Rapid-Steady-State-T<sub>1</sub>signal modeling during contrast agent extravasation: Toward tumor blood volume quantification without requiring the arterial input function

Sarraf, Michel; Perles-Barbacaru, Teodora-Adriana; Nissou, Marie-France; Sanden, Boudewijn van der; Berger, François; Lahrech, Hana

doi:10.1002/mrm.25218

Cited by 6 publications

(16 citation statements)

References 39 publications

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“…[21] In another respect, the whole blood accounts for 8% of the body weight. It was reported that blood volume fraction (BVf) in tumor is 3.4 AE 0.5%.…”

Section: Simulation Resultsmentioning

confidence: 99%

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

Liu

Xue

et al. 2015

Adv Eng Mater

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Magnetic drug targeting (MDT) with the attachment of therapeutics on magnetizable particles to position them to target locations for the enhancement of targeting efficiency (TE) would allow better treatment of not only cancer but other diseases. However, the TE is low usually. The prediction of TE is necessary but difficult in whether theoretical or experimental aspect. A pseudo-model strategy dependent on both the experiment and model was developed to this end. Two processes of blood circulation clearance and targeting magnetic migration were abstracted to depict the fate of in vivo injected magnetic particles. The pseudo-model is to calculate TE in terms of two variables, or the half lives representing the respective characteristic time for the two processes, which can be conveniently determined experimentally. Two magnetic particles of different mobility were prepared for the in vitro assessment of the model. The experimental results verified the reliability of the model. An optimal targeting time was proposed to guide the targeting process. The model also provides a clue that the TE cannot be high. The strategy can determine TE readily by broad choice of these parameters. ADVANCED ENGINEERING MATERIALS 2015, 17, No. 10 Y. Liu et al./A Pseudo-Model Strategy Combining Experiment and Model… ADVANCED ENGINEERING MATERIALS 2015, 17, No. 10

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“…[21] In another respect, the whole blood accounts for 8% of the body weight. It was reported that blood volume fraction (BVf) in tumor is 3.4 AE 0.5%.…”

Section: Simulation Resultsmentioning

confidence: 99%

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

Liu

Xue

et al. 2015

Adv Eng Mater

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“…1(d)]. Consequently, its BVf needs to be calculated using kinetic modeling 16 and results in a BVf of 0.4-0.11 in the tumor rim [ Fig. 1(e)].…”

Section: A Patientsmentioning

confidence: 99%

“…1(a) in Ref. 16] resulting from the short TI and TR, water exchange has less impact on BVf quantification than conventional dynamic or steady state techniques. 32 BVf overestimation can be kept within 10% by adjusting the injected CA dose in such a way that the CA concentration in blood reaches the required threshold without being unnecessarily high.…”

Section: B Water Exchangementioning

confidence: 99%

“…15 Alternatively, using typical clinical low molecular weight CAs, the tumor BVf can be derived from monitoring and modeling the signal increase during CA extravasation. 16 Since the RSST 1 -method leads to direct quantification of the BVf without requiring (i) conversion of the signal intensity change into CA concentration, (ii) determination of the AIF, (iii) complex signal analysis, (iv) additional T 1 mapping, 17,18 or (v) an additional conventional steady state technique, 19 it will be of interest in the clinical setting. However, clinically approved CAs have low r 1 , and CA dose is a limiting factor.…”

Section: Introductionmentioning

confidence: 99%

“…After having validated the RSST 1 -method in preclinical studies, 5,12,15,16 this study investigates whether it is feasible under clinical conditions. Most importantly, it has to be ensured that the threshold CA concentration in blood can be achieved without exceeding clinically tolerable doses.…”

Section: Introductionmentioning

confidence: 99%

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Technical Note: Clinical translation of the Rapid‐Steady‐State‐T₁ MRI method for direct cerebral blood volume quantification

et al. 2015

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Using approved doses of Gd-DOTA, the steady state RSST1-signal in brain tissue is reached during the first pass and corresponds to the BVf. The first-pass duration is sufficient to allow accurate BVf quantification. The RSST1-method is appropriate for serial clinical studies since it allows fast and straightforward BVf quantification without arterial input function determination. This quantitative MRI method is particularly useful to assess the efficacy of antiangiogenic agents.

