Rapid NETosis Is an Effector Mechanism to Combat Ocular Herpes Infection

Patil, Chandrashekhar D.; Borase, Hemant; Gagan, Satyashree; Sharma, Pankaj; Kapoor, Divya; Yadavalli, Tejabhiram; Jain, Sandeep; Joseph, Joveeta; Bagga, Bhupesh; Shukla, Deepak

doi:10.1167/iovs.65.6.36

Invest. Ophthalmol. Vis. Sci.

2024

DOI: 10.1167/iovs.65.6.36

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Rapid NETosis Is an Effector Mechanism to Combat Ocular Herpes Infection

Chandrashekhar D. Patil,

Hemant Borase,

Satyashree Gagan

et al.

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2024

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Cited by 1 publication

References 31 publications

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Neutrophils in Ocular Diseases

Bammidi,

Koontz,

Gautam

et al. 2024

IJMS

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Neutrophils, traditionally viewed as first responders to infection or tissue damage, exhibit dynamic and diverse roles in ocular health and disease. This review elaborates on previous findings that showed how neutrophils contribute to ocular diseases. In ocular infections, neutrophils play a pivotal role in host defense by orchestrating inflammatory responses to combat pathogens. Furthermore, in optic nerve neuropathies and retinal degenerative diseases like age-related macular degeneration (AMD) and diabetic retinopathy (DR), neutrophils are implicated in neuroinflammation and tissue damage owing to their ability to undergo neutrophil extracellular trap formation (NETosis) and secretion of inflammatory molecules. Targeting neutrophil-dependent processes holds promise as a therapeutic strategy, offering potential avenues for intervention in ocular infections, cancers, and retinal degenerative diseases. Understanding the multifaceted roles of neutrophils in ocular diseases is crucial for developing targeted therapies to improve patient outcomes.

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Neutrophils in Ocular Diseases

Bammidi,

Koontz,

Gautam

et al. 2024

IJMS

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Rapid NETosis Is an Effector Mechanism to Combat Ocular Herpes Infection

Cited by 1 publication

References 31 publications

Neutrophils in Ocular Diseases

Neutrophils in Ocular Diseases

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