Rapid Sonochemical Synthesis of Luminescent and Paramagnetic Copper Nanoclusters for Bimodal Bioimaging

Wang, Chuanxi; Cheng, Hao; Sun, Yuanqing; Lin, Quan; Zhang, Chi

doi:10.1002/cnma.201500004

Cited by 51 publications

(34 citation statements)

References 57 publications

(30 reference statements)

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“…As same as our previous research, in this process, Na 2 MoO 4 ⋅2H 2 O could be reduced with GSH for its various functional groups, including carboxyl, amino and thiol groups . This reducing ability of GSH has been proved in previously reported nanomaterials ,. Moreover, GSH could worked as surface passivation agent and provided amino functional species for resultant MoS 2 QDs.…”

Section: Resultsmentioning

confidence: 99%

MoS₂‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al³⁺ and Fe³⁺ Simultaneously in Various Environment

Wang

Jiang

et al. 2018

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The development of a sensitive sensing platform with multiple ions recognition ability in various environment is of great importance. In this paper, cysteine‐functionalized MoS2 quantum dots (Cys‐MoS2 QDs) with stable fluorescence are synthesized by a simple amidation reaction. The resultant Cys‐MoS2 QDs show good dispersion in aqueous solution and blue emission (λem= 428 nm) with a quantum yield (∼5%). The Cys‐MoS2 QDs drastically have improved the surface chemical reactivities, which exhibit sensitive and selective “turn‐on” response to Al3+ and “turn‐off” response to Fe3+ simultaneously. Furthermore, we testify the feasibility of applying this fluorescent probe for real sample analysis through the detection of Al3+ and Fe3+ ions in lake water and tap water. Moreover, using HeLa cells as the model, the resultant nanosensor is demonstrated to monitor Al3+ and Fe3+ ions in living cells. Thus, resultant Cys‐MoS2 QDs could be used as a “turn‐on” and “turn‐off” dual‐model photoluminescence sensing platform for effective determination of Al3+ and Fe3+ simultaneously in various environment.

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Section: Resultsmentioning

confidence: 99%

MoS₂‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al³⁺ and Fe³⁺ Simultaneously in Various Environment

Wang

Jiang

et al. 2018

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“…Based on previous reports, glutathione (GSH) can be simultaneously worked as reducing agent and scaffold, due to their several functional groups such as thiol, carboxyl and amino. 43 Therefore, GSH is selected as the ligand, and the corresponding synthesis process of GSH-protected CuNCs is shown in Fig. 1.…”

Section: Resultsmentioning

confidence: 99%

Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb²⁺ in living cells

Wang

Cheng

Huang

et al. 2015

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A one-pot sonochemical reaction of Cu(NO3)2 with glutathione (GSH), the latter functioning as a reducing agent and a stabilizing agent, rapidly affords Cu nanoclusters (NCs). The as-prepared GSH-CuNCs possess a small size (∼2.2 ± 0.2 nm), red luminescence with quantum yield (5.3%), and water-dispersibility. Moreover, the fluorescence of the as-prepared GSH-CuNCs is responsive to pH so that the intensity of fluorescence increases rapidly with decreasing pH from 9 to 4. Besides, the GSH-CuNCs would be aggregated by Pb(2+) ions in aqueous solution which results in quenching of the fluorescence. Therefore, such GSH-CuNCs would be excellent candidates as fluorescent probes for the label-free detection of Pb(2+) with the limit of detection at 1.0 nM. Importantly, CAL-27 cells are used as models to achieve potential application as probes for monitoring Pb(2+) in living cells. Thus, these fluorescent CuNCs could work as an alternative to conventional fluorescent probes for biolabeling, sensing and other applications.

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“…Finally, Cu NCs have potential to be used for different imaging modalities in vivo upon appropriate modification. For instance, by using a one‐pot sonochemical route in which glutathione is used as both a reducing agent and a stabilizer, luminescent and magnetic Cu NCs can be generated for bimodal MRI/fluorescence imaging of cancer cells . Recently, ultrasmall chelator‐free radioactive 64 Cu‐incorporated Cu NCs can also be produced by using BSA, in the form of a conjugate with luteinizing hormone releasing hormone (LHRH), as a scaffold .…”

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

2020

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Theranostics refers to the incorporation of therapeutic and diagnostic functions into one material system. An important class of nanomaterials exploited for theranostics is metal nanoclusters (NCs). In contrast to gold and silver NCs, copper is an essential trace element for humans. It can be more easily removed from the body. This, along with the low cost of copper that offers potential large‐scale nanotechnology applications, means that copper NCs have attracted great interest in recent years. The latest advances in the design, synthesis, surface engineering, and applications of copper NCs in disease diagnosis, monitoring, and treatment are reviewed. Strategies to control and enhance the emission of copper NCs are considered. With this synopsis of the up‐to‐date development of copper NCs as theranostic agents, it is hoped that insights and directions for translating current advances from the laboratory to the clinic can be further advanced and accelerated.

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Rapid Sonochemical Synthesis of Luminescent and Paramagnetic Copper Nanoclusters for Bimodal Bioimaging

Cited by 51 publications

References 57 publications

MoS₂‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al³⁺ and Fe³⁺ Simultaneously in Various Environment

MoS₂‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al³⁺ and Fe³⁺ Simultaneously in Various Environment

Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb²⁺ in living cells

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

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Rapid Sonochemical Synthesis of Luminescent and Paramagnetic Copper Nanoclusters for Bimodal Bioimaging

Cited by 51 publications

References 57 publications

MoS2‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al3+ and Fe3+ Simultaneously in Various Environment

MoS2‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al3+ and Fe3+ Simultaneously in Various Environment

Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb2+ in living cells

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

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MoS₂‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al³⁺ and Fe³⁺ Simultaneously in Various Environment

MoS₂‐QD‐Based Dual‐Model Photoluminescence Sensing Platform for Effective Determination of Al³⁺ and Fe³⁺ Simultaneously in Various Environment

Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb²⁺ in living cells