Abstract:The multidrug resistance of numerous pathogenic microorganisms is a serious challenge that raises global healthcare concerns. Multi-target medications and combinatorial therapeutics are much more effective than single-target drugs due to their synergistic impact on the systematic activities of microorganisms. A synthetic lethal (SL) is a set of non-essential targets (i.e., reactions or genes) that prevent the proliferation of a microorganism when they are “knocked out” simultaneously. To facilitate the identif… Show more
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