Rapid prototyping of microfluidic chip with burr-free PMMA microchannel fabricated by revolving tip-based micro-cutting

Xue, Binxia; Geng, Yanquan; Yan, Yongda; Ma, Gaojie; Wang, Dong; He, Yang

doi:10.1016/j.jmatprotec.2019.116468

Cited by 18 publications

(7 citation statements)

References 38 publications

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“…The micropatterning techniques for thermoplastics can be generally classified into two categories, i.e., direct manufacturing methods and molding methods. The direct manufacturing methods cover 3D printing, laser engraving, and micromilling on plastic substrates. − Micromilling allows for fabricating plastic microstructures with good resolution but also requires expensive equipment and complex optimization for each geometry . 3D printing and laser engraving are more affordable but can hardly produce microstructures less than 100 μm with sufficient precision.…”

Section: Introductionmentioning

confidence: 99%

Patterning High-Resolution Microstructures on Thermoplastics by Ceramic Nanoparticles Filled Epoxy Coated Molds for Duplicating Nature-Derived Functional Surfaces

Huang

Wang

Liu

et al. 2022

ACS Appl. Mater. Interfaces

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Patterning high-resolution microstructures on thermoplastic substrates is of fundamental importance for the commercialization of microfluidics, advanced functional surfaces, and optical elements. Though many methods are developed to fabricate micropatterned plastic devices with 100 μm resolution, they suffer substantially higher cost or lower productivity when the resolution of the micropatterns is to be further improved. Here, we develop low-cost molds consisting of thin ceramic-filled-epoxy composite coatings on steel substrates. By virtue of the loaded ZrO 2 nanoparticle fillers, the enhanced mechanical and thermal properties of the composite molds enable the epoxy microstructures to survive harsh conditions in conventional thermoplastic processing methods including hot embossing, imprinting, and mold injection. With the ceramic-filled-epoxy coated molds, we are able to improve the fabrication resolution of microstructures on plastics to 10 μm with unprecedented low-cost and excellent durability.

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Section: Introductionmentioning

confidence: 99%

Patterning High-Resolution Microstructures on Thermoplastics by Ceramic Nanoparticles Filled Epoxy Coated Molds for Duplicating Nature-Derived Functional Surfaces

Huang

Wang

Liu

et al. 2022

ACS Appl. Mater. Interfaces

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“…Unfortunately, the flow passage with a single configuration cannot produce a complicated flow microchannels. Correspondingly, the production of chips is based on ceramic plate printing-PDMS pouring method, which was able to manufacture micromicrochannels with complex configurations [8]. Inadequacy, the microchannel production process is demanding.…”

Section: Introductionmentioning

confidence: 99%

A Method for Manufacturing Flexible Microfluidic Chip Based on Soluble Material

Wang

Chen

Liu

et al. 2021

Journal of Nanomaterials

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In this paper, a novel method for manufacturing flexible microfluidic chips without bonding process is proposed, which combines 3D printing technology and material dissolution technology. The manufacturing process of the microfluidic chip is as follows: a soluble HIPS mold with a preset shape is manufactured by 3D printing and placed in a molten PDMS solution for solidification. Soak in the limonene material to dissolve the mold and form a microchannel in the cured PDMS. Experimental studies have shown that the temperature and concentration of the limonene solution have an important effect on the dissolution rate. A 0.62 cm3 HIPS mold has the fastest dissolution rate at 100°C and 50% concentration. The proposed method provided a new idea for fabricating flexible microfluidic chip. Compared to bonding process, it has the characteristics of not relying on complicated processing conditions and low manufacturing cost.

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“…In the last decade, a considerable effort has been dedicated to developing microfluidic devices made of hard thermoplastics such as polystyrene (PS) and Cyclic Olefin Copolymer (COC) to bridge microfluidics and life sciences 9‐14 . These polymers can be machined to make devices in few minutes in best configuration by computer numerical control machining, 15 industrial hot embossing, 16,17 or injection molding, 18 without taking into account the long heating or cooling cycles. There are now commercially available microfluidic platforms fabricated with these polymers.…”

Section: Introductionmentioning

confidence: 99%

Facile engineering and interfacing of styrenic block copolymers devices for low‐cost, multipurpose microfluidic applications

Salmon

Rasouli

DiStasio

et al. 2021

Engineering Reports

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Soft thermoplastic elastomers (sTPE) and specifically styrenic block copolymers (SBC) are making rapid progress in the prototyping and mass production of microfluidic chips. However, these new materials lack guidelines and protocols for chips fabrication, curbing their widespread applications compared to polydimethylsiloxane. In this work, the prototyping potential of a commercially available SBC material, Flexdym, for continuous flow applications is explored. This SBC material exhibits both reversible and permanent self‐adhesion depending on the time and bonding temperature, allowing for rapid and adaptive chip fabrication. Replicates are embossed in 2 min, assembled and sealed in 10 min. Under continuous flow, stud interfaces fabricated with this method can withstand 1 bar with reversible bonding and up to 3 bar after permanent bonding. The integration of an acoustic transducer in an SBC chip to induce acoustic streaming enables rapid mixing and local enrichment of polystyrene microparticles up to 8× the injected concentration. The reversible bonding feature of SBC chips allows to culture endothelial cells in open channels and then close and perfuse through channel to stain the cell. Our finding suggests that TPE‐based materials offer numerous possibilities for prototyping microfluidic chips for analytical and biomedical applications when working with continuous flow at high pressure is required.

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Rapid prototyping of microfluidic chip with burr-free PMMA microchannel fabricated by revolving tip-based micro-cutting

Cited by 18 publications

References 38 publications

Patterning High-Resolution Microstructures on Thermoplastics by Ceramic Nanoparticles Filled Epoxy Coated Molds for Duplicating Nature-Derived Functional Surfaces

Patterning High-Resolution Microstructures on Thermoplastics by Ceramic Nanoparticles Filled Epoxy Coated Molds for Duplicating Nature-Derived Functional Surfaces

A Method for Manufacturing Flexible Microfluidic Chip Based on Soluble Material

Facile engineering and interfacing of styrenic block copolymers devices for low‐cost, multipurpose microfluidic applications

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