Rapid lipid enrichment in ω3 fatty acids: Plasma data

Carpentier, Yvon; Peltier, Sébastien; Portois, Laurence; Sener, Abdullah; Malaisse, Willy

doi:10.3892/ijmm.21.3.355

Cited by 9 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent data, including ours, show that the intravenous route strongly accelerates the incorporation into human cell membranes [4,11]. In rats the bolus administration of a novel MCT-FO solution achieves incorporation of n-3 PUFAs into cell membranes after only 60 min [12]. The data of the present study confirm these preliminary data and report combined pharmacological and biological data.…”

Section: Discussionsupporting

confidence: 87%

Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil

et al. 2009

View full text Add to dashboard Cite

Objective: To test the dose response effect of infused fish oil (FO) rich in n-3 PUFAs on the inflammatory response to endotoxin (LPS) and on membrane incorporation of fatty acids in healthy subjects. Design: Prospective, sequential investigation comparing three different FO doses. Subjects: Three groups of male subjects aged 26.8 ± 3.2 years (BMI 22.5 ± 2.1). Intervention: One of three FO doses (Omegaven Ò 10%) as a slow infusion before LPS: 0.5 g/kg 1 day before LPS, 0.2 g/kg 1 day before, or 0.2 g/kg 2 h before. Measurements and results: Temperature, hemodynamic variables, indirect calorimetry and blood samples (TNF-a, stress hormones) were collected. After LPS temperature, ACTH and TNF-a concentrations increased in the three groups: the responses were significantly blunted (p \ 0.0001) compared with the control group of the Pluess et al. trial. Cortisol was unchanged. Lowest plasma ACTH, TNF-a and temperature AUC values were observed after a single 0.2 g/kg dose of FO. EPA incorporation into platelet membranes was dose-dependent. Conclusions: Having previously shown that the response to LPS was reproducible, this study shows that three FO doses blunted it to various degrees. The 0.2 g/kg perfusion immediately before LPS was the most efficient in blunting the responses, suggesting LPS capture in addition to the systemic and membrane effects.

show abstract

Section: Discussionsupporting

confidence: 87%

Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The Materials and methods of the present study were already defined in the first report in this series (1).…”

Section: Methodsmentioning

confidence: 99%

“…In the first report in this series, the fatty acid pattern of plasma phospholipids, triglycerides, diglycerides and unesterified fatty acids was examined in rats depleted in long-chain polyunsaturated ω3 fatty acids and injected, or not, intravenously 60 min before sacrifice with either an ω3 fatty acid-rich middle-chain triglyceride:fish oil emulsion (MCT:FO) or a control ω3 fatty acid-poor middle-chain triglyceride:olive oil emulsion (MCT:OO) (1). The present report deals mainly with the changes observed, under these experimental conditions, in the fatty acid pattern of liver lipids in both male and female animals.…”

Section: Introductionmentioning

confidence: 99%

Rapid lipid enrichment in ω3 fatty acids: Liver data

Carpentier¹,

Peltier²,

Portois³

et al. 2008

Int J Mol Med

Self Cite

View full text Add to dashboard Cite

Abstract. The bolus intravenous injection of a novel mediumchain triglyceride:fish oil emulsion to normal subjects was recently reported to enrich within 60 min the phospholipid content of leucocytes and platelets in long-chain polyunsaturated ω3 fatty acids. The present study, conducted in second generation ω3-depleted rats, aims at investigating whether such a procedure may also increase within 60 min the phospholipid content of ω3 fatty acids in cells located outwards of the bloodstream, in this case liver cells, and whether this coincides with correction of the perturbation in the liver triglyceride fatty acid content and profile otherwise prevailing in these rats. The results indicate that such is indeed the case and further suggest a cause-to-effect relationship between the two events.

show abstract

“…The present study also allows to extend to C20:1ω9 the proposal that the liver phospholipid relative content in a given fatty acid may be judged from measurements conducted in plasma phospholipids (10), at least when comparing the mean values recorded in distinct groups of animals.…”

Section: Discussionmentioning

confidence: 99%

Perturbation of 11-eicosenoate metabolism in female diabetic rats

Malaisse¹,

Portois²,

Sener³

et al. 2008

Int J Mol Med

Self Cite

View full text Add to dashboard Cite

Abstract. Considering the proposed preventive effect of nervonic acid on obesity-and diabetes-related coronary risk factors, the content of its precursors (oleic, 11-eicosenoic and 13-docosenoic acids) was measured in liver and plasma phospholipids and triglycerides, brain and spleen phospholipids, and adipose tissue lipids of fed or overnight fasted control and hereditarily diabetic Goto-Kakizaki female rats, as well as fed streptozotocin-induced diabetic female rats. In liver and brain phospholipids, the 11-eicosenoate/oleate ratio was significantly higher in diabetic rats than in control animals. Such was not the case in either spleen phospholipids or liver triglycerides and adipose tissue lipids. The increase in the liver phospholipid 11-eicosenoate/oleate ratio found in female diabetic rats represents a mirror image of the situation recently documented, in the same animal models of diabetes, in male rats. These contrasting findings may be relevant to the higher coronary heart disease risk prevailing in female, as compared to male, diabetic subjects.

show abstract

Rapid lipid enrichment in ω3 fatty acids: Plasma data

Cited by 9 publications

References 8 publications

Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil

Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil

Rapid lipid enrichment in ω3 fatty acids: Liver data

Perturbation of 11-eicosenoate metabolism in female diabetic rats

Contact Info

Product

Resources

About