Rapid Normalization of the Dexamethasone Suppression Test with Mianserin

King, Doug; Devaney, N.; Cooper, S.J.

doi:10.1097/00004850-198704000-00003

Cited by 3 publications

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“…If there is an acute reduction of COR and ACTH secretion patterns in depressive patients also, it might be of interest whether these endocrinological effects are related to clinical outcome. In this context it has to be mentioned that mianserin, the precursor in the development of mirtazapine with similar biochemical properties, has been shown to rapidly normalize non-suppression during the dexamethasone-suppression test in depressed patients (King et al 1987). In addition to new pharmacological approaches such as CRH 1 receptor antagonists (Holsboer 2000), mirtazapine may also be an effective strategy to restore HPA system dysregulation in depression.…”

Section: Discussionmentioning

confidence: 99%

The influence of mirtazapine on anterior pituitary hormone secretion in healthy male subjects

et al. 2002

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Since the acute inhibition of COR secretion in the healthy volunteers was paralleled by a simultaneous decrease of ACTH release, central mechanisms (for example, inhibition of hypothalamic CRH output) are suggested to be responsible for the inhibitory effects of mirtazapine on COR secretion. Our results are of particular interest in the light of the hypercortisolism observed in depressed patients and new pharmacological approaches such as CRH(1) receptor antagonists.

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Section: Discussionmentioning

confidence: 99%