Rapid Onset Neovascular Glaucoma due to COVID-19-related Retinopathy

Soman, Manoj; Indurkar, Asmita; Thomas, George; Sheth, Jay; Nair, Unnikrishnan

doi:10.5005/jp-journals-10078-1356

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[14] Most of the suspected physiopathological associations between COVID-19 and glaucoma have been case reports. [15][16][17][18] Interestingly, more data are available on the remarkable ocular adverse effects (ADEs) of COVID-19 vaccines. Angle-closure glaucoma is 1 of the 3 most frequent ADEs with AZD-1222, [19] and case reports related to this ADEs [20][21][22][23] have arisen, although there is a short interval between the injection and the onset of ADEs.…”

Section: Introductionmentioning

confidence: 99%

Mendelian randomization supports causality between COVID-19 and glaucoma

Chen,

Zhang,

Yao

et al. 2024

Medicine

View full text Add to dashboard Cite

To determine whether there is a causal relationship between Corona Virus Disease 2019 (COVID-19) and glaucoma, a 2-sample Mendelian Randomization (MR) design was applied with the main analysis method of inverse-variance-weighted. The reliability of the results was checked using the heterogeneity test, pleiotropy test, and leave-one-out method. Four sets of instrumental variables (IVs) were used to investigate the causality between COVID-19 and glaucoma risk according to data from the IEU Genome Wide Association Study (GWAS). The results showed that 2 sets of COVID-19(RELEASE) were significantly associated with the risk of glaucoma [ID: ebi-a-GCST011071, OR (95% CI) = 1.227 (1.076–1.400), P = .002259; ID: ebi-a-GCST011073: OR (95% CI) = 1.164 (1.022–1.327), P = .022450; 2 sets of COVID-19 hospitalizations were significantly associated with the risk of glaucoma (ID: ebi-a-GCST011081, OR (95% CI) = 1.156 (1.033–1.292), P = .011342; ID: ebi-a-GCST011082: OR (95% CI) = 1.097 (1.007–1.196), P = .034908)]. The sensitivity of the results was acceptable (P > .05) for the 3 test methods. In conclusion, this MR analysis provides preliminary evidence of a potential causal relationship between COVID-19 and glaucoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Mendelian randomization supports causality between COVID-19 and glaucoma

Chen,

Zhang,

Yao

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

Viral infections and pathogenesis of glaucoma: a comprehensive review

Ahmad,

Deshmukh,

Webel

et al. 2023

Clin Microbiol Rev

View full text Add to dashboard Cite

SUMMARY Glaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-zoster virus, cytomegalovirus, rubella virus, dengue virus, chikungunya virus, Ebola virus, and, more recently, Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), have been associated with sequela of either primary or secondary glaucoma. Epidemiological and clinical studies suggest the association between these viruses and subsequent glaucoma development. Despite this, the ocular manifestation and sequela of viral infections are not well understood. In fact, the association of viruses with glaucoma is considered relatively uncommon in part due to underreporting and/or lack of long-term follow-up studies. In recent years, literature on the pathological spectrum of emerging viral infections, such as ZIKV and SARS-CoV-2, has strengthened this proposition and renewed research activity in this area. Clinical studies from endemic regions as well as laboratory and preclinical investigations demonstrate a strong link between an infectious trigger and development of glaucomatous pathology. In this article, we review the current understanding of the field with a particular focus on viruses and their association with the pathogenesis of glaucoma.

show abstract

Rapid Onset Neovascular Glaucoma due to COVID-19-related Retinopathy

Cited by 2 publications

References 19 publications

Mendelian randomization supports causality between COVID-19 and glaucoma

Mendelian randomization supports causality between COVID-19 and glaucoma

Viral infections and pathogenesis of glaucoma: a comprehensive review

Contact Info

Product

Resources

About