Rapid prototyping and manufacturing for tissue engineering scaffolds

Bartolo, Paulo Jorge Da Silva; Almeida, Henrique A.; Laoui, Tahar

doi:10.1504/ijcat.2009.026664

Cited by 61 publications

(37 citation statements)

References 29 publications

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“…In some cases, supports are necessary to brace overhangs, which in this case, the system's proprietary software performs the design of the support structures. The model is then sliced and the sliced data is then sent to the additive hardware machine for the production of the final physical part [8,19]. The information flowchart is illustrated below in Fig.…”

Section: Additive Manufacturingmentioning

confidence: 99%

Sustainability in extrusion-based additive manufacturing technologies

et al. 2016

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Growing environmental and social concerns about human society's impact on the natural environment have been pushing sustainable development issues into the front line of public policies. The degradation of natural resources has been aggravated by several other factors: the actual lifestyle of consumer societies, the rapid growth of emerging countries, rising inequalities among regions, and the reduction of the life cycle time for each product requiring a high consumption of limited resources. Sustainable industrial practices can contribute to the development of more sustainable products and processes. It is critical to apply eco-design principles and develop greener products and production processes, reducing impacts associated with its production and consumption. An environmental impact assessment should be taken into account from the early design and production phases, through all the stages of a product's life until disposal. As public interest in additive manufacturing grows, its increasing usage for the production of final parts can support a drive towards more sustainable manufacturing processes. To introduce sustainability awareness during extrusion-based additive manufacturing productions, a study of the production of a part in terms its building orientation and internal filling, regarding the production time, energy consumption and end-of-life scenarios is considered. By combining the additive processes with eco-design, a higher awareness is possible, which results in added value to the produced parts while maintaining the part's objective performance.

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Section: Additive Manufacturingmentioning

confidence: 99%

Sustainability in extrusion-based additive manufacturing technologies

et al. 2016

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“…It must serve as an adhesion substrate for cells, allowing cell attachment, proliferation and differentiation; it must deliver and retain cells and growth factors; it has to enable diffusion of cell nutrients and oxygen; and must provide temporary mechanical and biological environment to the newly grown tissue enabling tissue regeneration in an organized way (Billiet et al, 2012;Truscello et al, 2012;Guillotin and Guillemot, 2011;Bártolo et al, 2009a;2009b;Tan and Teoh, 2007;Liu and Czernuszka, 2006;Kreke et al, 2005;Gomes and Reis, 2004;Gross and RodriguezLorenzo, 2004;Leong et al, 2003;Kreeger and Shea, 2002;Hutmacher, 2001;Kim and Mooney, 2001;Langer and Vacanti, 1993). In order to accomplish all this goals, the scaffolds must fulfil several biological and physical requirements ( Table 3) that will affect cell survival, signalling, growth, propagation and reorganization and also cell shape modelling and gene expression (Bártolo et al, 2012;Billiet et al, 2012;Reverchon and Cardea, 2012;Vasanthan et al, 2012;Bártolo et al, 2009a;2009b;Sanz-Herrera et al, 2009;Leong et al, 2008;Chen et al, 1997;Mooney et al, 1992). Table 3 Relationship between scaffold characteristics and the corresponding biological effect (Mahajan, 2005).…”

Section: Figurementioning

confidence: 99%

“…Tissue Engineering is an emerging field that complies different areas of science focusing essentially on the use of cells, biomaterials, computational methods and fabrication processes ( Figure 1) merging principles of areas such as biology, engineering and medicine in order to create biological tissues that are functionally defective or damaged (Eshraghi and Das, 2010;Bártolo et al, 2009a;2009b;Gibson, 2005;Tan et al, 2005;Vozzi et al, 2003;Risbud, 2001). Skalak and Fox (1988), defined Tissue Engineering as the "application of the principles and methods of engineering and life sciences toward the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain, or improve tissue and organ functions" (Bártolo et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Relationship between implant primary stability (torque and ISQ) and bone density assessed by CBCT—clinical trial

