Rapid screening of precursor and degradation products of chemical warfare agents in soil by solid-phase microextraction ion mobility spectrometry (SPME–IMS)

Rearden, Preshious; Harrington, Peter de B.

doi:10.1016/j.aca.2005.04.035

Cited by 121 publications

(58 citation statements)

References 30 publications

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“…The use of reference standards and their associated procedures under such conditions must be compatible with the demanding requirements of the security and military user [1,18,24,49]. The detection of chemical warfare agents, explosives and illicit drugs typically involves demanding and variable operating environments.…”

Section: (Taken From Eicemanmentioning

confidence: 99%

“…Lutidine ions produce a single, sharp IMS peak with a reduced mobility (K 0 ) value of 1.95 cm 2 V −1 s −1 (in air [15] and nitrogen [17]). The lutidine dimer peak can also be observed with K 0 of 1.43 cm 2 V −1 s −1 [6,18]. The mobility of lutidine has been examined using a range of ionisation techniques, including; 63 Ni, electrospray ionisation [19], photoionisation [17] and matrix-assisted laser desorption/ ionisation (MALDI) sources [20], all of which produced comparable IMS responses.…”

Section: Current Status Of Standardisation In Imsmentioning

confidence: 99%

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Chemical standards for ion mobility spectrometry: a review

Kaur-Atwal

O’Connor

Aksenov

et al. 2009

Int. J. Ion Mobil. Spec.

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Ion mobility spectrometry (IMS), using standalone instrumentation and hyphenated with mass spectrometry (IM-MS), has recently undergone significant expansion in the numbers of users and applications, particularly in sectors outside its established user base; predominantly military and security applications. Although several IMS reference standards have been proposed, there are no currently universally recognised reference standards for the calibration and evaluation of mobility spectrometers. This review describes current practices and the literature on chemical standards for validating IMS systems in positive and negative ion modes. The key qualities and requirements an 'ideal' reference standard must possess are defined, together with the instrumental and environmental factors such as temperature, electric field, humidity and drift gas composition that may need to be considered. Important challenges that have yet to be resolved are also identified and proposals for future development presented.

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Section: (Taken From Eicemanmentioning

confidence: 99%

Section: Current Status Of Standardisation In Imsmentioning

confidence: 99%

Chemical standards for ion mobility spectrometry: a review

Kaur-Atwal

O’Connor

Aksenov

et al. 2009

Int. J. Ion Mobil. Spec.

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“…In contrast, the ion mobility spectrometer (IMS) thechnique has a large potential for monitoring compounds, including explosives [7,8], illegal drugs [9,10], and chemical warfare gents [11,12] due to the advantages of being relatively inexpensive, less bulky, and portable. Recently IMS has been applied in the analysis of exhaled air [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

On-line measurement of propofol using membrane inlet ion mobility spectrometer

Zhou

Wang

Cang

et al. 2012

Talanta

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“…These studies include the analysis of hydrogen cyanide [46], VX [50,52], sarin [48 -50], soman [50], tabun [50], and mustard [51]. There have also been reports describing the detection of precursor chemicals and degradation products of CWAs using SPME [52][53][54][55].…”

mentioning

confidence: 99%

Hand-portable gas chromatograph-toroidal ion trap mass spectrometer (GC-TMS) for detection of hazardous compounds

Contreras

Murray

Tolley³

et al. 2008

J. Am. Soc. Mass Spectrom.

239

156

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A novel gas chromatograph-mass spectrometer (GC-MS) based on a miniature toroidal ion trap mass analyzer (TMS) and a low thermal mass GC is described. The TMS system has an effective mass/charge (m/z) range of 50-442 with mass resolution at full-width half-maximum (FWHM) of 0.55 at m/z 91 and 0.80 at m/z 222. A solid-phase microextraction (SPME) fiber mounted in a simple syringe-style holder is used for sample collection and introduction into a specially designed low thermal mass GC injection port. This portable GC-TMS system weighs <13 kg (28 lb), including batteries and helium carrier gas cartridge, and is totally self-contained within dimensions of 47 X 36 X 18 em (18.5 X 14 X 7 in.). System start-up takes about 3 min and sample analysis with library matching typically takes about 5 min, including time for column cool-down. Peak power consumption during sample analysis is about 80 W. Battery power and helium supply cartridges allow 50 and 100 consecutive analyses, respectively. Both can be easily replaced. An on-board library of target analytes is used to provide detection and identification of chemical compounds based on their characteristic retention times and mass spectra. The GC-TMS can detect 200 pg of methyl salicylate on-column. n-Butylbenzene and naphthalene can be detected at a concentration of 100 ppt in water from solid-phase microextraction (SPME) analysis of the headspace. The GC-TMS system has been designed to easily make measurements in a variety of complex and harsh environments. and toxic industrial chemicals (TICs), is a concern, the ability to rapidly detect and accurately identify such chemicals in harsh environments is of great utility. There is a need for field-portable, selective, and sensitive detectors for military and emergency first-responder operations and for on-site environmental contamination measurement, to mention only a couple of key applications. The development of fieldportable devices directed toward fast, on-site analysis is one of the most active research areas in analytical chemistry.Currently, several approaches for detection of CWAs and TICs are utilized by military personnel, first responders, and environmental scientists. They include dye solubility (detection paper), enzymatic reaction,

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Rapid screening of precursor and degradation products of chemical warfare agents in soil by solid-phase microextraction ion mobility spectrometry (SPME–IMS)

Cited by 121 publications

References 30 publications

Chemical standards for ion mobility spectrometry: a review

Chemical standards for ion mobility spectrometry: a review

On-line measurement of propofol using membrane inlet ion mobility spectrometer

Hand-portable gas chromatograph-toroidal ion trap mass spectrometer (GC-TMS) for detection of hazardous compounds

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