Rapid screening and determination of designer drugs in saliva by a nib‐assisted paper spray‐mass spectrometry and separation technique

Lee, Hsun; Jhang, Chih Sheng; Liu, Ju Tsung; Lin, Cheng Huang

doi:10.1002/jssc.201200480

Cited by 31 publications

(21 citation statements)

References 46 publications

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“…Although the methodology and specific aims of papers differ, they have a common theme in showing that PS-MS can detect and quantify therapeutic drugs [12], [1], [8], [18], [6], [11], [17], [4], [19], [15], [20], [21] and drugs of abuse [9], [5], [10] (including designer drugs [22], [23]). In many cases, these drugs and metabolites are detected at clinically or physiologically relevant concentrations with good quantitative performance directly from biofluid.…”

Section: A Xenobioticsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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Paper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations. _________________________________________________________________________________ AbstractPaper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations.

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Section: A Xenobioticsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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“…e mass spectrometer (Finnigan LCQ Classic LC/MS/MS) used in this study was the same instrument that was used in our previous study. 11,[20][21][22] e mass signal was recorded under the full scan mode (m/z 100-400). An Xcalibur data system was used for data collection, and the data were converted into an ASCII text le.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11] Furthermore, since the development of ambient ionization mass spectrometry, socalled paper spray-mass spectrometry (PS-MS) has opened new insights in the eld of mass spectrometric analysis and, since its debut on 2010, it has now become a quite popular and important method for use in mass spectrometry. 12) us far, PS-MS has been applied successfully in many areas of research, including food science, 13) the analysis of protein complexes, 14,15) bio uid samples, 16,17) the online chemical monitoring of cell cultures, 18) rapid discrimination of bacteria, 19) and drugs of abuse in whole blood or saliva, [20][21][22] and even in an ambient organic analysis. 23) Some novel alternate techniques based on PS-MS have also been reported, including a 3D-printed paper spray ionization cartridge/ continuous solvent supply and the rapid detection of cocaine residues by paper spray ionization coupled with ion mobility spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Development and Application of a Brush-Spray Derived from a Calligraphy-Brush-Style Synthetic Hair Pen for Use in ESI/MS

et al. 2017

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e development of a novel type of a sampling/ionization kit for use in electrospray ionization/mass spectrometry is reported. Using a small calligraphy-brush-style synthetic hair pen (nylon-brush), and analogous to paper-spray mass spectrometry, the analytes can be collected, elution/desorption and then ionized from the surface of the nylon-brush. e body of the kit was produced by means of a commercial 3D-printer, in which ABS (acrylonitrile butadiene styrene) was used as the starting material. Meanwhile, a small nylonbrush was embedded inside a 3D-printed plastic cell, in which a solvent was supplied to rinse the brush by means of capillary action. e size and weight of the kit were 1 g and 4 cm, respectively. e kit is disposable and it has various functions, including non-invasive sampling, sample-evaporation and ionization. As a result, when a type of pesticide was selected as the test sample (dimethoate; C 5 H 12 NO 3 PS 2 ), the limit of detection was determined to be 0.1 µg/mL. Collecting the pesticide from a leaf-surface (lettuce) was also successful. e process for fabricating the nylon-brush kit and the optimized experimental conditions are reported herein.

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“…In contrast to this, a nib-assisted device can be used to slowly and continually wet the paper, as shown in Figure 6 [20]. Herein, a piece of paper was cut into a triangular shape (5 mm in length and 3 mm wide at the base).…”

Section: Modificationsmentioning

confidence: 99%

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confidence: 99%

Paper Spray-MS for Bioanalysis

et al. 2014

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This Review provides a general understanding of paper spray-MS, including the methodology and theory associated with a number of different related applications. This method has become a direct sampling/ionization method for mass spectrometric analysis at ambient conditions and, as a result, it has greatly simplified and increased the speed of mass-spectrum analysis. It has now become an increasingly popular and important method for MS. The first part of this review discusses the fundamentals of paper spray. Some modifications are also reviewed, including nib-assisted paper spray, droplet monitoring, high-throughput paper spray, leaf spray, tissue spray and wooden tip spray. The second part focuses on recent applications, including the analysis of DBS, foodstuffs, drugs and oil. These studies show that paper spray-MS has great potential for use as a fast sampling ionization method, and for the direct analysis of biological and chemical samples at ambient conditions.

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Rapid screening and determination of designer drugs in saliva by a nib‐assisted paper spray‐mass spectrometry and separation technique

Cited by 31 publications

References 46 publications

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Development and Application of a Brush-Spray Derived from a Calligraphy-Brush-Style Synthetic Hair Pen for Use in ESI/MS

Paper Spray-MS for Bioanalysis

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