Rapid Intake of Alcohol (Binge Drinking) Inhibits Platelet Adhesion to Fibrinogen Under Flow

Lange, Dylan W. de; Hijmering, Michael L.; Lorsheyd, Anouk; Scholman, W.L.G.; Kraaijenhagen, Rob J.; Akkerman, Jan-Willem Ν.; Wiel, A. van de

doi:10.1097/01.alc.0000141808.62230.75

Cited by 34 publications

(19 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With regard to the etiology, in addition to hyperfibrinolysis and a reduction in the number of platelets and coagulation factors (32), it is speculated that several factors related to alcohol are associated with the promotion of bleeding in ALD patients, including blood vessel wall fragility (14), inhibition of platelet adhesion in response to fibrinogen (36) and a dose-dependent reduction in platelet aggregation induced by extravasation (37). With regard to the latter phenomenon, except for the English and Japanese literature, only three case reports have been published, all of which involved alcoholic cirrhosis (38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Alcoholic Liver Disease Complicated by Deep Bleeding into the Muscles or Retroperitoneum: Report of Three Cases and a Review of the Literature

et al. 2014

View full text Add to dashboard Cite

We herein report three cases of alcoholic cirrhosis complicated by deep bleeding. In two of the three cases, intramuscular or retroperitoneal hematomas developed spontaneously. In contrast, in the remaining case, an intramuscular hematoma developed after trauma. In the former two patients, the intramuscular hematomas recurred at other sites during hospitalization. All three patients received conservative therapy, and one patient with a retroperitoneal hematoma underwent transcatheter arterial embolization. All of the patients eventually died of liver failure. The occurrence of severe alcoholic liver disease with deep bleeding has recently been reported with increasing frequency, and clinicians should bear this condition in mind as a life-threatening complication of alcoholic liver disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Alcoholic Liver Disease Complicated by Deep Bleeding into the Muscles or Retroperitoneum: Report of Three Cases and a Review of the Literature

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Results from a number of studies indicate that consumption of moderate amounts of ethanol decrease the risk of heart disease (Stewart 2002;Imhof & Koenig 2003;de Lange et al 2004). The beneficial effects of moderate ethanol consumption may result from ethanol's effect on inflammation.…”

Section: Introductionmentioning

confidence: 99%

An explanation for the paradoxical induction and suppression of an acute phase response by ethanol

Pruett

2006

Alcohol

View full text Add to dashboard Cite

Binge ethanol (EtOH) consumption suppresses inflammatory responses and resistance to infection, but paradoxically it is associated with increased levels of acute phase proteins (which are indicators of inflammation) and an increased risk of inflammation mediated pathologies such as cardiovascular disease and cirrhosis of the liver. The latter effect may be mediated by increased translocation of bacteria leading to activation of toll-like receptor 4 (TLR4). In this study, the dose-response and time course of the effects of EtOH alone or EtOH in conjunction with a TLR 4 agonist (LPS) were evaluated in mice. Ethanol alone at a dosage of 6 g/kg induced an acute phase response (as indicated by ELISA for serum amyloid A and serum amyloid P) that was maximal 24 hr after dosing. Lower dosages of EtOH did not have this effect but did suppressed the acute phase response to LPS and the production of IL-6 up to 3 hr after dosing. EtOH at 6 g/kg did not induce an acute phase response in C3H/HeJ (TLR4 mutant) mice, indicating that this response is mediated through TLR4. These results provide a resolution for the apparently paradoxical pro-and anti-inflammatory actions of EtOH with regard to acute phase responses.

show abstract

“…One study also described an increase in fibrinolytic activity after alcohol withdrawal in chronic alcoholics [13]. Another study found somewhat contrasting results indicating an increase in platelet aggregation after binge drinking [14].…”

Section: Introductionmentioning

confidence: 99%

Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry

Engström

Schött

Reinstrup

2006

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

Objective: The objective of the study was to study the effects of ethanol on the coagulation and the fibrinolysis in whole blood. Methods: Blood samples from healthy volunteers were analysed before and after in vitro addition of ethanol in order to achieve ethanol concentrations of 0‰, 1‰, 2‰ and 4‰ respectively (0, 22, 44 and 88 mmol/l). Coagulation and fibrinolysis were then assessed using rotational thromboelastometry. Results: We found that increasing ethanol levels increasingly impaired coagulation as evaluated with rotational thromboelastometry with a maximum prolongation of Clot Formation Time of 118% at an ethanol level of 4‰ (p<0.000001). We also found a very strong impairment of fibrinolysis already at an ethanol level of 1‰. Conclusions: This is the first study assessing the effects of ethanol on coagulation and fibrinolysis in a whole blood model. The impairment of coagulation is similar in nature to the impairment found in patients suffering from hypothermia. The impairment is at a level that may be of clinical importance, e.g. in patients suffering from trauma. The inhibition of fibrinolysis is obvious already at an ethanol level of 1‰ and it may be a contributing factor to the increased amount of coronary and cerebrovascular ischemic events after binge drinking.

show abstract

Rapid Intake of Alcohol (Binge Drinking) Inhibits Platelet Adhesion to Fibrinogen Under Flow

Cited by 34 publications

References 43 publications

Alcoholic Liver Disease Complicated by Deep Bleeding into the Muscles or Retroperitoneum: Report of Three Cases and a Review of the Literature

Alcoholic Liver Disease Complicated by Deep Bleeding into the Muscles or Retroperitoneum: Report of Three Cases and a Review of the Literature

An explanation for the paradoxical induction and suppression of an acute phase response by ethanol

Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry

Contact Info

Product

Resources

About