Rapid isotropic 3D‐sodium MRI of the knee joint in vivo at 7T

Wang, Ligong; Wu, Yan; Chang, Gregory; Oesingmann, Niels; Schweitzer, Mark E.; Jerschow, Alexej; Regatte, Ravinder R.

doi:10.1002/jmri.21881

Cited by 88 publications

(67 citation statements)

References 36 publications

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“…In large knee osteoarthritis trials, 1.0-T MR has been applied only in research. Field strength of 7.0 T has been used in only a few studies for the morphologic and compositional assessment of knee cartilage in humans (66,74,75). In the future, it may become possible to achieve higher resolution within a shorter acquisition time with 7.0-T systems than with 3.0-T systems.…”

Section: Mr Imaging Assessment Of Knee Cartilage With Different Fieldmentioning

confidence: 97%

Articular Cartilage in the Knee: Current MR Imaging Techniques and Applications in Clinical Practice and Research

et al. 2011

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Magnetic resonance (MR) imaging is the most important imaging modality for the evaluation of traumatic or degenerative cartilaginous lesions in the knee. It is a powerful noninvasive tool for detecting such lesions and monitoring the effects of pharmacologic and surgical therapy. The specific MR imaging techniques used for these purposes can be divided into two broad categories according to their usefulness for morphologic or compositional evaluation. To assess the structure of knee cartilage, standard spin-echo (SE) and gradient-recalled echo (GRE) sequences, fast SE sequences, and three-dimensional SE and GRE sequences are available. These techniques allow the detection of morphologic defects in the articular cartilage of the knee and are commonly used in research for semiquantitative and quantitative assessments of cartilage. To evaluate the collagen network and proteoglycan content in the knee cartilage matrix, compositional assessment techniques such as T2 mapping, delayed gadolinium-enhanced MR imaging of cartilage (or dGEMRIC), T1ρ imaging, sodium imaging, and diffusion-weighted imaging are available. These techniques may be used in various combinations and at various magnetic field strengths in clinical and research settings to improve the characterization of changes in cartilage.

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Section: Mr Imaging Assessment Of Knee Cartilage With Different Fieldmentioning

confidence: 97%

Articular Cartilage in the Knee: Current MR Imaging Techniques and Applications in Clinical Practice and Research

et al. 2011

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“…Indeed, a precise measurement of sodium concentration using sodium MRI necessitates the use of UTE or similar sequences owing to the rapid T 2 relaxation rate of the sodium nucleus [44]. SNR enhancement is also facilitated through the use of radial k-space acquisition trajectories [68,69], where the NMR signal is acquired immediately after excitation from the centre of the k-space and therefore does not undergo decay during the phase-encoding steps required in a conventional Cartesian k-space trajectory.…”

Section: Sodium Mrimentioning

confidence: 99%

Quantitative parametric MRI of articular cartilage: a review of progress and open challenges

Binks

Hodgson²,

Ries³

et al. 2013

The British Journal of Radiology

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With increasing life expectancies and the desire to maintain active lifestyles well into old age, the impact of the debilitating disease osteoarthritis (OA) and its burden on healthcare services is mounting. Emerging regenerative therapies could deliver significant advances in the effective treatment of OA but rely upon the ability to identify the initial signs of tissue damage and will also benefit from quantitative assessment of tissue repair in vivo. Continued development in the field of quantitative MRI in recent years has seen the emergence of techniques able to probe the earliest biochemical changes linked with the onset of OA. Quantitative MRI measurements including T 1 , T 2 and T 1r relaxometry, diffusion weighted imaging and magnetisation transfer have been studied and linked to the macromolecular structure of cartilage. Delayed gadolinium-enhanced MRI of cartilage, sodium MRI and glycosaminoglycan chemical exchange saturation transfer techniques are sensitive to depletion of cartilage glycosaminoglycans and may allow detection of the earliest stages of OA. We review these current and emerging techniques for the diagnosis of early OA, evaluate the progress that has been made towards their implementation in the clinic and identify future challenges in the field.

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“…However, their resonant frequency, relatively low SNR, and different relaxation behavior require the use of custom-tuned RF coils and specialized sequences that rapidly encode spatial frequency space to capture the signal. 26,30,92,93 …”

Section: Engineering Solutionsmentioning

confidence: 99%

Ultra-High-Field MR Neuroimaging

Balchandani

Naidich

2014

American Journal of Neuroradiology

141

138

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SUMMARY At ultra-high magnetic fields, such as 7T, MR imaging can noninvasively visualize the brain in unprecedented detail and through enhanced contrast mechanisms. The increased SNR and enhanced contrast available at 7T enable higher resolution anatomic and vascular imaging. Greater spectral separation improves detection and characterization of metabolites in spectroscopic imaging. Enhanced blood oxygen level–dependent contrast affords higher resolution functional MR imaging. Ultra-high-field MR imaging also facilitates imaging of nonproton nuclei such as sodium and phosphorus. These improved imaging methods may be applied to detect subtle anatomic, functional, and metabolic abnormalities associated with a wide range of neurologic disorders, including epilepsy, brain tumors, multiple sclerosis, Alzheimer disease, and psychiatric conditions. At 7T, however, physical and hardware limitations cause conventional MR imaging pulse sequences to generate artifacts, requiring specialized pulse sequences and new hardware solutions to maximize the high-field gain in signal and contrast. Practical considerations for ultra-high-field MR imaging include cost, siting, and patient experience.

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Rapid isotropic 3D‐sodium MRI of the knee joint in vivo at 7T

Cited by 88 publications

References 36 publications

Articular Cartilage in the Knee: Current MR Imaging Techniques and Applications in Clinical Practice and Research

Articular Cartilage in the Knee: Current MR Imaging Techniques and Applications in Clinical Practice and Research

Quantitative parametric MRI of articular cartilage: a review of progress and open challenges

Ultra-High-Field MR Neuroimaging

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