Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry

Mitrowska, Kamila; Posyniak, Andrzej; Żmudzki, J.

doi:10.1016/j.aca.2008.10.030

Cited by 34 publications

(13 citation statements)

References 14 publications

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“…It has been reported that remifentanil and propofol itself, or combined with other drugs, may cause renal injury in healthy human patients [ 5 10 35 ]. Additionally, all pigs from all groups of our study were premedicated with azaperone, and this drug accumulates in pigs' kidneys and may also contribute to kidney damage [ 3 7 24 38 ]. A significant blood loss followed by volume replacement causes hemodilution.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

et al. 2018

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This work aimed to evaluate the effects on renal tissue integrity after hydroxyethyl starch (HES) 130/0.4 and Ringer's lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 (n = 11) received RL solution (25 mL/kg) and Group 2 (n = 11) received HES 130/0.4 solution (20 mL/kg). Additionally, Group 3 (n = 6) was not submitted to bleeding or volume replacement. Pigs were euthanized and kidneys were processed for histopathological and immunohistochemical analyses. Minimal to moderate glomerular, tubular, and interstitial changes, as well as papillary necrosis, were observed in all experimental groups. Pre-apoptosis and apoptosis indicators were higher in pigs that received HES 130/0.4, indicating a higher renal insult. Both HES 130/0.4 and RL administration may cause renal injury, although renal injury may be more significant in pigs receiving HES 13/0.4. Results also suggest that total intravenous anesthesia with propofol and remifentanil may cause renal injury, and this effect can be dose related.

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Section: Discussionmentioning

confidence: 99%

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

et al. 2018

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“…A review of the use of LC-MS in food safety has been published by Malik et al (2010). Methods have been described for thyreostats (Lõhmus et al 2009;Vanden Bussche et al 2010), beta-agonists (Williams et al 2004;Shao et al 2009), chloramphenicol (Rønning et al 2006), nitro-imidazoles (Radeck 2000;Berendsen et al 2002), nitrofurans (Radovnikovic et al 2011), anabolic steroids (Jodlbauer et al 2000;Van Poucke and Van Peteghem 2002;Yang et al 2009), polyether ionophores (Dubois et al 2004;Mortier et al 2005b;Olejnik et al 2009;Thompson et al 2011), quinolones (Berendsen et al 2004;Durden and MacPherson 2007;Schneider and Donoghue 2003), sedatives (Mitrowska et al 2009;Zhang et al 2009), anthelminthics (Danaher et al 2007;Durden 2007), NSAIDs (Gentili 2007;Dowling et al 2009;Malone et al 2009), corticosteroids (Chen et al 2010;Dusi et al 2011;Tölgyesi et al 2010) and coccidiostats (Mortier et al 2003;Dubois et al 2004;DubreilChéneau et al 2009;Olejnik et al 2009;Thompson et al 2011). Figure 7.3 shows the evolution of methods used in residue analysis over time.…”

Section: Analytical Methods For Drug Residue Controlmentioning

confidence: 97%

Veterinary drug residues in foods

Croubels

2012

Chemical Contaminants and Residues in Food

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“…Thus, gas chromatography-mass spectrometry (GC-MS) methods with or without derivatization have been reported for the determination of tranquilizers in matrices of animal origin [7,8]. Moreover, because of its high selectivity and sensitivity, the combination of liquid chromatography and tandem mass spectrometry (MS/MS) has been frequently adopted to detect these drugs in animal tissues or plasma [9,10,11,12,13,14,15,16,17,18]. Based on ultra-high-performance liquid chromatography (UHPLC) and time-of-flight mass spectrometry (TOF MS), a multiclass method was developed for screening and quantification of veterinary drugs, including eight tranquilizers in milk [19].…”

Section: Introductionmentioning

confidence: 99%

Determination of Tranquilizers in Swine Urine by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry

Wang

et al. 2018

Molecules

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A rapid, reliable, and sensitive method was developed for the determination of ten tranquilizers in swine urine. Sample preparation was based on solid-phase extraction, which combined isolation of the compounds and sample cleanup in a single step. Separation was performed on a reversed phase C18 column by gradient elution with a chromatographic run time of seven minutes, consisting of 0.1% formic acid in water and acetonitrile as the mobile phase. Multiple reaction monitoring in positive mode was applied for data acquisition. Matrix-matched calibration was used for quantification and good linearity was obtained with coefficients of determination higher than 0.99. The average recoveries of fortified samples at concentrations between 0.05 and 10 µg/L ranged from 85% to 106% with interday relative standard deviations of less than 13% in all cases. The limits of detection and limits of quantification obtained for tranquilizers in the urine were in the ranges of 0.03–0.1 µg/L and 0.05–0.25 µg/L, respectively. The applicability of the proposed method was demonstrated by analyzing real samples; diazepam was detected at concentrations between 0.3 and 0.6 μg/L.

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Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry

Cited by 34 publications

References 14 publications

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

Veterinary drug residues in foods

Determination of Tranquilizers in Swine Urine by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry

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