Rapid prototyping of shrinkable BOPS-based microfluidic devices

Fan, Yiqiang; Wang, Hongliang; Liu, Shicheng; Liu, Jingji; Gao, Kexin; Zhang, Yajun

doi:10.1007/s10404-018-2162-1

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…A new bonding technique using 2.5% ( w/w ) PMMA solution as an adhesive layer was developed to seal PMMA microfluidic channels with PC [ 131 ]. Fan et al proposed the bonding of biaxially oriented polystyrene (BOPS)-based microfluidics device using a layer of BOPS or a layer of polyester adhesive film [ 132 ].…”

Section: Indirect Bondingmentioning

confidence: 99%

Recent Advances in Thermoplastic Microfluidic Bonding

Giri

Tsao

2022

Micromachines

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Microfluidics is a multidisciplinary technology with applications in various fields, such as biomedical, energy, chemicals and environment. Thermoplastic is one of the most prominent materials for polymer microfluidics. Properties such as good mechanical rigidity, organic solvent resistivity, acid/base resistivity, and low water absorbance make thermoplastics suitable for various microfluidic applications. However, bonding of thermoplastics has always been challenging because of a wide range of bonding methods and requirements. This review paper summarizes the current bonding processes being practiced for the fabrication of thermoplastic microfluidic devices, and provides a comparison between the different bonding strategies to assist researchers in finding appropriate bonding methods for microfluidic device assembly.

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Section: Indirect Bondingmentioning

confidence: 99%

Recent Advances in Thermoplastic Microfluidic Bonding

Giri

Tsao

2022

Micromachines

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“…The channel width varied from 58 to 264 μm, and depths ranged from 14 to 136 μm. The standard deviation was lowest for a scan speed of 40–100 mm/s at powers between 1.8 and 3 W. Fan et al performed CO 2 ablation on PS to create microchannels where the channel width and depth ranged from 60 to 140 μm and from 20 to 150 μm, respectively [ 98 ]. If the biaxially oriented PS was used, the range of width ranged from 25 to 60 μm, and the depth ranged from 100 to 800 μm.…”

Section: Non-mold-based Techniquesmentioning

confidence: 99%

Fabrication of Polymer Microfluidics: An Overview

Juang

Chiu

2022

Polymers

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Microfluidic platform technology has presented a new strategy to detect and analyze analytes and biological entities thanks to its reduced dimensions, which results in lower reagent consumption, fast reaction, multiplex, simplified procedure, and high portability. In addition, various forces, such as hydrodynamic force, electrokinetic force, and acoustic force, become available to manipulate particles to be focused and aligned, sorted, trapped, patterned, etc. To fabricate microfluidic chips, silicon was the first to be used as a substrate material because its processing is highly correlated to semiconductor fabrication techniques. Nevertheless, other materials, such as glass, polymers, ceramics, and metals, were also adopted during the emergence of microfluidics. Among numerous applications of microfluidics, where repeated short-time monitoring and one-time usage at an affordable price is required, polymer microfluidics has stood out to fulfill demand by making good use of its variety in material properties and processing techniques. In this paper, the primary fabrication techniques for polymer microfluidics were reviewed and classified into two categories, e.g., mold-based and non-mold-based approaches. For the mold-based approaches, micro-embossing, micro-injection molding, and casting were discussed. As for the non-mold-based approaches, CNC micromachining, laser micromachining, and 3D printing were discussed. This review provides researchers and the general audience with an overview of the fabrication techniques of polymer microfluidic devices, which could serve as a reference when one embarks on studies in this field and deals with polymer microfluidics.

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“…Moreover, a heat-shrinkable polymer (particularly PS) has been successfully introduced to fabricate microchannels due to its low-cost, rapid fabrication process (several minutes) (as shown in Fig. 5a ), high transparency 71 , and tunable aspect ratio. Since the heat-shrink technique was first introduced in microchannel fabrication in 2008, the fabrication resolution of microchannels by the heat-shrink technique has greatly improved (as shown in Fig.…”

Section: Applicationsmentioning

confidence: 99%

“…Owing to their flexible tunability, heat-shrink SMPs could be utilized to create microchannels with different depths to strengthen the fluid dynamics efficiency. Yiqiang et al 71 carved biaxially oriented PS films (BOPS) with multiple depths and weirs by laser ablation and micromilling. Successive thermal shrinkage process implementations led to a finer microchannel with a 20 μm width.…”

Section: Applicationsmentioning

confidence: 99%

Progress of shrink polymer micro- and nanomanufacturing

Cui

2021

Microsyst Nanoeng

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Traditional lithography plays a significant role in the fabrication of micro- and nanostructures. Nevertheless, the fabrication process still suffers from the limitations of manufacturing devices with a high aspect ratio or three-dimensional structure. Recent findings have revealed that shrink polymers attain a certain potential in micro- and nanostructure manufacturing. This technique, denoted as heat-induced shrink lithography, exhibits inherent merits, including an improved fabrication resolution by shrinking, controllable shrinkage behavior, and surface wrinkles, and an efficient fabrication process. These merits unfold new avenues, compensating for the shortcomings of traditional technologies. Manufacturing using shrink polymers is investigated in regard to its mechanism and applications. This review classifies typical applications of shrink polymers in micro- and nanostructures into the size-contraction feature and surface wrinkles. Additionally, corresponding shrinkage mechanisms and models for shrinkage, and wrinkle parameter control are examined. Regarding the size-contraction feature, this paper summarizes the progress on high-aspect-ratio devices, microchannels, self-folding structures, optical antenna arrays, and nanowires. Regarding surface wrinkles, this paper evaluates the development of wearable sensors, electrochemical sensors, energy-conversion technology, cell-alignment structures, and antibacterial surfaces. Finally, the limitations and prospects of shrink lithography are analyzed.

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Rapid prototyping of shrinkable BOPS-based microfluidic devices

Cited by 9 publications

References 25 publications

Recent Advances in Thermoplastic Microfluidic Bonding

Recent Advances in Thermoplastic Microfluidic Bonding

Fabrication of Polymer Microfluidics: An Overview

Progress of shrink polymer micro- and nanomanufacturing

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