Rapid production of block copolymer nano-objects via continuous-flow ultrafast RAFT dispersion polymerisation

Abstract

Continuous-flow reactors are exploited for conducting ultrafast RAFT dispersion polymerisation for the preparation of diblock copolymer nanoparticles.

RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions

“… 294 Warren et al reported the ultrafast continuous-flow RAFT dispersion polymerization which achieved conversions >90% within 8 minutes for target PDAAM DPs of 50 and 100, and achieved 79% conversion of DP of 200 within 20 minutes. 297 In the further study ( Fig. 16 ), PET-RAFT dispersion polymerization with oxygen tolerance employing eosin Y/triethanol amine as catalytic system was exploited for the synthesis of poly(dimethyl acrylamide)- b -(poly(diacetone acrylamide)- co -poly(dimethyl acrylamide)) (PDMAA- b -(PDAAm- co -PDMAA)) in one-step continuous-flow process without intermediate purification.…”

Machine Learning-Guided Discovery of 19F MRI Agents Enabled by Automated Copolymer Synthesis

“…A common challenge for high-throughput radical polymerization is the need to rigorously remove oxygen from each sample and, thus, limit batch to batch variability. [99][100][101][102][103][104][105] We took inspiration from the "polymerizing through" approach [106][107][108][109][110] to oxygen-tolerant RAFT polymerization where a large flux of radicals is introduced at the start of the reaction to consume dissolved oxygen, and a smaller and consistent radical flux subsequently provides controlled polymerization. A high radical flux was achieved through the addition of a low concentration of V-70, an azo radical initiator with a short half-life at the reaction temperatures, in addition to the more typical radical initiator AIBN (See SI for detailed copolymerization methodology).…”

Machine Learning-Guided Discovery of 19F MRI Agents Enabled by Automated Copolymer Synthesis

“…A common challenge for high-throughput radical polymerization is the need to rigorously remove oxygen from each sample and, thus, limit batch to batch variability. [99][100][101][102][103][104][105] We took inspiration from the "polymerizing through" approach [106][107][108][109][110] to oxygen-tolerant RAFT polymerization where a large flux of radicals is introduced at the start of the reaction to consume dissolved oxygen, and a smaller and consistent radical flux subsequently provides controlled polymerization. A high radical flux was achieved through the addition of a low concentration of V-70, an azo radical initiator with a short half-life at the reaction temperatures, in addition to the more typical radical initiator AIBN (See SI for detailed copolymerization methodology).…”