Rapid Prototyping of Chemical Microsensors Based on Molecularly Imprinted Polymers Synthesized by Two‐Photon Stereolithography

Abstract

Two-photon stereolithography is used for rapid prototyping of submicrometre molecularly imprinted polymer-based 3D structures. The structures are evaluated as chemical sensing elements and their specific recognition properties for target molecules are confirmed. The 3D design capability is exploited and highlighted through the fabrication of an all-organic molecularly imprinted polymeric microelectromechanical sensor.

Functionalized 3D Architected Materials via Thiol‐Michael Addition and Two‐Photon Lithography

“…[35] A more modern approach has been to synthesize monomers with the functional groups of interest. By carefully designing the monomers such that the desired functional groups are not consumed during the polymerization process, structures with unique properties such as photo-reactive surfaces, [37-39] intrinsic chemical sensing, [40] chemical resistance, [41] bioactivity [42-43] and biodegradability [44-45] can be fabricated. Since the functional groups are directly installed onto the monomer, they should exhibit a higher surface density of functional groups.…”

Advances and Future Perspectives in 4D Bioprinting

“…Three‐dimensional printing technologies have already been used to make biosensors. For example, Gomez et al used a two‐photon stereolithography approach to fabricate microcantilever‐based biosensors using molecularly imprinted polymers. Similarly, Credi et al used stereolithography technique to make cantilevers containing magnetic nanocomposites.…”

Two‐Photon Initiating Efficiency of a Ditopic Alkoxynitrostilbene Reacting through a Self‐Regenerative Mechanism

“…Twophoton initiated polymerization has progressed rapidly as an advanced 3D printing technology which offers a high-quality level writing of complex, 3D structures with feature sizes reaching sub-100 nm scale. [3,4] The research in 3D nano/microfabrication is highly active owing to its promising applications such as high-density 3D optical data storage, [5][6][7] biomaterials for regenerative medicine, [8] photonic crystals, [9] 3D sensors [10,11] and the like. In the framework of the free radical polymerization, an efficient two-photon initiated reaction implies the use of chromophores which both exhibit a large two-photon absorption cross-section (δ) and an efficient photoreactivity leading to a high yield (Φ i ) for the generation of primary free radicals.…”