Rapid reduction of hepatitis C virus‐Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients

Kondo, Yasuteru; Ueno, Yoshiyuki; Wakui, Yuta; Ninomiya, Masashi; Kakazu, Eiji; Inoue, Jun; Kobayashi, Koju; Obara, Noriyuki; Shimosegawa, Tooru

doi:10.1111/j.1872-034x.2011.00878.x

Cited by 9 publications

(8 citation statements)

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“…Kondo etc observed 12 CHC patients treated with DFPP/PEG-IFN/RBV therapy. The rapid reduction of HCV-Core antigens and changes in the distribution of lymphoid cells could contribute to the favorable immunological response during the DFPP/Peg-IFN/RBV therapy [35], [36]. However, the effect of DFPP in MHD patients with CHC has not been reported.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Immunoloregulation of Double Filtration Plasmapheresis in Maintenance Hemodialysis Patients with Chronic Hepatitis C

et al. 2013

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Although a large number of drugs have been used to treat chronic hepatitis C (CHC), there still remains a great challenge to treat maintenance hemodialysis (MHD) patients with chronic hepatitis C. To clarify the immunnoloregulation of double filtration plasmapheresis (DFPP) in MHD patients with CHC, DFPP was performed in 20 MHD patients with CHC (HCV-antibody positive, serum HCV RNA >500 IU/ml more than 6 months and HCV genotype 1b). The clinical data was collected and peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry at the time of hour 0, hour 3, day 3, day 7 and day 28 after the DFPP, respectively. Serum HCV particles could be removed partially by the DFPP. The titer of serum HCV RNA could remain in a lower level even 28 days after the treatment. Compared to MHD patients without HCV infection, the frequencies of innate immune cells were similar in MHD patients with CHC, while Th1/Th2 was elevated and the frequencies of regulatory T (Treg) cells were higher in those MHD patients with CHC. The frequencies of monocytes and natural killer (NK) cells remained after the DFPP in MHD patients with CHC. There were no significant changes of Th1, Th2 and Th1/Th2 in PBMC after DFPP. DFPP could reduce the frequencies of Th17 cells and Treg cells in PBMC from 7 days after DFPP in MHD patients with CHC. DFPP could partially remove the serum HCV particles mechanically. The titer of HCV RNA could remain in a lower level at least for 28 days probably due to the redistribution of the immunocytes in circulation.

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Section: Discussionmentioning

confidence: 99%

A Study of the Immunoloregulation of Double Filtration Plasmapheresis in Maintenance Hemodialysis Patients with Chronic Hepatitis C

et al. 2013

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“…In this study, we analyzed sequentially various kinds of immune cells including activated CD3 + T cells, CD4 + T cells, CD8 + T cells, CD19 + B cells, activated B cells, Th1 cells, Th2 cells, Th17 cells and CD4 + CD25 + interleukin (IL)‐7R − Treg. Moreover, the detection of strand‐specific HCV RNA was carried out because we previously reported that lymphotropic HCV could affect T‐cell commitment and immunoglobulin hypermutation …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the detection of strand-specific HCV RNA was carried out because we previously reported that lymphotropic HCV could affect T-cell commitment and immunoglobulin hypermutation. 3,4,6,7,13,14…”

Section: Introductionmentioning

confidence: 99%

Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum‐like lesions

Kondo

Iwata

Haga

et al. 2013

Hepatology Research

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Hepatitis C virus (HCV) can affect immune cells and induce various kinds of immune-related diseases including pyoderma gangrenosum. We experienced a difficult-to-treat case of pyoderma gangrenosum-like lesions in a patient with HCV infection. The patient was treated with pegylated interferon (PEG IFN)-α-2b and ribavirin (RBV) therapy and achieved a sustained virological response. Before the eradication of HCV, the frequency of T-helper 17 cells was remarkably high in comparison to chronic hepatitis C patients without extrahepatic immune-related diseases. Moreover, we could detect negative and positive strand-specific HCV RNA in the CD19(+) B lymphocytes and CD4(+) T lymphocytes. However, after the eradication of HCV, the immunological status became normal and the pyoderma gangrenosum-like lesions became stable without immunosuppressive therapy. Here, we report a sequential immunological analysis during PEG IFN/RBV therapy and the beneficial effect of HCV eradication in difficult-to-treat pyoderma gangrenosum-like lesions.

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“…Therefore, we speculated that the reduction of extracellular HCV‐related antigens might be able to improve the HCV‐specific immune responses. In our previous reports, we determined that the HCV‐Core antigen binding on CD3+ T‐cells could suppress the STAT‐1/T‐bet signaling (2,3). However, although the size of HCV‐Core antigens is smaller than the target size of filtration, HCV‐Core and other HCV‐related antigens binding with core antibody and unknown proteins can be removed by DFPP.…”

mentioning

confidence: 98%

“…More recently, we reported that DFPP could efficiently induce the Th1 immune response that might be favorable to reduce the HCV titer. These effects could be induced more efficiently in early virological response (EVR) patients than in late virological response (LVR) and no virological response (NVR) patients (2). Therefore, we speculated that the reduction of extracellular HCV‐related antigens might be able to improve the HCV‐specific immune responses.…”

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confidence: 99%

Double Filtration Plasmapheresis Could Induce a Favorable Immune Response for Chronic Hepatitis C Therapy

2012

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Rapid reduction of hepatitis C virus‐Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients

Abstract: The rapid reduction of HCV-Core antigens and changes in the distribution of lymphoid cells could contribute to the favorable immunological response during DFPP/Peg-IFN/RBV therapy.

Cited by 9 publications

References 38 publications

A Study of the Immunoloregulation of Double Filtration Plasmapheresis in Maintenance Hemodialysis Patients with Chronic Hepatitis C

A Study of the Immunoloregulation of Double Filtration Plasmapheresis in Maintenance Hemodialysis Patients with Chronic Hepatitis C

Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum‐like lesions

Double Filtration Plasmapheresis Could Induce a Favorable Immune Response for Chronic Hepatitis C Therapy

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