Rapid, Solution-Based Characterization of Optimized SERS Nanoparticle Substrates

Laurence, Ted A.; Braun, Gary B.; Talley, Chad E.; Schwartzberg, Adam M.; Moskovits, Martin; Reich, Norbert O.; Huser, Thomas

doi:10.1021/ja806236k

Cited by 103 publications

(158 citation statements)

References 24 publications

(43 reference statements)

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“…Hollow Au or AuAg nanostructures provide enhanced SERS activity compared to that of solid Ag nanoparticles [178,179,187,188,191,213,214]. Schwartzberg et al [188] compared the SERS activity of 30 nm hollow Au nanoparticles with those of solid Ag nanoparticles and reported a 10-fold increase in the SERS signal consistency and by using these hollow gold nanostructures as pH sensors, they have shown about two-fold increase in resolution and 10-fold increase in precision over the Ag nanoparticlebased SERS probes.…”

Section: Applications Of Hollow Nanostructures and Advantages Vs Solmentioning

confidence: 99%

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

et al. 2016

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Metallic nanostructures have received great attention due to their ability to generate surface plasmon resonances, which are collective oscillations of conduction electrons of a material excited by an electromagnetic wave. Plasmonic metal nanostructures are able to localize and manipulate the light at the nanoscale and, therefore, are attractive building blocks for various emerging applications. In particular, hollow nanostructures are promising plasmonic materials as cavities are known to have better plasmonic properties than their solid counterparts thanks to the plasmon hybridization mechanism. The hybridization of the plasmons results in the enhancement of the plasmon fields along with more homogeneous distribution as well as the reduction of localized surface plasmon resonance (LSPR) quenching due to absorption. In this review, we summarize the efforts on the synthesis of hollow metal nanostructures with an emphasis on the galvanic replacement reaction. In the second part of this review, we discuss the advancements on the characterization of plasmonic properties of hollow nanostructures, covering the single nanoparticle experiments, nanoscale characterization via electron energy-loss spectroscopy and modeling and simulation studies. Examples of the applications, i.e. sensing, surface enhanced Raman spectroscopy, photothermal ablation therapy of cancer, drug delivery or catalysis among others, where hollow nanostructures perform better than their solid counterparts, are also evaluated.

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Section: Applications Of Hollow Nanostructures and Advantages Vs Solmentioning

confidence: 99%

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

et al. 2016

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“…5 We also reported a methodology for rapidly characterizing the SERS intensity distribution of individual hot spots by comparing the intensities from nanoparticles diffusing in solution. 2 More recently, methodological approaches have been reported for measuring entire spectra of flowing, individual nanoparticle clusters with high signal-to-noise. 6 Here, we develop a quantitative technique for analyzing SERS colloidal substrates based on determining the orientationally averaged intensity of those nanoparticle dimers or multimers for which the contribution of single dimer hot spots can be unequivocally determined.…”

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confidence: 99%

“…Aggregates or spherically symmetric nanoparticles only exhibit decays due to translational diffusion. 2 Hot spots formed by interparticle junctions exhibit a very strong polarization response that can be monitored at the single particle level. 12 A strong polarization response strongly suggests that a single hot spot dominates the observed signal; the only alternative interpretation is that multiple hot spots are aligned in a linear multimer by chance.…”

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confidence: 99%

Robust SERS Enhancement Factor Statistics Using Rotational Correlation Spectroscopy

et al. 2012

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We characterize the distribution of surface-enhanced Raman spectroscopy (SERS) enhancement factors observed in individual hot spots of single Ag "nanocapsules", encapsulated Ag nanoparticle dimers formed via controlled nanoparticle linking, polymer encapsulation, and small molecule infusion. The enhancement factors are calculated for over 1000 individual nanocapsules by comparing Raman scattering intensities of 4-mercaptobenzoic acid (MBA) measured from single SERS hot spots to intensities measured from high-concentration solutions of MBA. Correlation spectroscopy measurements of the rotational diffusion identify nanocapsules with signals dominated by single hot spots via their strong polarization response. Averaging over the entire surface of the nanocapsules, the distribution of enhancement factors is found to range from 10(6) to 10(8), with a mean of 6 × 10(6). Averaging only over nanoparticle junctions (where most SERS signals are expected) increases this average value to 10(8), with a range from 2 × 10(7) to 2 × 10(9). This significant statistical sampling shows that very high SERS enhancement factors can be obtained on a consistent basis using nanoparticle linking.

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“…SERS was first observed on the roughened surface of electrodes [8,9]. The Raman spectrum of pyridine was enhanced to almost more than million times in SERS on metal colloids [10].…”

Section: The Role Of Substrates and Mechanisms Of Enhancementmentioning

confidence: 99%

Pharmaceutical Characterization and Detection Using Surface-Enhanced Raman Scattering

Saleh¹

2017

Int Arch Clin Pharmacol

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Surface-enhanced Raman scattering (SERS) is a surface sensitive method that results in the enhancement of Raman scattering by molecules adsorbed on rough metal surfaces. The enhancement factor can be as much as 10 7 -10 15 , which allows the technique to be sensitive enough to detect single molecules. The rapid growth of pharmaceutical industries worldwide demands continuous development of efficient characterization techniques to detect the presence of the molecules at extremely low concentrations. SERS allows fast, sensitive detection of trace levels of key pharma molecules. This review highlights the requirements for SERS and its applications for pharmaceutical characterization.

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Rapid, Solution-Based Characterization of Optimized SERS Nanoparticle Substrates

Cited by 103 publications

References 24 publications

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

Robust SERS Enhancement Factor Statistics Using Rotational Correlation Spectroscopy

Pharmaceutical Characterization and Detection Using Surface-Enhanced Raman Scattering

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