Rapid Simultaneous Determination of Amphetamine, Methamphetamine, 3,4-Methylenedioxyamphetamine, 3,4-Methylenedioxymethamphetamine, and 3,4-Methylenedioxyethylamphetamine in Urine by Solid-Phase Extraction and GC-MS: A Method Optimized for High-Volume Laboratories*

Conjugates of p-hydroxymethamphetamine and 4-hydroxy-3-methoxymethamphetamine in blood obtained from methamphetamine and 3,4-methylenedioxymethamphetamine users: analysis by LC-MS-MS

“…To disclose the use of these drugs, analysis of MA, MDMA, and their metabolites in biological fl uids including urine and blood is indispensable for drug enforcement procedures [3][4][5][6][7]. Caldwell et al [8] reported that urinary excretion products of MA included the phydroxylation metabolite p-hydroxymethamphetamine (p-OHMA) and the N-demethylation product amphetamine (AP); p-OHMA was the dominant metabolite, representing almost 50% of all metabolites excreted.…”

Fast LC–MS/MS method for the determination of amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB and PMA in urine

“…As a confirmatory method, GC-MS has been the most widely used [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], but in this technique a time consuming derivatization step is required. LC-MS is an interesting alternative, offering highest sample throughput and less sample manipulation.…”

Pharmacokinetics of Ephedrine and Pseudoephedrine after Oral Administration of Kakkonto to Healthy Male Volunteers

“…Serum ephedrine and pseudoephedrine concentrations were measured using several methods with modifications [12][13][14][15][16][17][18][19] . Briefly, the d3 -form of each drug ／ （100 mL；1 ng／mL）was mixed with 1 mL serum in water, 3 mL 0.2 N HCl saturated with NaCl, and 5 mL n-hexane：ethyl acetate（9：1）for 5 min.…”