Rapid Resolution of Multiple Liver Abscesses in a Chronic Granulomatous Disease Patient with Granulocyte Transfusions

Abstract

Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immune deficiency of phagocyte function characterized by recurrent, life-threatening bacterial and fungal infections that lead to granuloma formation. Early diagnosis is possible by the awareness of the clinician about early infectious clues of the disease. Aggressive treatment of infectious complications is very important in CGD patients and subsequently antimicrobial (antibiotic and antifungal) and immunomodulatory (interferon-gamma) prophylaxis until hematopoietic stem cell transplantation. Despite improved mortality, morbidities due to complications associated with CGD remain significant. One of these is a hepatic abscess in CGD patients which is seen in more than one-quarter of patients and also very refractory and frequently requires multiple surgeries with frequent morbidities. Therefore, the most optimal and beneficial treatments are still being investigated in the world. We present a 3 y old CGD patient with multiple liver abscesses due to S.aureus and Aspergillus spp who treated by several percutaneous liver-directed interventional radiological treatment along with granulocyte transfusions.