Rapid Microwave-Assisted Synthesis of pH-Sensitive Carbon-Based Nanoparticles for the Controlled Release of Doxorubicin to Cancer Cells

Dechsri, Koranat; Suwanchawalit, Cheewita; Chitropas, Padungkwan; Ngawhirunpat, Tanasait; Rojanarata, Theerasak; Opanasopit, Praneet; Pengnam, Supusson

doi:10.1208/s12249-023-02593-w

Cited by 5 publications

(3 citation statements)

References 66 publications

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“…Such liposomes can be easily absorbed by the enterocytes, allowing them to reach the circulatory system. PEG also increases the stability of liposomes in the blood, improving both their circulation and their drug release time [ 46 , 47 , 48 ]. A novelty in the field is represented by nanostructured lipid carriers (NLCs), a second generation of lipid carrier developed as an alternative to polymeric nanoparticles, liposomes, solid lipid nanoparticles, microparticles, and emulsions [ 49 ].…”

Section: Methodsmentioning

confidence: 99%

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Garbati,

Picco,

Magrassi

et al. 2024

Pharmaceutics

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The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted drug delivery is essential to tackle these diseases, improve therapy efficacy, and minimize side effects. Recent strategies have taken advantage of both active and passive nanocarriers, which are designed to protect the drug until it reaches the correct delivery site and to modulate drug release via the use of different physical–chemical strategies. In this systematic review, we present a literature overview of the different nanocarriers used for drug delivery in a set of chronic intestinal pathologies, highlighting the rationale behind the controlled release of intestinal therapies. The overall aim is to provide the reader with useful information on the current approaches for gut targeting in novel therapeutic strategies.

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Section: Methodsmentioning

confidence: 99%

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Garbati,

Picco,

Magrassi

et al. 2024

Pharmaceutics

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show abstract

“…11 This review (Table 1) will discuss classic pH-sensitive drug delivery systems separately, based on their triggering mechanisms. [12][13][14][15][16][17][18][19][20] However, it's important to note that the acidic nature of the pH in solid tumors raises some controversies concerning the efficacy and safety of pH-inducible delivery. As the use of pH-inducible delivery systems expands in both therapeutic and diagnostic fields, there is an urgent need for further exploration of the tumor microenvironment and the development of pH-triggering biorthogonal chemistry.…”

Section: Ph-responsive Nanoplatformsmentioning

confidence: 99%

“…Promote combination chemotherapy for cancer [12] Carbon-based nanoparticles Doxorubicin (DOX) Accelerate release of DOX at pH 5.0 Controlled drug release [13] Polypeptide-modified gold nanoclusters Photosensitizer chlorin e6 (Ce6)…”

Section: Micelles Ptx/doxmentioning

confidence: 99%