Rapid Specific and Label-Free Detection of Porcine Rotavirus Using Photonic Crystal Biosensors

Pineda, Maria F.; Chan, Leo Li‐Ying; Kuhlenschmidt, Theresa B.; Choi, Charles J.; Kuhlenschmidt, Mark S.; Cunningham, Brian T.

doi:10.1109/jsen.2009.2014427

Cited by 75 publications

(57 citation statements)

References 30 publications

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“…Accurate monitoring of contamination in sources of water-and food can prevent outbreak of disease [4]. Monitoring biological hazards has also been called for in the combat against bio-terrorism [5].…”

Section: Introductionmentioning

confidence: 99%

“…While platforms using electric or mechanical transducers exist [9][10][11][12], biochemical sensor platforms with optical readout seem particularly promising. Optical readout provides compatibility with the wet environment presented in a biological system [13,14], and can also be done without physically interconnecting the light source, transducer and light detector [4,15].…”

Section: Introductionmentioning

confidence: 99%

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Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application

Grepstad¹,

Kaspar²,

Solgaard³

et al. 2012

Opt. Express

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Abstract:A sensor designed to detect bio-molecules is presented. The sensor exploits a planar 2D photonic crystal (PC) membrane with sub-micron thickness and through holes, to induce high optical fields that allow detection of nano-particles smaller than the diffraction limit of an optical microscope. We report on our design and fabrication of a PC membrane with a nano-particle trapped inside. We have also designed and built an imaging system where an optical microscope and a CCD camera are used to take images of the PC membrane. Results show how the trapped nano-particle appears as a bright spot in the image. In a first experimental realization of the imaging system, single particles with a radius of 75 nm can be detected.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application

Grepstad¹,

Kaspar²,

Solgaard³

et al. 2012

Opt. Express

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show abstract

“…Accordingly, there are many applications such as display of primitive cells [2], cancer cell metastasis, biofilm and gene identification [4], biomolecular detection [5], DNA microarrays, and pharmaceutical drug screening [6][7][8]. These structures including cavities can be also used as label-free PC biosensors (kinetic imaging of cellsurface interactions) [9], immobilized protein targets [10].…”

Section: Introductionmentioning

confidence: 99%

Fotonik Kristal Levhalı Biyosensörler ve Uygulamaları

Erdiven¹,

Karadağ²

2017

Çukurova Üniversitesi Mühendislik-Mimarlık Fakültesi Dergisi

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ÖzBu çalışmada, fotonik kristalden tasarlanan biyosensör cihazı için rezonans frekansını değiştiren sıvı ortamın kırılma indisine ve titanyum dioksit (TiO 2 ) birim hücre içindeki küresel gümüş metal nanopartikülünün yarıçapına bağlı olarak değişen dolgu faktörü, duyarlılık, kalite faktörü ve lokal yoğunluk incelendi. Bu yapı tipik olarak protein-protein etkileşimi, ilkel hücrelerin görüntülenmesi, kanser hücresi metastazının var olup olmadığının, enzim ve Deoksiribonükleik asit (DNA) mikrodizilerin belirlenmesi için kullanılır. Önerilen hesaplamalar, rezonant dalga boyundaki kaymayı görmek için iki boyutlu TiO 2 fotonik kristal yapısında yaratılan boşluklarının kare örgüsünü ve hava boşluklarına yerleştirilen küçük bir küresel nanopartikülünü kapsamaktadır. Hesaplamalarda örgü sabiti olarak (a= 1 μm) kullanıldı. Analizler 1500-1550 nm dalga boyu aralığında yapıldı. Hesaplamalar, MIT Elektromanyetik Denklem Yayılımına dayalı zamanda sonlu farklar yöntemi yazılımı ile yapılmıştır.Anahtar Kelimeler: Fotonik kristal, Optik biyosensör, Kalite faktörü, Duyarlılık, Rezonans dalgaboyu Photonic Crystal Slab Biosensors and its Applications AbstractIn this study, filling factor, sensitivity, quality factor, and local density of states variation depending on resonance frequency changing refractive index of liquid medium and radius of spherical silver metal nanoparticle inside unit cell for titanium dioxide (TiO 2 ) photonic crystal slab biosensor device is investigated. This structure is typically used for protein-protein interaction, display of primitive cells, cancer cell metastasis, enzyme detection, Deoxyribonucleic acid (DNA) microarrays. Proposed calculations include a square lattice of air holes created in two-dimensional TiO 2 photonic crystal structure and a small spherical sphere nanoparticle into the air holes is put in order to see shift in resonant wavelength's. Lattice constant (a= 1 μm) was used in the calculations. Analyses have been performed in the wavelength range of 1500-1550 nm. The calculations were made by software MIT Electromagnetic Equation Propagation based finite-difference time-domain method.

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“…This can be done by developing efficient high sensitivity biosensors that are cheap and small, allowing them to be applied by physicians at point-of-care or even as a personal appliance in the comfort of our own homes. A technology proposed to realize these next generation biosensors, is label-free optical biosensing [3,4]. Label-free optical sensors can be made using micro-and nano-technology that generally provides devices that are cheap and small.…”

Section: Introductionmentioning

confidence: 99%

Detection of single nano-defects in photonic crystals between crossed polarizers

Grepstad¹,

Kaspar²,

Johansen³

et al. 2013

Opt. Express

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Abstract:We investigate, by simulations and experiments, the light scattering of small particles trapped in photonic crystal membranes supporting guided resonance modes. Our results show that, due to amplified Rayleigh small particle scattering, such membranes can be utilized to make a sensor that can detect single nano-particles. We have designed a biomolecule sensor that uses cross-polarized excitation and detection for increased sensitivity. Estimated using Rayleigh scattering theory and simulation results, the current fabricated sensor has a detection limit of 26 nm, corresponding to the size of a single virus. The sensor can potentially be made both cheap and compact, to facilitate use at point-of-care.

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Rapid Specific and Label-Free Detection of Porcine Rotavirus Using Photonic Crystal Biosensors

Cited by 75 publications

References 30 publications

Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application

Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application

Fotonik Kristal Levhalı Biyosensörler ve Uygulamaları

Detection of single nano-defects in photonic crystals between crossed polarizers

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