Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

Leuschner, Florian; Rauch, Philipp J.; Ueno, Takamasa; Gorbatov, Rostic; Marinelli, Brett; Lee, Won Woo; Dutta, Partha; Wei, Ying; Robbins, Clinton S.; Iwamoto, Yoshiko; Sena, Brena F.; Chudnovskiy, Aleksey; Panizzi, Peter; Keliher, Edmund J.; Higgins, John M.; Libby, Peter; Moskowitz, Michael A.; Pittet, Mikaël J.; Świrski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias

doi:10.1084/jem.20111009

Cited by 441 publications

(484 citation statements)

References 53 publications

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“…By analyzing KikGR time-course data from destination tissues and the blood, we were able to determine the migration potential of specific cell populations. This approach provides new insights into cell migration in vivo and builds upon previous attempts to model monocyte tissue kinetics (14). In addition, Fucci mice provide a sensitive, realtime indication of progress through the cell cycle with no carryover of signal to daughter cells.…”

Section: Discussionmentioning

confidence: 96%

“…In tumor-bearing mice myeloid cells accumulate in the spleen (10)(11)(12), making this organ a candidate source of tumor-infiltrating cells. Recent reports propose that a rapidly mobilized reservoir of monocytes in the spleen contributes significant numbers of infiltrating cells in acute and chronic inflammatory conditions including myocardial infarction (13)(14)(15), stroke (14), atherosclerosis (15), and cancer (16,17). In cancer, extramedullary hematopoiesis in the spleen is suggested to sustain a continuous supply of monocytes to the tumor (16,17).…”

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confidence: 99%

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Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

Shand

Ueha

Otsuji

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

154

122

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Significance Solid tumors contain large numbers of immune cells, including monocytes and monocyte-derived macrophages that promote tumor progression. During tumor development, monocytes accumulate in the spleen. However, the influence of spleen cells on tumor growth remains controversial. Here, we used novel methods for tracking intertissue migration and monitoring hematopoiesis to show that during tumor development the bone marrow dramatically accelerates production of monocytes, rapidly transferring many of these newly formed cells to a reservoir in the spleen. However, these spleen monocytes are less able than their bone marrow counterparts to enter the tumor and make only a minor contribution to the tumor-infiltrating monocyte population. These findings clarify the roles of the spleen and bone marrow in cancer development.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

Shand

Ueha

Otsuji

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

154

122

View full text Add to dashboard Cite

show abstract

“…While monocytes are also formed in the liver and spleen [70][71][72], the view that monocytes are derived from the bone marrow has been established since the early 1960s and still dominates [73]. The monocytes produced from the bone marrow exit to the circulatory system in a C-C chemokine receptor 2 (CCR2)-dependent manner and enter tissues to give rise to tissue macrophages [74].…”

Section: Monocytes and Monocyte-derived Macrophagesmentioning

confidence: 99%

Microglia and Monocyte-Derived Macrophages in Stroke

2016

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Historically, the brain has been considered an immune-privileged organ separated from the peripheral immune system by the blood-brain barrier. However, immune responses do occur in the brain in neurological conditions in which the integrity of the blood-brain barrier is compromised, exposing the brain to peripheral antigens and endogenous danger signals. While most of the associated pathological processes occur in the central nervous system, it is now clear that peripheral immune cells, especially mononuclear phagocytes, that infiltrate into the injury site play a key role in modulating the progression of primary brain injury development. As inflammation is a necessary and critical component for the subsequent injury resolution process, understanding the contribution of mononuclear phagocytes on the regulation of inflammatory responses may provide novel approaches for potential therapies. Furthermore, predisposed comorbid conditions at the time of stroke cause the alteration of stroke-induced immune and inflammatory responses and subsequently influence stroke outcome. In this review, we summarize a role for microglia and monocytes/macrophages in acute ischemic stroke in the context of normal and metabolically compromised conditions.

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“…A B C a protective role (22). Accordingly, administration of the angiotensin-converting-enzyme inhibitor enalapril early after MI did not improve survival (23).…”

Section: Steady State Acute MI Chronic Mimentioning

confidence: 99%

Monocytes and macrophages in cardiac injury and repair

Sager¹,

Kessler²,

Schunkert³

2017

J. Thorac. Dis.

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Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

Abstract: IL-1b signaling augments continued splenic monocyte supply during acute inflammation.

Cited by 441 publications

References 53 publications

Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

Microglia and Monocyte-Derived Macrophages in Stroke

Monocytes and macrophages in cardiac injury and repair

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