Rapid quantitation of SARS-CoV-2 antibodies in clinical samples with an electrochemical sensor

Timilsina, Sanjay Sharma; Durr, Nolan; Jolly, Pawan; Ingber, Donald E.

doi:10.1016/j.bios.2022.115037

Cited by 14 publications

(10 citation statements)

References 47 publications

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“…Timilsina et al [71] described a fast, multiplexed, electrochemical (EC) system with on-chip management that detects SARS-CoV-2 antibodies in less than 10 min utilising 1.5 μl of the patient specimen like dried blood spot (DBS) and plasma. The biosensor is covered with an antifouling nanoarchitecture material-based coating consisting of bovine serum albumin (BSA) and doped with extensively conducting pentaamine-altered graphene nanostructures cross-linked with glutaraldehyde (GA).…”

Section: Electrochemical-based Systems Relying On Nanomaterials and P...mentioning

confidence: 99%

Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment

Ahmed,

Ansari,

Siddiqui

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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A critical step in the process for preventing and identifying emergencies relating to health, safety, and welfare is the testing and quick diagnosis of microbial pathogens. Due to the fast spread of waterborne and food borne infections in society and the high costs associated with them, pathogen identification has emerged as one of the most difficult parts of the water and food sectors. Since the turn of the century, pathogens have demonstrated enormous epidemiological and pandemic potential. The emergence and dissemination of a novel virus with pandemic potential endanger the livelihoods and well-being of individuals worldwide. The severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) coronavirus pandemic has propagated to almost every country on Earth and has had a considerable negative influence on economies and communities. Despite improvements in identification techniques for viral diseases, all nations must now execute biosensing in a speedy, sensitive, focused, and consistent manner in order to address pressing global issues. Hence, in this review, we have critically summarised the recent advancement of electrochemical as well as optical biosensors for the monitoring of SARS-COV-2 and various pathogens. Then, we began by providing a technical overview of cutting-edge strategies utilised to combat diseases and emergencies for it, including the utilisation of point-of-care technology (POCT), artificial intelligence (AI), and the internet of medical things (IoMT). This review article explores the integration of POC, IoMT, and AI technologies in the context of personal healthcare, focusing on their potential to expedite the diagnosis and treatment of medical conditions, ultimately leading to improved patient outcomes. Subsequently, the notion and execution of multiplex testing are presented to enhance the comprehension of detecting multiple analytes. Finally, conclusions and future directions have been presented.

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Section: Electrochemical-based Systems Relying On Nanomaterials and P...mentioning

confidence: 99%

Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment

Ahmed,

Ansari,

Siddiqui

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…Timilsina et al [ 14 ], described an electrochemical device that can rapidly and quantitatively detect Abs against SARS-CoV-2 in clinic. This method was shown to be simple to use, economic, sensitive (100% sensitivity and specificity), and fast (10 min).…”

Section: Dynamic Changes In Sars-cov-2 Specic Antibodiesmentioning

confidence: 99%

“…Furthermore, it required blood samples of only 1.5 μL, and Abs could even be detected in dry blood spots. This test can be operated on-site and via remote application, and may have great promise in the future of COVID-19 testing[ 14 ].…”

Section: Dynamic Changes In Sars-cov-2 Specic Antibodiesmentioning

confidence: 99%

Clinical application of SARS-CoV-2 antibody detection and monoclonal antibody therapies against COVID-19

Sun¹,

Yang²,

Xie³

et al. 2023

World J Clin Cases

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The purpose of this study was to investigate the clinical application of severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) specific antibody detection and anti-SARS-CoV-2 specific monoclonal antibodies (mAbs) in the treatment of coronavirus infectious disease 2019 (COVID-19). The dynamic changes of SARS-CoV-2 specific antibodies during COVID-19 were studied. Immunoglobulin M (IgM) appeared earlier and lasted for a short time, while immunoglobulin G (IgG) appeared later and lasted longer. IgM tests can be used for early diagnosis of COVID-19, and IgG tests can be used for late diagnosis of COVID-19 and identification of asymptomatic infected persons. The combination of antibody testing and nucleic acid testing, which complement each other, can improve the diagnosis rate of COVID-19. Monoclonal anti-SARS-CoV-2 specific antibodies can be used to treat hospitalized severe and critically ill patients and non-hospitalized mild to moderate COVID-19 patients. COVID-19 convalescent plasma, highly concentrated immunoglobulin, and anti-SARS-CoV-2 specific mAbs are examples of anti-SARS-CoV-2 antibody products. Due to the continuous emergence of mutated strains of the novel coronavirus, especially omicron, its immune escape ability and infectivity are enhanced, making the effects of authorized products reduced or invalid. Therefore, the optimal application of anti-SARS-CoV-2 antibody products (especially anti-SARS-CoV-2 specific mAbs) is more effective in the treatment of COVID-19 and more conducive to patient recovery.

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“…In addition, electrochemical biosensors have also been used to detect antibodies generated aer SARS-CoV-2 infection, providing crucial information about the individual's immune response, and to detect viral antigens. 25,33 An antigen test looks for an active infection by detecting the presence of antigens from the SARS-CoV-2 virus. On the other hand, an antibody test looks for signs of a past infection by detecting antibodies produced by the host in response to the virus.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, electrochemical biosensors have also been used to detect antibodies generated after SARS-CoV-2 infection, providing crucial information about the individual's immune response, and to detect viral antigens. 25,33…”

Section: Introductionmentioning

confidence: 99%

An overview of electrochemical biosensors used for COVID-19 detection

Valerio,

Anastácio,

da Silva

et al. 2024

Anal. Methods

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Rapid quantitation of SARS-CoV-2 antibodies in clinical samples with an electrochemical sensor

Cited by 14 publications

References 47 publications

Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment

Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment

Clinical application of SARS-CoV-2 antibody detection and monoclonal antibody therapies against COVID-19

An overview of electrochemical biosensors used for COVID-19 detection

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