Rapid SARS-CoV-2 disinfection on distant surfaces with UV-C: The inactivation is affected by the type of material

Olagüe, Cristina; Mitxelena-Iribarren, Oihane; Sierra-García, J.Enrique; Rodriguez-Merino, Fernando; Maestro, Sheila; Pérez-Lorenzo, E.; Guillén-Grima, Francisco; González‐Aseguinolaza, Gloria; Arana, Sergio; Smerdou, Cristian

doi:10.1016/j.jpap.2022.100138

Cited by 4 publications

(1 citation statement)

References 27 publications

(35 reference statements)

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“…An enhanced understanding of the role of closed communal environments as a source of SARS‐CoV‐2 transmission has focused attention on the importance of environmental cleaning and disinfection as a means of reducing disease spread. Established techniques for whole‐room decontamination of public environments such as ultraviolet radiation has demonstrated sufficient efficacy toward the disinfection of SARS‐CoV‐2 ( 12 , 13 , 14 , 15 ); however, they are broadly limited to infrequent use in unoccupied and sealed environments due to their harmful radiation effects and long‐term material degradation upon repeated exposure ( 16 , 17 ). Consequently, novel methods of environmental decontamination to augment current SARS‐CoV‐2 infection control procedures are continuously being sought.…”

Section: Introductionmentioning

confidence: 99%

Viricidal Efficacy of a 405‐nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS‐CoV‐2

Sinclair

Ilieva

Morris

et al. 2023

Photochem & Photobiology

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The highly transmittable nature of SARS-CoV-2 has increased the necessity for novel strategies to safely decontaminate public areas. This study investigates the efficacy of a low irradiance 405-nm light environmental decontamination system for the inactivation of bacteriophage phi6 as a surrogate for SARS-CoV-2. Bacteriophage phi6 was exposed to increasing doses of low irradiance (~0.5 mW cm À2 ) 405nm light while suspended in SM buffer and artificial human saliva at low (~10 3-4 PFU mL À1 ) and high (~10 7-8 PFU mL À1 ) seeding densities, to determine system efficacy for SARS-CoV-2 inactivation and establish the influence of biologically relevant suspension media on viral susceptibility. Complete/near-complete (≥99.4%) inactivation was demonstrated in all cases, with significantly enhanced reductions observed in biologically relevant media (P < 0.05). Doses of 43.2 and 172.8 J cm À2 were required to achieve ~3 log 10 reductions at low density, and 97.2 and 259.2 J cm À2 achieved ~6 log 10 reductions at high density, in saliva and SM buffer, respectively: 2.6-4 times less dose was required when suspended in saliva compared to SM buffer. Comparative exposure to higher irradiance (~50 mW cm À2 ) 405-nm light indicated that, on a per unit dose basis, 0.5 mW cm À2 treatments were capable of achieving up to 5.8 greater log 10 reductions with up to 28-fold greater germicidal efficiency than that of 50 mW cm À2 treatments. These findings establish the efficacy of low irradiance 405-nm light systems for inactivation of a SARS-CoV-2 surrogate and demonstrate the significant enhancement in susceptibility when suspended in saliva, which is a major vector in COVID-19 transmission.

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Section: Introductionmentioning

confidence: 99%

Viricidal Efficacy of a 405‐nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS‐CoV‐2

Sinclair

Ilieva

Morris

et al. 2023

Photochem & Photobiology

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Investigation of Far-UVC (222 nm) disinfection of bioaerosols deposited on surfaces with different material properties

Guo,

Chen

2024

Journal of Hazardous Materials

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Analysis of a UV photocatalytic oxidation-based disinfection system for hydroxyl radicals, negative air ions generation and their impact on inactivation of pathogenic micro-organisms

Ahlawat,

Jangra,

Ish

et al. 2023

Review of Scientific Instruments

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This work presents a large-scale surface disinfection system, which has a unique lantern arrangement of ultraviolet-C (UV-C) light (254 nm) in conjunction with nanotechnology in a protective biosafety environment. Shadow regions are best dealt in this system by the generation of hydroxyl radicals (•OH) and negative air ions at sites where UV light cannot penetrate. More than 35 000 negative air ions/cm3 along with •OH were produced continuously in the disinfection chamber through the advanced photocatalytic oxidation process [UV-C + titanium dioxide (TiO2)]. The arrangement has been made to provide an optimized UV irradiation (∼2 mW/cm2) throughout the disinfection system. In order to distinguish between effects arising from (i) the action of UV dose alone and (ii) the action of UV dose along with •OH and negative air ions, E. coli and P. aeruginosa were chosen for bacterial testing and two interventions were made. The first intervention involved placing only UV lamps in the disinfection chamber to see the effect of only UV dose on bacterial inactivation efficiency. The second intervention involved placing the TiO2 nanoparticle coated aluminum plates along with UV lamps; this allows for the generation of negative air ions and •OH inside the disinfection chamber and enhanced bacterial inactivation efficiency. More than 95% bacterial inactivation efficiency has been reported in the case of UV-C + TiO2 compared to only 77% in UV only at the same time interval (90 s).

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Rapid SARS-CoV-2 disinfection on distant surfaces with UV-C: The inactivation is affected by the type of material

Cited by 4 publications

References 27 publications

Viricidal Efficacy of a 405‐nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS‐CoV‐2

Viricidal Efficacy of a 405‐nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS‐CoV‐2

Investigation of Far-UVC (222 nm) disinfection of bioaerosols deposited on surfaces with different material properties

Analysis of a UV photocatalytic oxidation-based disinfection system for hydroxyl radicals, negative air ions generation and their impact on inactivation of pathogenic micro-organisms

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