Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects

Abstract

Our findings suggest that the mononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells. Rapid recruitment of CD14(+) monocytes to the challenged site indicates that these proinflammatory mononuclear phagocytes have a central role in orchestrating local allergic inflammation.

Monocytes accumulate in the airways of children with fatal asthma

“…| 1633 respiratory mucosa. This observation was consistent with our previous study, 10 and further substantiated the finding that monocytes are recruited in large numbers to the challenged nasal mucosa of AR patients, whereas the density of macrophages remains unchanged. 17 Furthermore, we recently reported that blood monocytes constitutively migrate into the intestinal mucosa where they develop into mature macrophages, with a progressive loss of S100A8/A9 expression as part of the differentiation process.…”

“…This model of in vivo experimentally induced human AR induces typical AR symptoms, and the recruitment of eosinophils, as demonstrated in previous studies from our group 10,15. This model of in vivo experimentally induced human AR induces typical AR symptoms, and the recruitment of eosinophils, as demonstrated in previous studies from our group 10,15.…”

“…10,15,21 Recruitment of CD1c+ cDCs and pDCs has also been found in the allergic inflammation of asthmatics, 5,6,22 but whether monocytes contribute to the inflammatory reaction in allergic asthma has not been examined. However, tissue DCs and macrophages were both strongly outnumbered by a robust and rapid influx of proinflammatory monocytes.…”

“…10 Global transcriptome analysis of APCs (including monocytes) isolated from the challenged mucosa showed increased expression of genes for several Th2-associated chemokines concomitant with recruitment of T cells and eosinophils. 10 Global transcriptome analysis of APCs (including monocytes) isolated from the challenged mucosa showed increased expression of genes for several Th2-associated chemokines concomitant with recruitment of T cells and eosinophils.…”

Human dendritic cell subsets: an update

“…184,185). In humans, inflammatory myeloid cells have been reported in several settings including eczema, 186 psoriasis, 187,188 skin sensitization, 189 allergic rhinitis, 190 coeliac disease, 191 inflammatory bowel disease, 192,193 synovitis and peritonitis. 24,194 Kinetics, surface markers, gene expression and even direct labelling suggest that monocytederived cells dominate these populations.…”