Rapid Serial Angiography in the Investigation of the Pharmacology of Brain Circulation in the Dog

Abstract

The values of cerebral circulation time were determined by means of rapid serial angiography in the chloralosed dog under control conditions, after administration of strychnine and after injection of ergotamine. These results were compared with those obtained by the simultaneous registration of the intracranial venous pressure. Confirming previous observations made by means of this latter technique, the angiographic results showed that strychnine reduces the cerebral circulation time by provoking an increase in cerebral blood flow, whereas ergotamine causes a cerebral vasoconstriction, thereby increasing intracranial circulation time. Moreover, a statistically significant inverse correlation exists between the values of the intracranial pressure and the cerebral circulation time. New evidence of the relationship between the extra- and the intracranial circulation was obtained by the angiographic observations; these latter data are discussed in relation with the problem of the lability of cerebral vasoconstrictor reactions.