2014

Biodental Engineering III

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AgradecimentosAo Professor Doutor Henrique Almeida, meu orientador e grande amigo, a quem agradeço a sua generosa paciência, exigência e ambição. Os contínuos estímulos para prosseguir este trabalho e o contínuo apoio moral e cientifico foram sempre determinantes para que continuasse a desenvolver esta dissertação. Agradeço profundamente a amizade com que me prendou durante todos estes anos do meu percurso académico e profissional, que revelam uma pessoa dedicada, competente e honesta.Ao Professor Doutor Paulo Bártolo, meu co-orientador, meu amigo, meu chefe e meu exemplo pessoal e profissional. Palavras são parcas para descrever o meu profundo agradecimento não só pelo constante apoio profissional e académico bem como pessoal. Agradeço todas as orientações científicas que me deu na realização deste trabalho bem como todo o rigor e contributo crítico ao longo de toda a minha vida profissional e académica. A sua constante disponibilidade para me auxiliar tornam todas as minhas etapas sempre mais fáceis de superar.Agradeço a todos os meus familiares e amigos por todo o apoio, contributo e incentivo prestado e por estarem sempre presentes quando mais preciso e principalmente por compreenderem os meus momentos de constante ausência. Agradeço especialmente ao André Vieira, Joana Maia, João Pascoal, Carolina Luís, Paulo Carvalho, Tânia Luís, Sérgio Santos, Vítor Hugo, Jair Cruz e Ruben Santos por estarem sempre presentes, mesmo sem pedir nada em troca (às vezes).À Ana Rita por todo o apoio e motivação em todo o meu percurso académico e profissional.Foi graças à sua extrema paciência e compreensão, especialmente quando mais tive ausente, e também do seu contínuo apoio ao longo de todos estes anos que foi possível chegar até aqui.Acreditou sempre no meu valor e deu-me sempre a força necessária para ir superando os meus obstáculos. Obrigado.Ao Alexandre, meu irmão e meu melhor amigo. Por me apoiar incondicionalmente e perdoar todos os meus momentos de ausência. Por me apoiar mesmo sem palavras. Agradeço a boa disposição e acima de tudo o amor de "maninho" com que me presenteia diariamente. v DINO MIGUEL FERNANDES FREITASPor último, aos meus Pais, principalmente por estarem presentes. Por me apoiarem incondicionalmente e darem-me a força necessária para continuar a lutar pelo que quero. Por me alegrarem e animarem nos momentos mais difíceis e por nunca me deixarem baixar os braços acreditando sempre em mim e principalmente por me apoiarem no percurso que escolhi.Agradeço há minha mãe pela amizade de uma amiga e o amor de uma mãe. Agradeço ao meu pai pelos sacrifícios e determinação nas vitórias por quem ama.A todos, o meu mais sincero agradecimento. vi OPTIMIZATION OF A PERFUSION BIOREACTOR FOR TISSUE ENGINEERING ResumoA regeneração de tecidos e/ou de órgãos é a solução para colmatar a falta de órgãos e tecidos, tanto actualmente como num futuro próximo. Este domínio da medicina tem crescido bastante e tem substituído algumas terapias convencionais. Os seus principais objectivos são restaurar, manter ou melhorar as funçõe...

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“…Thus, the scaffold plays a fundamental role in most tissue engineering strategies as its properties can greatly influence the overall success of new tissue formation. Therefore, the controlled fabrication of scaffold structures is becoming increasingly important in these modern approaches to regenerative medicine (46,47).…”

Section: Biodevices For Tissue Engineeringmentioning

confidence: 99%

Rapid Prototyping for Biomedical Engineering: Current Capabilities and Challenges

Lantada

Morgado

2012

Annu. Rev. Biomed. Eng.

152

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A new set of manufacturing technologies has emerged in the past decades to address market requirements in a customized way and to provide support for research tasks that require prototypes. These new techniques and technologies are usually referred to as rapid prototyping and manufacturing technologies, and they allow prototypes to be produced in a wide range of materials with remarkable precision in a couple of hours. Although they have been rapidly incorporated into product development methodologies, they are still under development, and their applications in bioengineering are continuously evolving. Rapid prototyping and manufacturing technologies can be of assistance in every stage of the development process of novel biodevices, to address various problems that can arise in the devices' interactions with biological systems and the fact that the design decisions must be tested carefully. This review focuses on the main fields of application for rapid prototyping in biomedical engineering and health sciences, as well as on the most remarkable challenges and research trends.

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Rapid prototyping and manufacturing for tissue engineering scaffolds

Cited by 61 publications

References 29 publications

Sustainability in extrusion-based additive manufacturing technologies

Sustainability in extrusion-based additive manufacturing technologies

Relationship between implant primary stability (torque and ISQ) and bone density assessed by CBCT—clinical trial

Rapid Prototyping for Biomedical Engineering: Current Capabilities and Challenges

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