Rapid multiplexed molecular phenotyping of<i>ex vivo</i>and<i>in vivo</i>tissues with targeted SERS NPs

Wang, Yu; Khan, Altaz; Som, Madhura; Leigh, Steven Y.; Wang, Danni; Chen, Ye; McVeigh, Patrick Z.; Wilson, Brian C.; Liu, Jonathan

doi:10.1117/12.2057716

Cited by 1 publication

(1 citation statement)

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“…In addition to detecting protein biomarkers in solutions or on cell membranes, SERS probes can also be employed for in vivo targeting of tumors. Up to now, in vivo tumor targeting experiments were all performed on animals (e.g., mouse xenografts). − SERS probes are decorated with tumor-specific ligands (e.g., antibodies) and injected into the animal models for “active” tumor targeting. That is, the injected SERS probes can target and bind to tumor sites via recognition between the targeting ligands and tumor biomarkers .…”

Section: Applications Of Sers-based Immunoassaymentioning

confidence: 99%

SERS-Activated Platforms for Immunoassay: Probes, Encoding Methods, and Applications

et al. 2017

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Owing to their excellent multiplexing ability, high sensitivity, and large dynamic range, immunoassays using surface-enhanced Raman scattering (SERS) as the readout signal have found prosperous applications in fields such as disease diagnosis, environmental surveillance, and food safety supervision. Various ever-increasing demands have promoted SERS-based immunoassays from the classical sandwich-type ones to those integrated with fascinating automatic platforms (e.g., test strips and microfluidic chips). As recent years have witnessed impressive progress in SERS immunoassays, we try to comprehensively cover SERS-based immunoassays from their basic working principles to specific applications. Focusing on several basic elements in SERS immunoassays, typical structures of SERS nanoprobes, productive optical spectral encoding strategies, and popular immunoassay platforms are highlighted, followed by their representative biological applications in the last 5 years. Moreover, despite the vast advances achieved to date, SERS immunoassays still suffer from some annoying shortcomings. Thus, proposals on how to improve the SERS immunoassay performance are also discussed, as well as future challenges and perspectives, aiming to give brief and valid guidelines for choosing suitable platforms according to particular applications.

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