Rapid method for the quantitation of mivacurium isomers in human and dog plasma by using liquid chromatography with fluorescence detection: Application to pharmacokinetic studies

Lugo, Sonia I.; Eddington, Natalie D.

doi:10.1016/0731-7085(95)01684-8

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…The LC was a Hewlett-Packard series 1100 with a quaternary pump, autosampler, diode-array detector, and separate fluorescence detector. The LC was operated in a gradient mode using a chro-matographic system adopted from other investigators (5,8). The mobile phase used in this system contained octanesulfonic acid for its ion pairing abilities.…”

Section: Lc-flu Instrumental Conditionsmentioning

confidence: 99%

“…Compared to most other quaternary ammonium muscle blockers, mivacurium has a relatively short duration of action due to its rapid biotransformation by plasma cholinesterases (3,4). Its inactive metabolites are mivacurium esters (which exist as two isomers) and mivacurium alcohol (5). Figure 1 shows the structure of mivacurium and its metabolites.…”

Section: Introductionmentioning

confidence: 99%

“…Mivacurium is typically given intra- focused on detecting these compounds in serum using liquid chromatography-fluorescence detection (LC-FLU) (3,5,7,9,10). More recently, published procedures for quaternary ammonium compounds have focused on the use of LC-mass spectrometry (MS) or LC-MS-MS (8,(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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The Identification of Mivacurium and Metabolites In Biological Samples

Montgomery

LeBeau

Miller

et al. 2005

Journal of Analytical Toxicology

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Mivacurium is a muscle relaxant that is used in hospitals and has been implicated in a number of homicides. A validated, sensitive method for the analysis of mivacurium and metabolites from biological specimens is presented here. Sample cleanup involves the precipitation of proteins with acetonitrile followed by analyte isolation using a commercially available solid-phase extraction column. Screening is performed by liquid chromatography with fluorescence detection, and confirmation is performed by liquid chromatography with tandem mass spectrometric detection. This method has been used to analyze dozens of forensic samples, including clinical specimens from living patients, as well as autopsy specimens from exhumed bodies.

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Section: Lc-flu Instrumental Conditionsmentioning

confidence: 99%