Rapid, Nondestructive Near-Infrared Assay for Water in Sealed Dimethyl Sulfoxide Compound Repository Containers

Abstract

Water contamination in dimethyl sulfoxide (DMSO) compound libraries is a recognized problem in the pharmaceutical industry. We describe a nondestructive, near-infrared (NIR) assay for water contamination inside the sealed containers used for compound libraries. This assay does not require opening the containers. We also report our observation of the permeation of water from laboratory air through the sealed container and into the DMSO solution over a period of months, as well as the rate of water absorption by DMSO directly exposed to laboratory air.

On-Line Application of Near-Infrared Spectroscopy for Monitoring Water Levels in Parts per Million in a Manufacturing-Scale Distillation Process

“…12,13 Quantitative NIRS models for determining water concentrations in parts per million have been previously reported for off-line bench analyses of organic solvents. 14–17 Although bench-top methods have reported the determination of trace levels of water, to the authors' best knowledge, on-line application of NIRS to determine water concentrations in parts per million in organic solvents has not been reported to date. In addition, considering the primary focus here is to develop an in situ NIRS method for water analysis followed by transfer to a manufacturing facility with operations five orders of magnitude larger in volumetric scale, the nature of the technical transfer introduces additional complexities into the development of the method relative to that intended for off-line applications (e.g., the practical constraints of testing a manufacturing-scale probe in development).…”