Rapid Redistribution of Serum Thyroxine During Ether Anesthesia

Fore, William W.; Köhler, Peter; Wynn, James

doi:10.1210/jcem-26-8-821

Cited by 17 publications

(10 citation statements)

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“…This was reflected by the rapid exponentially linear decline in the urinary 'I/I ratio slope values generated during this phase. The half-life of this slope approximated [8][9][10] Projection of the initial linear slope is depicted as an interrupted line in Fig. 1 It should be noted that the rate of rise in ratio values during the release phase in the typical thyrotoxic subject was greater than that found in the euthyroid patient and, in turn, more than that observed in the hypothyroid patient.…”

Section: Resultsmentioning

confidence: 99%

“…Studies of thyroid function performed in laboratory animals have revealed that this reserve capacity is frequently tested by a wide variety of both physiological and pharmacological stimuli (2)(3)(4)(5)(6)(7)(8)(9). In contrast, similar studies performed in man have not revealed such lability in thyroid function (10)(11)(12)(13)(14)(15). Indeed, the phylogenetic development in man of a large extrathyroidal pool of thyroxine bound to thyroxine-binding proteins would appear to Received for publication 22 April 1970 and in revised form 18 June 1970. act to assure constancy of this supply of thyroxine to peripheral target tissues by buffering variations in hormone secretion.…”

Section: Introductionmentioning

confidence: 99%

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A new method for the measurement of thyroidal iodine release in man

Nicoloff¹

1970

J. Clin. Invest.

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ABSTRA CT A new method is described for the detection of variations in the release rate of all iodinated products by the thyroid gland in man. 'I was employed to endogenously label the thyroid gland, and a parenterally administered '81I thyroxine dose was used to generate a 181I reference source. Thyroidal iodine release activity was quantitatively assessed by the measurement of variations in 'I/I ratio values obtained in timed urine samples. Diurnal variation in thyroid release patterns was observed in euthyroid subjects which was promptly suppressed by exogenous triiodothyronine administration and was simulated by the intramuscular injection of 0.25-0.50 U of bovine thyrotropin. The zenith value occurred at 4:00 a.m. ±3.4 hr (SD) and the nadir at 5:00 p.m. ±3.6 hr. The absence of a diurnal pattern in patients with thyrotoxicosis and in secondary hypothyroidism indicated that this diurnal fluctuation was under thyrotropin (TSH) regulation. This new method also promises to be a useful tool for the study of the intrathyroidal recycling of iodide from the iodotyrosine pool and the detection of factors which may acutely alter thyroid function.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A new method for the measurement of thyroidal iodine release in man

Nicoloff¹

1970

J. Clin. Invest.

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“…This would be analogous to the demonstrated effect on thyroxine levels by ether and halothane anesthesia. Fore (8) proved that the elevation induced in TT 4 by ether was independent of the thyroid gland, and Oyama et al (9) presented evidence that the additional thyroxine came from the liver. The peak elevation after ether anesthesia was seen at 40 minutes and basal levels returned at two hours.…”

Section: Discussionmentioning

confidence: 99%

Observations on the Effect of Heparin on Free and Total Thyroxine

Saeed-uz-Zafar

Miller

Breneman

et al. 1971

The Journal of Clinical Endocrinology & Metabolism

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“…The only agent previously shown to displace labeled T4 from the liver (40) with a concomitant rise in serum radioactivity (40,41) is diethyl ether; a similar redistribution of T4 may be caused by halothane (42) and isoflurane (43). The published data concerning the effects of ether anesthesia on radioactivity in serum, liver, and thigh in subjects who had received [131I]T4 60 h earlier (40) can be interpreted as showing some discharge from the thigh as well as the liver,5 in contrast to tyropanoate which does not discharge T4 from the thigh.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Hepatic Binding of Thyroxine by Cholecystographic Agents

Felicetta¹,

Green²,

Nelp³

1980

J. Clin. Invest.

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A B S T R A C T Subsequent to studies indicating that cholecystographic agents and sulfobromophthalein (BSP) inhibit uptake of thyroxine (T4) by rat liver slices, the effect of such compounds on hepatic storage of T, in man has been examined. After intravenous administration of [1'251]T4 to five normal subjects, hepatic radioactivity, estimated by external gamma counting, rose to a peak in -4 h and then declined in parallel with serum radioactivity. When a 6-g dose of the cholecystographic agent, tyropanoate (Bilopaque), was administered orally 3 d later, estimated hepatic extravasctilar radioactivity fell 50-60% within 4 h and then rose toward the pretyropanoate value. Concomitant with the fall in hepatic radioactivity, serum radioactivity rose 57-70%, as did stable T4 levels in serum, suggesting that hormone discharged from the liver entered the serum. Both uptake ofT4 and discharge by tyropanoate were much less in two patients with liver disease.Ipodate (Oragrafin), 12 g orally in two subjects, caused much smaller changes in hepatic and serum radioactivity. However, ipodate also caused a doubling of the percenit free T4 in the serum as judged by equilibrium dlialvsis, and the ratio of hepatic radioactivity to free I' I]T4 in serum declined markedly after ipodate, similar to the fall in hepatic:serum 1251 ratios after tyropanoate. BSP, 20 mg/kg i.v. in three subjects, caused a smaller change; the decline in hepatic T4 content averaged 19%.We conclude that these organic anions, tyropanoate, ipodate, and BSP, all can displace T4 from the liver.The restults imply a link between T4 transport and organic anion transport, and indicate 'a mechanism for altering hepatic T4 content in man that could be the site of physiologic regulation or of disease. A method is described whereby analysis of the change in hepatic and plasma radioactivity after tyropanoate could be employed to estimate hepatic T4 content in diverse clinical circumstances.

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Rapid Redistribution of Serum Thyroxine During Ether Anesthesia

Cited by 17 publications

References 0 publications

A new method for the measurement of thyroidal iodine release in man

A new method for the measurement of thyroidal iodine release in man

Observations on the Effect of Heparin on Free and Total Thyroxine

Inhibition of Hepatic Binding of Thyroxine by Cholecystographic Agents

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