Rapid reversal of coagulopathy in patients on platelet aggregation inhibitors immediately prior to renal transplantation with recombinant factor VIIa?

Loertzer, Hagen; Soukup, Jens; Fornara, Paolo

doi:10.1111/j.1432-2277.2006.00302.x

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2010

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“…78 In another study, also involving healthy volunteers given aspirin plus clopidogrel, ex vivo rFVIIa reversed the inhibitory platelet effect of these agents. 3 In a letter to the editor, Loertzer et al 51 have described the prophylactic use of rFVIIa in 5 patients undergoing renal transplantation who were on aspirin or clopidogrel. These authors reported improvement in the coagulation parameters without thrombotic complications.…”

Section: Clopidogrelmentioning

confidence: 99%

Emergency reversal of anticoagulation and antiplatelet therapies in neurosurgical patients

Beshay

Morgan

Madden

et al. 2010

JNS

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Intracranial hemorrhage (ICH) is a common problem encountered by neurosurgeons. Patient outcomes are influenced by hematoma size, growth, location, and the timing of evacuation, when indicated. Patients may have abnormal coagulation due to pharmacological anticoagulation or coagulopathy due to underlying systemic disease or blood transfusions. Strategies to reestablish the integrity of the clotting cascade and platelet function assume a familiarity with these processes. As patients are increasingly treated with anticoagulants and antiplatelet agents, it is essential that the physicians who care for patients with ICH understand these pathways and recognize how they can be manipulated to restore hemostasis.

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Section: Clopidogrelmentioning

confidence: 99%