The total number of words of the manuscript, including entire text from title page to figure legends: 4300The number of words of the abstract: 237The number of figures: 4The number of tables: 1 2 Abstract This paper presents a methodology to align plantar pressure image sequences simultaneously in time and space. The spatial position and orientation of a foot in a sequence are changed to match the foot represented in a second sequence. Simultaneously with the spatial alignment, the temporal scale of the first sequence is transformed with the aim of synchronizing the two input footsteps. Consequently, the spatial correspondence of the foot regions along the sequences as well as the temporal synchronizing is automatically attained, making the study easier and more straightforward. In terms of spatial alignment, the methodology can use one of four possible geometric transformation models: rigid, similarity, affine or projective. In the temporal alignment, a polynomial transformation up to the 4 th degree can be adopted in order to model linear and curved time behaviors. Suitable geometric and temporal transformations are found by minimizing the mean squared error (MSE) between the input sequences. The methodology was tested on a set of real image sequences acquired from a common pedobarographic device. When used in experimental cases generated by applying geometric and temporal control transformations, the methodology revealed high accuracy. Additionally, the intra-subject alignment tests from real plantar pressure image sequences showed that the curved temporal models produced better MSE results (p<0.001) than the linear temporal model. This paper represents an important step forward in the alignment of pedobarographic image data, since previous methods can only be applied on static images.