Rapid prototyping of microfluidic systems using a laser-patterned tape

Luo, Lingaï; Teo, C.Y.; Ong, Wee‐Liat; Tang, Kum Cheong; Cheow, Lih Feng; Yobaş, Levent

doi:10.1088/0960-1317/17/12/n02

Cited by 23 publications

(21 citation statements)

References 21 publications

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“…Rapid prototyping of the pump was realized by replicamoulding a planar channel in poly(dimethylsiloxane) (PDMS) with a laser-patterned grinding tape as the template (Duffy et al 1998;Luo et al 2007). The grinding tape 130 µm thick (Furukawa Electric, Japan) was first attached to a polished surface on a silicon substrate.…”

Section: Pump Prototypingmentioning

confidence: 99%

A self-contained fully-enclosed microfluidic cartridge for lab on a chip

Yobaş

Cheow

Tang

et al. 2009

Biomed Microdevices

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We describe a self-contained fully-enclosed cartridge for lab-on-a-chip applications where sample and reagents can be applied sequentially as is performed in a heterogeneous immunoassay, or nucleic acid extraction. Both the self-contained and fully-enclosed features of the cartridge are sought to ensure its safe use in the field by unskilled staff. Simplicity in cartridge design and operation is obtained via adopting a valveless concept whereby reagents are stored and used in the form of liquid plugs isolated by air spacers around a fluidic loop. Functional components integrated in the loop include a microfluidic chip specific to the target application, a novel peristaltic pump to displace the liquid plugs, and a pair of removable tubing segments where one is used to introduce biological sample and while the other is to collect eluant. The novel pump is fabricated through soft-lithography technique and works by pinching a planar channel under stainless-steel ball bearings that have been magnetically loaded. The utility of the cartridge is demonstrated for automated extraction and purification of nucleic acids (DNA) from a cell lysate on a battery-operated portable system. The cartridge shown here can be further extended to sample-in-answer-out diagnostic tests.

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Section: Pump Prototypingmentioning

confidence: 99%

A self-contained fully-enclosed microfluidic cartridge for lab on a chip

Yobaş

Cheow

Tang

et al. 2009

Biomed Microdevices

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“…These approaches include use of paper, 14 shrinky-dinks, 15,16 wax, 7 paraffin, 17 or glass. 18 Laser cut tape has been used for replica-molding 19 and to fabricate cost-effective optical biochips. 20 Also, advanced tape bonding techniques 21 and low-cost prototyping methods with micro-milling, 22 robotic cutter, 23 or simple personal craft cutter (e.g., Silhouette) have been developed.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic assembly kit based on laser-cut building blocks for education and fast prototyping

2015

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Here, we present an inexpensive rapid-prototyping method that allows researchers and children to quickly assemble multi-layered microfluidic devices from easily pre-fabricated building blocks. We developed low-cost (<$2) kits based on lasercut acrylic building block pieces and double-sided tape that allow users to generate water droplets in oil, capture living cells, and conduct basic phototaxis experiments. We developed and tested a 90-min lesson plan with children aged 12-14 yr and provide here the instructions for teachers to replicate these experiments and lessons. All parts of the kit are easy to make or order. We propose to use such easy to fabricate kits in labs with no access to current microfluidic tools as well as in classroom environments to get exposure to the powerful techniques of microfluidics. V C 2015 AIP Publishing LLC. [http://dx

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“…The recent development of rapid-prototyping methods for microstructured devices (Duffy et al 1998;Khoury et al 2002;Itoga et al 2006;Luo et al 2007;Kim et al 2009;Jenness et al 2010;Do et al 2011) has provided several ways to fabricate and test microfluidic devices cheaply and easily. In particular, "liquid molding" of PDMS elastomer (Chao et al 2007;Liu et al 2009;Lu et al 2011), which harnesses the immiscibility between aqueous solutions and silicone oil, has provided a novel way to fabricate smooth, streamlined microstructures by utilizing the liquidity of the molds exploiting the ease of fabrication.…”

Section: Introductionmentioning

confidence: 99%