28,32,33 V 1a receptor stimulation shares the same intracellular activation pathway as angiotensin II receptor, consisting of phospholipase C activation, mobilization of intracellular Ca 2ϩ , and stimulation of protein kinase C. 34 Tahara et al also demonstrated that AVP, when added to growth arrested vascular smooth muscle cells induced hyperplasia and hypertrophy. The addition of a nonspecific vasopressin antagonist to these cell cultures inhibited AVP induced increase in intracellular free calcium and activation of mitogen activated protein kinase that prevented the AVP induced hyperplasia and hypertrophy.…”

Section: Vasopressin Receptorsmentioning

confidence: 93%

Vasopressin and Vasopressin Receptor Antagonists in Heart Failure

Oghlakian

Klapholz

2009

Cardiology in Review

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Antidiuretic hormone, also known as arginine vasopressin, is a hormone with a multitude of physiologic activities including the control of urinary free water excretion. Antidiuretic hormone also plays a role in vasoconstriction and has 3 receptors that have been identified. Vasopressin analogs and antagonists have been extensively studied in animal models as well as in humans. Because heart failure is associated with a state of water retention, several vasopressin antagonists have been evaluated for their potential aquaretic effect. Diuretics remain the mainstay of treatment in acute and chronic volume overload but are not shown to improve survival. In fact, they are associated with numerous side effects including hypotension, electrolyte abnormalities, worsening renal function, and activation of renin-angiotensin-aldosternone system. Tolvaptan, conivaptan, and lixivaptan are some of the vasopressin antagonists that have been studied in heart failure. The results were initially encouraging with alleviation of symptoms and effective aquaresis without worsening of hyponatremia or renal function, but yet failed to show any effect on mortality in heart failure. With an increasing number of more selective orally active vasopressin antagonists, further studies are underway to establish the role of "Vaptans" in the treatment of heart failure and other disease states with volume overload and hyponatremia.

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Rapid stimulation, by vasopressin and adrenaline, of inorganic phosphate incorporation into phosphatidyl inositol in isolated hepatocytes

Cited by 75 publications

References 20 publications

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Variations in the expression of vasotocin and isotocin receptor genes in the gilthead sea bream Sparus aurata during different osmotic challenges

Vasopressin and Vasopressin Receptor Antagonists in Heart Failure

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