2012
DOI: 10.1084/jem.20111009
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Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

Abstract: IL-1b signaling augments continued splenic monocyte supply during acute inflammation.

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Cited by 441 publications
(483 citation statements)
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References 53 publications
(85 reference statements)
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“…By analyzing KikGR time-course data from destination tissues and the blood, we were able to determine the migration potential of specific cell populations. This approach provides new insights into cell migration in vivo and builds upon previous attempts to model monocyte tissue kinetics (14). In addition, Fucci mice provide a sensitive, realtime indication of progress through the cell cycle with no carryover of signal to daughter cells.…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…By analyzing KikGR time-course data from destination tissues and the blood, we were able to determine the migration potential of specific cell populations. This approach provides new insights into cell migration in vivo and builds upon previous attempts to model monocyte tissue kinetics (14). In addition, Fucci mice provide a sensitive, realtime indication of progress through the cell cycle with no carryover of signal to daughter cells.…”
Section: Discussionmentioning
confidence: 96%
“…In tumor-bearing mice myeloid cells accumulate in the spleen (10)(11)(12), making this organ a candidate source of tumor-infiltrating cells. Recent reports propose that a rapidly mobilized reservoir of monocytes in the spleen contributes significant numbers of infiltrating cells in acute and chronic inflammatory conditions including myocardial infarction (13)(14)(15), stroke (14), atherosclerosis (15), and cancer (16,17). In cancer, extramedullary hematopoiesis in the spleen is suggested to sustain a continuous supply of monocytes to the tumor (16,17).…”
mentioning
confidence: 99%
“…While monocytes are also formed in the liver and spleen [70][71][72], the view that monocytes are derived from the bone marrow has been established since the early 1960s and still dominates [73]. The monocytes produced from the bone marrow exit to the circulatory system in a C-C chemokine receptor 2 (CCR2)-dependent manner and enter tissues to give rise to tissue macrophages [74].…”
Section: Monocytes and Monocyte-derived Macrophagesmentioning
confidence: 99%
“…A B C a protective role (22). Accordingly, administration of the angiotensin-converting-enzyme inhibitor enalapril early after MI did not improve survival (23).…”
Section: Steady State Acute MI Chronic Mimentioning
confidence: 99%