Rapid screening of 2-[]-fluoro-2-deoxy-D-glucose infusions for volatile organic compound contaminants by solid phase microextraction with gas chromatography—selective ion monitoring mass spectrometry (SPME-GC-SIMMS)

Kanu, Abu B.; Dixon, M; Yuan-Gang, ZU; Bailey, John E.; Gillies, James; Zweit, Jamal; Thomas, C. L. Paul

doi:10.1016/s0969-8043(02)00293-2

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…The loss of volatiles from sealed vials prior to analysis has been described recently in a study looking at the recovery of solvent residues from radio-pharmaceutical infusions. 8 In this instance the analyte losses of acetonitrile and ethanol were determined to be in the order of 75% to 98% over a period of 106 h.…”

Section: Rapid Screeningmentioning

confidence: 93%

Fast volatile organic compound recovery from soil standards for analysis by thermal desorption gas chromatography

Meniconi

Parris

Thomas³

2003

Analyst

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The development of high-throughput environmental screening assays are needed to meet high-specification data quality objectives (DQOs) that require large numbers of samples to be taken and analysed rapidly. The acquisition and stabilisation of the sample is a key technical and operational challenge in analytical sequences associated with the determination of volatile organic compound (VOC) contamination of soils. Further the development of miniaturised and embedded analytical systems for environmental conditioning monitoring requires the development of new sampling techniques. A proof-of-concept study is described that shows how pressurised gas, in this case carbon dioxide, may be used to recover reversibly-bound VOCs from soil into an adsorbent sampler, and then analysed by thermal desorption-gas chromatography. The effects of the volume of the pressurised gas, the gas flow rate and the mass of the soil sample on the recovery efficiency and breakthrough from the adsorbent trap were investigated in a preliminary characterisation study. Two distinct approaches were identified. The first involved ventilation of the voids within the soil matrix to displace the soil-gas headspace, a rapid screening approach. The second involved a more prolonged purge of the matrix to strip reversibly bound species into the gas phase and hence pass them into the adsorbent trap, a purge and trap approach. The shortest possible sample processing time required to yield analytically useful responses was 5 s with the use of the headspace approach. In this case n-octane, benzene and toluene were recovered from conditioned spiked soil samples at concentrations in the range 42 to 1690 mg kg(-1). The limit of detection for the system was estimated to be no greater than 1.2 mg kg(-1). Using the purge and trap variant enabled recovery efficiencies greater than 93% to be achieved with liquid spikes of n-octane onto soil samples. These preliminary studies showed that a system based on this approach would need to balance recovery efficiency, time and analyte breakthrough from the adsorbent trap.

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Section: Rapid Screeningmentioning

confidence: 93%

Fast volatile organic compound recovery from soil standards for analysis by thermal desorption gas chromatography

Meniconi

Parris

Thomas³

2003

Analyst

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“…The instability of aqueous standards of low solubility VOCs has been noted previously 26,28 as have the precautions taken to account for the volatility, stability and low solubility of such compounds. Standards were used immediately after preparation, and cross-contamination checks were run by taking blank runs between every measurement.…”

Section: Preparation Of Reagents and Standardsmentioning

confidence: 95%

The presumptive detection of benzene in water in the presence of phenol with an active membrane-UV photo-ionisation differential mobility spectrometer

Kanu

Thomas

2006

Analyst

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Studies with a new technique, active membrane-differential mobility spectrometry, with aqueous standards of benzene and phenol are described. The atmospheric pressure photo-ionisation chemistries of benzene and phenol in the presence of oxygen are similar in that benzene forms phenol radicals that subsequently react to yield diphenylether and 4-phenoxyphenol products. Further phenol sequesters charge from benzene ions leading to a significant loss of sensitivity. This is an important consideration in the development of screening techniques for the presence of benzene in environmental water samples. This challenge was addressed by including a pre-separation stage prior to photo-ionisation, and a 10 cm long polydimethylsiloxane active membrane inlet using nitrogen as a carrier gas was used to sample, concentrate and deliver low resolution separations to the 10.6 eV UV-ionisation region of a differential mobility spectrometer. Acetone was also proposed as a charge carrier for the UV photo-ionisation source; to promote phenol protonation and inhibit charge sequestration from benzene. The responses of the system to aqueous standards of benzene and phenol with and without acetone doping at 10.2 mg m(-3) were evaluated and four to five-fold increases in sensitivity were obtained with acetone doping. With a sampling time of 60 s and a total measurement cycle of 180 s it was possible to obtain quantitative responses to single standards over the concentration range 6 to 177 microg cm(-3) with linear correlations with R(2) values ranging from 0.97 to 0.99. The effects of the heating rate of the membrane and the dispersion field strength of the differential mobility spectrometer on sensitivity and the differentiation of benzene from phenol responses were optimised, leading to a configuration where a voltage heating programme of 4.75 V s(-1) was applied to a 124 microm stainless steel wire heating element within the active membrane, and a dispersion field strength of 22 kV cm(-1) was used to test a mixture of benzene (14 microg cm(-3)) and phenol (6 microg cm(-3)) in water. The presence of benzene was identified through the presence of a peak corresponding to a benzene response, V(C) = -9 V FWHM = 1 V, that followed the thermal desorption profile of benzene.

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“…bumpy WO3 hemitube nanostructure assisted by O 2 plasma surface modification with functionalization of graphene-based material 41 , electrospun SnO 2 nanofibers sensitized with reduced graphene oxide nanosheets 42 , benzoyl-DL-arginine-naphthylamide (BANA) test 43 , High Performance Liquid Chromatography (HPLC) 44 and Solid-Phase Micro Extraction-Gas Chromatography/Mass Spectrometry (SPME-GC/MS 45 ). On the other hand, the device employed in this study might allow, for instance, fast data collection to rapidly achieve an early diagnosis of viral hepatitis B, which is also characterized by elevated dimethile sulfide levels 46 or to establish a state of systemic and/or respiratory disease (such as pneumonia, pulmonary emphysema and bronchitis) that are characterized by elevated hydrogen sulfide, methyl mercaptan and dimethyl sulfide levels 47 .…”

Section: Body Weight (Kg)mentioning

confidence: 99%

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

Cerbo

Pezzuto

Canello³

et al. 2015

JoVE

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Halitosis is a common complaint involving social and communicational problems in humans and also affects the pet-owner relationship. In this randomized placebo-controlled crossover clinical evaluation, we assessed the effectiveness of a dedicated dietary supplement to improve chronic halitosis in 32 dogs of different breeds and ages. This protocol describes how to evalute the presence of oral volatile suphur compunds, e.g. methyl mercaptan, hydrogen sulfide and dimethyl sulfide, by means of a portable gas chromatograph device coupled with a syringe, which was used to collect the breath, and a dedicated software, which allows the operator to monitor each compound concentration during each measurement, in a relatively short time (8 min).

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Rapid screening of 2-[]-fluoro-2-deoxy-D-glucose infusions for volatile organic compound contaminants by solid phase microextraction with gas chromatography—selective ion monitoring mass spectrometry (SPME-GC-SIMMS)

Cited by 7 publications

References 5 publications

Fast volatile organic compound recovery from soil standards for analysis by thermal desorption gas chromatography

Fast volatile organic compound recovery from soil standards for analysis by thermal desorption gas chromatography

The presumptive detection of benzene in water in the presence of phenol with an active membrane-UV photo-ionisation differential mobility spectrometer

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

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