Rapid quantitative analysis of morphine in blood by flash-heater methylation and gas chromatography with a nitrogen-specific detector

Kim, C.

doi:10.1007/bf02268779

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Although modern cell culture techniques such as those involving root and hairy root cultures afford relatively high alkaloid levels in appropriate production organisms, a higher detector sensitivity is always desirable. However, steady development work on NPD has yielded an efficient device for many analytical applicatons involving alkaloids (Vitzhum et al, 1974;Kinsun and Moulin, 1977;Severson et al, 1981;Turner et a[., 1981;Kim 1986). In the present investigation, application of a GC-NPD detector/PTV injector assembly has been compared with that of more conventional instrumentation in the analysis of some tropane alkaloids.…”

Section: Introductionmentioning

confidence: 99%

Nitrogen‐phosphorus detector potential in tropane alkaloid gas chromatography

Martinsen

Hiltunen

Huhtikangas

1992

Phytochemical Analysis

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A gas chromatographic (GC) nitrogen‐phosphorus detector (NPD) is compared with a flame ionization detector (FID) for the quantitation of some important tropane alkaloids present in plant material. Though slightly cumbersome in routine work, NPD has a distinct sensitivity advantage over FID for these alkaloids. An injector of the programmed temperature vaporizer (PTV) type permitted extension of the range of solvents which may be employed for the preparation of alkaloid samples for GC assays in which detection is to be accomplished by NPD.

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Section: Introductionmentioning

confidence: 99%

Nitrogen‐phosphorus detector potential in tropane alkaloid gas chromatography

Martinsen

Hiltunen

Huhtikangas

1992

Phytochemical Analysis

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show abstract

“…Concentrations of free and conjugated morphine in blood, in 20 cases of heroin-related deaths, have been reported (97) as well as unconjugated morphine concentrations in postmortem blood by RIA and GC/MS (98). A simplified GC method for the rapid determination of morphine in blood has been described which uses flash-heater methylation and GC-NPD (99). A site-dependence study of drug concentrations in postmortem blood has been reported (100).…”

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confidence: 99%