Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array

Burton, Scott A.; Ng, Chin-Yee; Simmers, Ryan; Moeckly, Craig; Brandwein, David; Gilbert, Tom; Johnson, Noye M.; Brown, Ken M.; Alston, Tesha; Prochnow, Gayatri; Siebenaler, Kris; Hansen, Kristen J.

doi:10.1007/s11095-010-0177-8

Cited by 102 publications

(61 citation statements)

References 14 publications

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“…These volumes were also much higher as those reported for single HMN in human skin (20 μL/HMN) (23) or HMN arrays in mice skin (0.22 μL/HMN) (26). Additionally, achieved volumes were comparable to HMN arrays in porcine skin (83.33 μL/ HMN) (27). Furthermore, a single hollow needle design reduces the risk of volume loss (dose loss) compared to HMN arrays, as in arrays all needles need to be penetrated and unclogged to ensure an accurate injection and prevent leakage (28,29).…”

Section: Discussionmentioning

confidence: 51%

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

et al. 2016

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Purpose The aim of this study was to investigate the depthdependent intradermal immunogenicity of inactivated polio vaccine (IPV) delivered by depth-controlled microinjections via hollow microneedles (HMN) and to investigate antibody response enhancing effects of IPV immunization adjuvanted with CpG oligodeoxynucleotide 1826 (CpG) or cholera toxin (CT). Methods A novel applicator for HMN was designed to permit depth-and volume-controlled microinjections. The applicator was used to immunize rats intradermally with monovalent IPV serotype 1 (IPV1) at injection depths ranging from 50 to 550 μm, or at 400 μm for CpG and CT adjuvanted immunization, which were compared to intramuscular immunization. Results The applicator allowed accurate microinjections into rat skin at predetermined injection depths (50-900 μm), -volumes (1-100 μL) and -rates (up to 60 μL/min) with minimal volume loss (±1-2%). HMN-mediated intradermal immunization resulted in similar IgG and virus-neutralizing antibody titers as conventional intramuscular immunization. No differences in IgG titers were observed as function of injection depth, however IgG titers were significantly increased in the CpG and CT adjuvanted groups (7-fold).Conclusion Intradermal immunogenicity of IPV1 was not affected by injection depth. CpG and CT were potent adjuvants for both intradermal and intramuscular immunization, allowing effective vaccination upon a minimally-invasive single intradermal microinjection by HMN.

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Section: Discussionmentioning

confidence: 51%

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

et al. 2016

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“…Opioid analgesics are the agents of choice to treat the severe pain associated with cancer. Since, the drug has to be administered frequently for a long period, the drug delivery system should be such that gives the maximum bioavailability of the drug, so that the patient gets the highest therapeutic benefit without getting exposed to high doses 8 .…”

Section: Acute and Chronic Painmentioning

confidence: 99%

“…These can be solid, hollow, fabricated from silicon material and plastic materials such as polycarbonates. Microneedles have hundreds of needles per array, ranging in size from 100 microns to 2 mm 8,92 .…”

Section: Microneedlementioning

confidence: 99%

Untitled

2017

IJPSR

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Pain is the major symptom associated with many diseases and disorders. Whether acute or chronic, pain causes much distress to the patient and can be debilitating in many cases. The quest for safe and effective pain management has driven the research efforts of the scientists for several decades. These ongoing efforts to come up with optimum therapeutic systems to deliver pain relief medication have propelled the researchers to explore different routes of drug administration, along with different means to facilitate drug delivery via a particular route. In view of the limitations of conventional methods to provide pain relief, as well as, the adverse effects associated with the traditional routes of drug delivery, the transdermal route of drug delivery has drawn the interest of scientists world over, owing to which a number of therapeutic breakthroughs have been achieved. In the past few decades, many novel drug delivery systems have been developed to deliver analgesics (NSAIDs and opioids) and anesthetics by means of transdermal therapy. The results obtained from the various studies attempted by the researchers suggest that the transdermal drug delivery systems are capable of causing significant reduction in pain levels, without causing gastrointestinal toxicity. As such, these systems can not only be made a part of the disease management strategy but also physical or chemical means. While the former involves the use of techniques like iontophoresis, electrophoresis, ultrasound, needleless injections and microneedles, the latter encompasses the use of chemical penetration enhancers to facilitate drug delivery across the skin. The present review attempts to furnish an overview of the physical techniques explored to deliver analgesics transdermally and the studies conducted in this domain.

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“…[25] A hilltop chamber was attached to the application site. After a 10-min staining period, the chamber was removed followed by washing with distilled water and observed for penetration.…”

Section: In-vivo Testmentioning

confidence: 99%

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2011

Journal of Pharmacy and Pharmacology

340

207

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Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings. Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area. Key findings Microneedles are fabricated using a microelectromechanical system employing silicon, metals, polymers or polysaccharides. Solid coated microneedles can be used to pierce the superficial skin layer followed by delivery of the drug. Advances in microneedle research led to development of dissolvable/degradable and hollow microneedles to deliver drugs at a higher dose and to engineer drug release. Iontophoresis, sonophoresis and electrophoresis can be used to modify drug delivery when used in concern with hollow microneedles. Microneedles can be used to deliver macromolecules such as insulin, growth hormones, immunobiologicals, proteins and peptides. Microneedles containing 'cosmeceuticals' are currently available to treat acne, pigmentation, scars and wrinkles, as well as for skin tone improvement. Summary Literature survey and patents filled revealed that microneedle-based drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional transdermal techniques.

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Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array

Cited by 102 publications

References 14 publications

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

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Microneedles: an emerging transdermal drug delivery system

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