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Quantitative MRI of Gd‐DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry

Tessier,

Ruze,

Varlet

et al. 2023

Magnetic Resonance Imaging

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BackgroundIn mice, intraperitoneal (ip) contrast agent (CA) administration is convenient for mapping microvascular parameters over a long‐time window. However, continuous quantitative MRI of CA accumulation in brain over hours is still missing.PurposeTo validate a quantitative time‐resolved MRI technique for mapping the CA kinetics in brain upon ip administration.Study TypeProspective, animal model.Specimen25 C57Bl/6JRj mice underwent MRI.Field Strength/Sequence7‐T, gradient echo sequence.AssessmentGd‐DOTA concentration was monitored by MRI (25 s/repetition) over 135 minutes with (N = 15) and without (N = 10) ip mannitol challenge (5 g/kg). After the final repetition, the brains were sampled to quantify gadolinium by mass spectrometry (MS). Upon manual brain segmentation, the average gadolinium concentration was compared with the MS quantification in transcardially perfused (N = 20) and unperfused (N = 5) mice. Precontrast T1‐maps were acquired in 8 of 25 mice.Statistical TestsOne‐tailed Spearman and Pearson correlation between gadolinium quantification by MRI and by MS, D'Agostino‐Pearson test for normal distribution, Bland–Altman analysis to evaluate the agreement between MRI and MS. Significance was set at P‐value <0.05.ResultsMRI showed that ip administered CA reached the blood compartment (>5 mM) within 10 minutes and accumulated continuously for 2 hours in cerebrospinal fluid (>1 mM) and in brain tissue. The MRI‐derived concentration maps showed interindividual differences in CA accumulation (from 0.47 to 0.81 mM at 2 hours) with a consistent distribution resembling the pathways of the glymphatic system. The average in‐vivo brain concentration 2 hours post‐CA administration correlated significantly (r = 0.8206) with the brain gadolinium quantification by MS for N = 21 paired observations available.Data ConclusionThe presented experimental and imaging protocol may be convenient for monitoring the spatiotemporal pattern of CA uptake and clearance in the mouse brain over 2 hours. The quantification of the CA from the MRI signal in brain is corroborated by MS.Evidence LevelN/ATechnical EfficacyStage 1

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Rapid-Steady-State-T₁signal modeling during contrast agent extravasation: Toward tumor blood volume quantification without requiring the arterial input function

Abstract: Straightforward tumor BVf quantification without AIF determination is demonstrated in presence of CA leakage. The method will facilitate angiogenesis assessment in longitudinal neuro-oncologic studies in particular when monitoring the response to antiangiogenic therapies.

Cited by 6 publications

References 39 publications

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

Technical Note: Clinical translation of the Rapid‐Steady‐State‐T₁ MRI method for direct cerebral blood volume quantification

Quantitative MRI of Gd‐DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry

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Rapid-Steady-State-T1signal modeling during contrast agent extravasation: Toward tumor blood volume quantification without requiring the arterial input function

Abstract: Straightforward tumor BVf quantification without AIF determination is demonstrated in presence of CA leakage. The method will facilitate angiogenesis assessment in longitudinal neuro-oncologic studies in particular when monitoring the response to antiangiogenic therapies.

Cited by 6 publications

References 39 publications

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

Technical Note: Clinical translation of the Rapid‐Steady‐State‐T1 MRI method for direct cerebral blood volume quantification

Quantitative MRI of Gd‐DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry

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Rapid-Steady-State-T₁signal modeling during contrast agent extravasation: Toward tumor blood volume quantification without requiring the arterial input function

Technical Note: Clinical translation of the Rapid‐Steady‐State‐T₁ MRI method for direct cerebral blood volume quantification