Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation

Inagaki, Hiroko; Saito, Akatsuki; Sugiyama, Hironobu; Okabayashi, Tamaki; Fujimoto, Shouichi

doi:10.1080/22221751.2020.1796529

Cited by 261 publications

(238 citation statements)

References 14 publications

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“…Canine coronaviruses (13). Hence, as recently demonstrated by others (8)(9)(10) and now confirmed by our study it was expected that SARS-CoV-2 is permissive for inactivation by UV-C treatment. One critical question is the suitability of this technology in a "real-life" setting in which the exposure time of surfaces or aerosols should be kept as short as possible to allow for a realistic application, for example in rooms that need to be used frequently as operating rooms or lecture halls.…”

Section: Discussionsupporting

confidence: 90%

“…This is substantially less than the previously reported 1048 mJ/cm² necessary to achieve a 6-log reduction in virus titers when exposing aqueous SARS-CoV-2 to UV-C (10). In another study, using a 222 nm UV-LED source, 3 mJ/cm² lead to a 4-log reduction of infectious SARS-CoV-2 (9) and 20 s deep-ultraviolet treatment at 280 nm corresponding to a dose of 75 mJ/cm² reduced 3-logs (8).…”

Section: Discussionmentioning

confidence: 97%

“…This procedure has proven effective to inactivate SARS-CoV-1 (4)(5)(6), several other enveloped and non-enveloped viruses as well as bacteria (7). Recently, it has also been shown that SARS-CoV-2 is sensitive to inactivation by UV-C irradiation (8)(9)(10). However, doses and exposure times necessary for total inactivation of SARS-CoV-2 were in a range precluding efficient application of UV-based methods to be employed for large-scale decontamination of surfaces and aerosols (10).…”

Section: Introductionmentioning

confidence: 99%

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Rapid, dose-dependent and efficient inactivation of surface dried SARS-CoV-2 by 254 nm UV-C irradiation

Ruétalo

Businger

Schindler

2020

Preprint

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The SARS-CoV-2 pandemic urges for cheap, reliable and rapid technologies for disinfection and decontamination. We here evaluated the efficiency of UV-C irradiation to inactivate surface dried SARS-CoV-2. Drying for two hours did not have a major impact on the infectivity of SARS-CoV-2, indicating that exhaled virus in droplets or aerosols stays infectious on surfaces at least for a certain amount of time. Strikingly, short exposure of high titer surface dried virus (3*10^6 IU/ml) with UV-C light (0.66 mJ/cm^2) resulted in a total reduction of SARS-CoV-2 infectivity. Together, our results demonstrate that SARS-CoV-2 is rapidly inactivated by relatively low doses of UV-C irradiation. Hence, UV-C treatment is an effective non-chemical possibility to decontaminate surfaces from high-titer infectious SARS-CoV-2.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Rapid, dose-dependent and efficient inactivation of surface dried SARS-CoV-2 by 254 nm UV-C irradiation

Ruétalo

Businger

Schindler

2020

Preprint

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“…The important role of clear guidance from government is further exemplified from the suggestion during US government briefings that consideration should be given to the internal use of disinfectant and UV light in combating COVID-19. This is a clear example of misinformation arising from misinterpreted scientific literature that led to widescale panic and increased calls to poison centers [ 59 - 61 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Prevalence of Reactive Online Searching in the COVID-19 Pandemic: Infoveillance Study

Badell-Grau¹,

Cuff²,

Kelly³

et al. 2020

J Med Internet Res

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Background The ongoing pandemic has placed an unprecedented strain on global society, health care, governments, and mass media. Public dissemination of government policies, medical interventions, and misinformation has been remarkably rapid and largely unregulated during the COVID-19 pandemic, resulting in increased misinterpretations, miscommunication, and public panic. Being the first full-scale global pandemic of the digital age, COVID-19 has presented novel challenges pertinent to government advice, the spread of news and misinformation, and the trade-off between the accessibility of science and the premature public use of unproven medical interventions. Objective This study aims to assess the use of internet search terms relating to COVID-19 information and misinformation during the global pandemic, identify which were most used in six affected countries, investigate any temporal trends and the likely propagators of key search terms, and determine any correlation between the per capita cases and deaths with the adoption of these search terms in each of the six countries. Methods This study uses relative search volume data extracted from Google Trends for search terms linked to the COVID-19 pandemic alongside per capita case and mortality data extracted from the European Open Data Portal to identify the temporal dynamics of the spread of news and misinformation during the global pandemic in six affected countries (Australia, Germany, Italy, Spain, the United Kingdom, and the United States). A correlation analysis was carried out to ascertain any correlation between the temporal trends of search term use and the rise of per capita mortality and disease cases. Results Of the selected search terms, most were searched immediately following promotion by governments, public figures, or viral circulation of information, but also in relation to the publication of scientific resources, which were sometimes misinterpreted before further dissemination. Strong correlations were identified between the volume of these COVID-19–related search terms (overall mean Spearman rho 0.753, SD 0.158), and per capita mortality (mean per capita deaths Spearman rho 0.690, SD 0.168) and cases (mean per capita cases Spearman rho 0.800, SD 0.112). Conclusions These findings illustrate the increased rate and volume of the public consumption of novel information during a global health care crisis. The positive correlation between mortality and online searching, particularly in countries with lower COVID-19 testing rates, may demonstrate the imperative to safeguard official communications and dispel misinformation in these countries. Online news, government briefings, and social media provide a powerful tool for the dissemination of important information to the public during pandemics, but their misuse and the presentation of misrepresented medical information should be monitored, minimized, and addressed to safeguard public safety. Ultimately, governments, public health authorities, and scientists have a moral imperative to safeguard the truth and maintain an accessible discourse with the public to limit fear.

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“…Recent works performed using UVC on SARS-CoV-2 showed various doses. The work of Hiroko Inagaki [7] proposes a dose of 37 mJ/cm 2 using UVC of 280 nm. The work of Andrea Bianco [8] proposes a dose of 6.7 mJ/cm 2 using a source of 254 nm.…”

Section: Introductionmentioning

confidence: 99%

Beware of UVC sanitizers: not all are good

Arines

Bao-Varela

2020

Preprint

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Disinfection is now one of the major concerns of society. Soap, or hydroalcohol are two known ways of sanitizing different objects. Now we can find in the market more sophisticated systems, which provide more confidence on their sanitizing effects, or that allows disinfection of objects that cannot be sanitized with soap or hydroalcoholic solutions. In this work we analyze a commercially available sanitizing device that claims the use of UVC radiation. We will show that this device is not suitable for complete disinfection of the objects introduced on the cabin. We provide spectral characterization of the sources, as well as irradiance measurements inside the cabin. We conclude that the cabin cannot be used for sanitizing most of the objects that are included in the documentation of the device.

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Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation

Cited by 261 publications

References 14 publications

Rapid, dose-dependent and efficient inactivation of surface dried SARS-CoV-2 by 254 nm UV-C irradiation

Rapid, dose-dependent and efficient inactivation of surface dried SARS-CoV-2 by 254 nm UV-C irradiation

Investigating the Prevalence of Reactive Online Searching in the COVID-19 Pandemic: Infoveillance Study

Beware of UVC sanitizers: not all are good

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