Rapid prototyping of cyclic olefin copolymer based microfluidic system with CO2 laser ablation

Cai, Jianchen; Jiang, Jinyun; Gao, Feng; Jia, Guangnan; Zhuang, Jian; Tang, Gang; Fan, Yiqiang

doi:10.1007/s00542-017-3282-3

Cited by 25 publications

(20 citation statements)

References 23 publications

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“…polymer and paper. Currently, more organic and inorganic materials have been used in the fabrication of low-cost microfluidics such as elastomers [20], thermal plastics [21], thermoset [22], paper [23] and bio-materials [24]. On choosing the right materials for the low-cost microfluidic device, the following aspects need to be taken into consideration: the general physical properties, material cost, applications, surface wettability requirement, biocompatibility and chemical resistance.…”

Section: Materials For Low-cost Microfluidicsmentioning

confidence: 99%

Low‐cost microfluidics: materials and methods

Fan

2018

Micro & Nano Letters

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Microfluidics has been widely used in the biological, chemical and recently in the energy field. In the past decade, microfluidics has experienced tremendous growth in academia; researchers in various fields have been using microfluidics as a powerful tool for the enchantments of their research. However, the fabrication technologies of microfluidics are sourced from microelectromechanical systems and integrated circuit industry, which the fabrication process is costly and time-consuming, with the need of highly sophisticated instruments and experienced technical personnel to conduct fabrication process in the cleanroom environment. To lower the technical barriers for microfluidics, more and more researchers in different fields have invented various low-cost fabrication methods for microfluidics using polymers or paper materials. Comparing to the conventional microfabrication process conducted in the cleanroom, the low-cost fabrication methods are more flexible, with significant reduction in material cost, fabrication cost and processing time. This review is trying to introduce the most recent developments in low-cost microfluidics, from the aspects of materials, microfabrication and bonding technologies. The comparison and scope of application for different low-cost fabrication technologies for microfluidics were also provided in this review.

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Section: Materials For Low-cost Microfluidicsmentioning

confidence: 99%

Low‐cost microfluidics: materials and methods

Fan

2018

Micro & Nano Letters

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“…Silicon and glass are the earliest substrate materials used in microfluidic chips, mainly because they can directly use processing methods in the field of MEMS and microelectronics. Silicon and glass materials are expensive and difficult to process, which have been replaced by a variety of low-cost polymer materials, such as elastomer materials [25], thermoplastic polymers [26], thermosetting polymers [27], paper materials [28], biomaterials [29], etc. In this paper, the materials used for low cost microfluidic chip fabrication are divided into polymer materials, paper materials and other materials.…”

Section: Introductionmentioning

confidence: 99%

Application of Microfluidic Chip Technology in Food Safety Sensing

Gao

Yan

et al. 2020

Sensors

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Food safety analysis is an important procedure to control food contamination and supervision. It is urgently needed to construct effective methods for on-site, fast, accurate and popular food safety sensing. Among them, microfluidic chip technology exhibits distinguish advantages in detection, including less sample consumption, fast detection, simple operation, multi-functional integration, small size, multiplex detection and portability. In this review, we introduce the classification, material, processing and application of the microfluidic chip in food safety sensing, in order to provide a good guide for food safety monitoring.

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“…Laser-based fabrication has become a powerful technique for the production of microfluidic devices [ 7 , 8 , 19 ], and the 10.6

m emission of CO

lasers provides an effective way of patterning materials, particularly polymers and oxides. From its initial demonstration [ 20 ] in application to PMMA, CO

laser patterning has been applied to a very wide range of microfluidic materials such as glass [ 21 ], quartz [ 22 ], PDMS [ 23 ], polytetrafluoroethylene (PTFE [ 24 ]), polystyrene (PS [ 25 ]), polycarbonate (PC [ 26 ]), polyester/polyethylene terephthalate (PET [ 27 ]), cyclic olefin copolymer (COC [ 28 ]), paper [ 29 ] and laminates, both polymeric [ 30 ] and co-fired green ceramics [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

CO2 Laser-Based Rapid Prototyping of Micropumps

Strike

Ghofrani²,

Backhouse

2018

Micromachines

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The fabrication of microdevices for fluidic control often requires the use of flexible diaphragms in a way that requires cleanroom equipment and compromises performance. We use a CO2 laser to perform the standard ablative techniques of cutting and engraving materials, but we also apply a method that we call laser placement. This allows us to fabricate precisely-positioned and precisely-sized, isolated diaphragms. This in turn enables the rapid prototyping of integrated multilayer microfluidic devices to form complex structures without the need for manual positioning or cleanroom equipment. The fabrication process is also remarkably rapid and capable of being scaled to manufacturing levels of production. We explore the use of these devices to construct a compact system of peristaltic pumps that can form water in oil droplets without the use of the non-pulsatile pumping systems typically required. Many devices can be fabricated at a time on a sheet by sheet basis with a fabrication process that, to our knowledge, is the fastest reported to date for devices of this type (requiring only 3 h). Moreover, this system is unusually compact and self-contained.

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Rapid prototyping of cyclic olefin copolymer based microfluidic system with CO2 laser ablation

Cited by 25 publications

References 23 publications

Low‐cost microfluidics: materials and methods

Low‐cost microfluidics: materials and methods

Application of Microfluidic Chip Technology in Food Safety Sensing

CO2 Laser-Based Rapid Prototyping of Micropumps

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