1984

DOI: 10.1111/j.1442-200x.1984.tb02187.x

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Rapid Serological Diagnosis of Mumops Virus Infection by an Enzyme-Linked Immunosorbent Assay of Mumps IgG and IgM Antibodies

Harumi Kuno-Sakai¹,

Mitsuhisa Isozaki²,

Mikio Kimuara³

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Cited by 3 publications

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Increased Serum Levels of Anti‐Mumps and Rubella Viruses Antibodies in Children with Kawasaki Disease

¹

1985

Pediatrics International

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Serum IgM and IgG antibodies against mumps virus and rubella virus were quantitated serially by enzyme‐linked immunosorbent assays in 15 children with Kawasaki disease. IgM antibody against mumps virus and IgG antibody against rubella virus were increased significantly in children with Kawasaki disease who had no previous history of mumps virus or rubella virus infection. Booster‐like effect in IgG antibody levels against mumps virus was observed in children with Kawasaki disease who had a previous history of exposure to mumps virus. Since none of the patients manifested clinical symptoms of mumps or rubella, the increased antibody levels against mumps and rubella may represent a part of the nonspecific increase in serum immunoglobulins in children with Kawasaki disease.

Increased Serum Levels of Anti‐Mumps and Rubella Viruses Antibodies in Children with Kawasaki Disease

¹

1985

Pediatrics International

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Serum IgM and IgG antibodies against mumps virus and rubella virus were quantitated serially by enzyme‐linked immunosorbent assays in 15 children with Kawasaki disease. IgM antibody against mumps virus and IgG antibody against rubella virus were increased significantly in children with Kawasaki disease who had no previous history of mumps virus or rubella virus infection. Booster‐like effect in IgG antibody levels against mumps virus was observed in children with Kawasaki disease who had a previous history of exposure to mumps virus. Since none of the patients manifested clinical symptoms of mumps or rubella, the increased antibody levels against mumps and rubella may represent a part of the nonspecific increase in serum immunoglobulins in children with Kawasaki disease.

Measles Mumps Rubella (MMR) Vaccine in Japan

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1988

Pediatrics International

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Two Doses of Measles Mumps Rubella (MMR) Vaccine

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1989

Pediatrics International

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A schedule of two doses of measles mumps rubella vaccine (MMR) at an interval of six weeks was tried in children aged between 12 and 48 months. One hundred percent sermonversion was attained in the measles HI (hemagglutinin inhibition) test, rubella HI test, and mumps ELISA test in both groups of children who received NIH (National Institute of Health, Japan) MMR lot B-30 and Kitasato MMR lot TV-1. The possibility of vaccine failure with one dose of measles vaccine is not negligible [ I ] , and the frequency of vaccine failure increases if three vaccines are combined in the form of MMR. Ow observations revealed that a few of the children who had received one dose of MMR remained seronegative with regard to measles H I antibody and rubella HI antibody, and that some of the children remained seronegative with regard to mumps ELISA antibody. A schedule of two doses of MMR was shown to be helpful in reinforcing immunity in children who did not respond satisfactorily to one dose of MMR. We concluded that two doses of MMR are preferable to control measles, mumps and rubella infections.(Acta Paediatr Jpn 1989; 3 l : 690 -697)

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