1976
DOI: 10.1093/bja/48.6.527
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Rapid Induction of Ether Anaesthesia and Controlled Maintenance by a Combination of Intravenous and Inhalation Administration Without the Risk of Explosion

Abstract: The induction and maintenance of anaesthesia with ether using a combined intravenous infusion and a constant low inspired concentration are discribed. Predictions from a mathematical model were checked against animal experiments. Anaesthesia occurred within 5 min. The mehtod obviates the need for explosive mixtures.

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Cited by 3 publications
(2 citation statements)
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“…Ether was the most commonly used anesthetic agent for more than a hundred years since it was first introduced in 1846 in spite of disadvantages (eg, explosion risk; slow onset and difficult induction; and stimulation of vomiting and secretions and laryngeal spasm). 23,24 Administration routes of ether for anesthesia during surgery occurred by inhalation, rectally, and IV. Extensive experience with IV administration of ether was gained by Burkhardt (Germany), Rood (UK), and Hohan (USA) in the early 20th century, highlighting smoother induction, less postoperative nausea, and avoidance of explosive mixtures.…”
Section: Metered Infusions and Syringe Drivers For Continuous Infusionmentioning
confidence: 99%
“…Ether was the most commonly used anesthetic agent for more than a hundred years since it was first introduced in 1846 in spite of disadvantages (eg, explosion risk; slow onset and difficult induction; and stimulation of vomiting and secretions and laryngeal spasm). 23,24 Administration routes of ether for anesthesia during surgery occurred by inhalation, rectally, and IV. Extensive experience with IV administration of ether was gained by Burkhardt (Germany), Rood (UK), and Hohan (USA) in the early 20th century, highlighting smoother induction, less postoperative nausea, and avoidance of explosive mixtures.…”
Section: Metered Infusions and Syringe Drivers For Continuous Infusionmentioning
confidence: 99%
“…In den 20er Jahren wurde die intravenöse Ethernarkose häufiger angewandt (23,24,25). Von 1930 bis 1950 wird sie sporadisch envahnt, wobei eine positive Einschätzung dieser Methode besteht (26,27,28 1 0 Etherlösung gibt Zwart mit 500 bis 600 ml für einen erwachsenen Mann an (36). W. Spiess benutzte 1979 eine 5°/~Etherlösung zur intravenösen Anästhesie mit geschlossenem System und beurteilte die Methode als sicher und effektiv (37).…”
Section: Das Weitere Schicksal Der Intravenösen Ethernarkoseunclassified